CS-2038

Name	CC-115
Synonyms	CC115 CC 115 CC-115 CS-2038 CC-115(free base) 1-Ethyl-7-(2-methyl-6-(4h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one Pyrazino[2,3-b]pyrazin-2(1H)-one, 1-ethyl-3,4-dihydro-7-[2-methyl-6-(1H-1,2,4-triazol-5-yl)-3-pyridinyl]-
CAS	1228013-15-7

Molecular Formula	C16H16N8O
Molar Mass	336.35
Density	1.56±0.1 g/cm3(Predicted)
Boling Point	587.3±60.0 °C(Predicted)
Solubility	DMSO: ≥ 32 mg/mL
pKa	5.94±0.20(Predicted)
Storage Condition	-20℃
In vitro study	CC-115 inhibits the DNA damage repair pathway and TORK in CLL cells and causes caspase-induced cell death in dormant CLL cells. It induced cell death with an IC50 of 0.51 μm. CC-115 was able to restore cd40-induced chemoresistance, reducing the expression of Mcl-1, Bfl-1 and Bcl-XL induced by cd40-stimulation in CLL cells. It also inhibits the proliferation of CLL cells. In healthy B cells, CC-115 induced cell death with an IC50 of 0.93 μm. CC-115 and NU7441 can completely block the proliferation of CD4 and CD8 T cells. Overall, CC-115 can induce direct toxicity, inhibiting signaling pathways important for CLL survival, chemoresistance, and proliferation.
In vivo study	In patients with chronic lymphocytic leukemia (CLL patients), CC-115 reduce their lymphadenopathy. In a variety of species, CC-115 has a good in vivo pharmacokinetic distribution, the oral bioavailability in mice, rats, dogs were 53%, 76%, ~ 100%. CC-115 has favorable physicochemical and pharmacokinetic properties, inhibits the mTOR signaling pathway and inhibits tumor growth in vivo. In vitro and in vivo experiments have drug safety, suitable for clinical drug development.

Last Update：2024-01-02 23:10:35

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Product Name: CC-115 Visit Supplier Webpage Request for quotation
CAS: 1228013-15-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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CS-2038

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