CS-1775
4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
CAS: 607737-87-1
Molecular Formula: C18H14N4
CS-1775 - Names and Identifiers
| Name | 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE |
| Synonyms | A77-01 A-77-01 CS-1775 A 77-01 4-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE 4-[5-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]quinoline 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline A 77-01 |
| CAS | 607737-87-1 |
CS-1775 - Physico-chemical Properties
| Molecular Formula | C18H14N4 |
| Molar Mass | 286.33 |
| Storage Condition | 2-8℃ |
CS-1775 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.492 ml | 17.462 ml | 34.925 ml |
| 5 mM | 0.698 ml | 3.492 ml | 6.985 ml |
| 10 mM | 0.349 ml | 1.746 ml | 3.492 ml |
| 5 mM | 0.07 ml | 0.349 ml | 0.698 ml |
Last Update：2024-01-02 23:10:35
CS-1775 - Reference Information
| biological activity | A 77-01 is A potent inhibitor of the TGF-β Type I receptor family ALK5 with an IC50 value of 25 nM. |
| Target | IC50: 25 nM (ALK5) |
| Cell Line: | Mv1Lu cells Mv1Lu cells HaCaT cells |
| Concentration: | 0.01 µM, 0.03 µM, 0.1 µM, 0.3 µM, 1 µM, 3 µM, 10 µM 1 µM 1 µM |
| Incubation Time: | 25 hours 24 hours, 48 hours, 72 hours 30 minutes |
| Result: | Inhibited the luciferase activity induced by TGF-β in concentration-dependent fashion. Efficiently prevented the growth-inhibitory effects of TGF-β. Inhibited TGF-β-induced phosphorylation of Smad2. |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE Visit Supplier Webpage Request for quotationCAS: 607737-87-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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