CS-253
PF-573228
CAS: 869288-64-2
Molecular Formula: C22H20F3N5O3S
CS-253 - Names and Identifiers
CS-253 - Physico-chemical Properties
| Molecular Formula | C22H20F3N5O3S |
| Molar Mass | 491.49 |
| Density | 1.459 |
| Melting Point | >242°C (dec.) |
| Solubility | DMSO: ≥20mg/mL |
| Appearance | powder |
| Color | white to off-white |
| pKa | 14.30±0.20(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD11519967 |
| Use | PF-573228 |
| In vitro study | PF 573228 inhibits FAK Tyr in REF52 cells, PC3 cells, SKOV-3 cells, and L3.6p1 and F-G, MDCK Cells |
| In vivo study | In Ctrl-MT mice, PF-573228 inhibition of FAK can significantly inhibit the occurrence of breast tumor and metastasis of lung cancer. In contrast, treatment of PF-573228 mice with MFCKO-MT did not affect the development of breast tumors, which may be related to the lack of FAK in mammary epithelial cells in these mice. |
CS-253 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36 - Irritating to the eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
CS-253 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.035 ml | 10.173 ml | 20.346 ml |
| 5 mM | 0.407 ml | 2.035 ml | 4.069 ml |
| 10 mM | 0.203 ml | 1.017 ml | 2.035 ml |
| 5 mM | 0.041 ml | 0.203 ml | 0.407 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: PF-573228 Visit Supplier Webpage Request for quotationCAS: 869288-64-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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