CS-2595
STF 083010
CAS: 307543-71-1
Molecular Formula: C15H11NO3S2
CS-2595 - Names and Identifiers
CS-2595 - Physico-chemical Properties
| Molecular Formula | C15H11NO3S2 |
| Molar Mass | 317.38 |
| Density | 1.40±0.1 g/cm3(Predicted) |
| Melting Point | 199-201°C |
| Boling Point | 548.4±56.0 °C(Predicted) |
| Solubility | DMSO: 31.7 mg/mL (100 mM)( < 1 mg/ml refers to the product slightly soluble or insoluble) |
| Appearance | powder |
| Color | light yellow to yellow-green |
| pKa | 7.31±0.50(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
| Use | STF-083010 is a specific inhibitor of IRE1α. After endoplasmic reticulum stress, STF-083010 inhibited Ire1 endonuclease activity without affecting its kinase activity. |
| Target | IRE1 |
| In vitro study | STF-083010 shows cytostatic and cytotoxic activity in a dose- and time-dependent manner. Treatment with STF-083010 shows significant antimyeloma activity in model human multiple myeloma (MM) xenografts. RPMI 8226 human MM cells grown as tumor xenografts are treated in NSG mice. Intraperitoneal injection of STF-083010 alone (day 1, day 8) significantly inhibits the growth of these tumors. STF-083010 is an IRE1α-specific inhibitor. Four pancreatic cancer cell lines (Panc0403, Panc1005, BxPc3, MiaPaCa2) are treated with different combination of Bortezomib (10 or 50 nM) and STF (10 or 50 μM). The normalized isobologram analysis demonstrates synergistic activity between 10 μM STF and either 10 or 50 nM bortezomib in all four cell lines. Moreover, a higher concentration of STF (50 μM) attains synergy after addition of bortezomib either at a concentration of 10 nM when tested against BxPc3 cells, at a concentration of 50 nM against Panc1005 cells, and at either 10 or 50 nM against Panc0403 cells. STF-083010 (50 μM) suppresses the growth of p53-deficient human cancer cells. |
| In vivo study | Treatment with STF-083010 reduces the viability of HCT116 p53 -/- cells by approximately 20% compared with that of HCT116 p53 -/- cells. Administration of STF-083010 to tumors induced by HCT116 p53 -/- cells significantly reduces tumor volume and weight by 75% and 73% at the endpoint, respectively. |
CS-2595 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
CS-2595 - Reference
| Reference Show more | 1: Tang ZH, Su MX, Guo X, Jiang XM, Jia L, Chen X, Lu JJ. Increased expression of IRE1α associates with the resistant mechanism of osimertinib (AZD9291)-resistant non-small cell lung cancer HCC827/OSIR cells. Anticancer Agents Med Chem. 2017 Jul 19. doi: 10.2174/1871520617666170719155517. [Epub ahead of print] PubMed PMID: 28730963. 2: Liu Y, Jiang ZY, Zhou YL, Qiu HH, Wang G, Luo Y, Liu JB, Liu XW, Bu WQ, Song J, Cui L, Jia XB, Feng L. β-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells through PERK/IRE1α/ATF6 pathway. Biomed Pharmacother. 2017 Sep;93:490-497. doi: 10.1016/j.biopha.2017.06.073. Epub 2017 Jun 30. PubMed PMID: 28672279. 3: Song YF, Hogstrand C, Wei CC, Wu K, Pan YX, Luo Z. Endoplasmic reticulum (ER) stress and cAMP/PKA pathway mediated Zn-induced hepatic lipolysis. Environ Pollut. 2017 Sep;228:256-264. doi: 10.1016/j.envpol.2017.05.046. Epub 2017 May 23. PubMed PMID: 28549333. 4: Wang X, Xu M, Frank JA, Ke ZJ, Luo J. Thiamine deficiency induces endoplasmic reticulum stress and oxidative stress in human neurons derived from induced pluripotent stem cells. Toxicol Appl Pharmacol. 2017 Apr 1;320:26-31. doi: 10.1016/j.taap.2017.02.009. Epub 2017 Feb 11. PubMed PMID: 28193519. |
CS-2595 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.151 ml | 15.754 ml | 31.508 ml |
| 5 mM | 0.63 ml | 3.151 ml | 6.302 ml |
| 10 mM | 0.315 ml | 1.575 ml | 3.151 ml |
| 5 mM | 0.063 ml | 0.315 ml | 0.63 ml |
Last Update：2024-01-02 23:10:35
CS-2595 - Introduction
STF 083010 is a chemical substance whose chemical name is 2,4, 6-trifluorophenyltris (2,2, 2-trifluoroethyl) amine. The following is an introduction to the nature, use, formulation and safety information of STF 083010:
Nature:
-Appearance: White or off-white solid
-Solubility: Dissolved in some organic solvents, such as dichloromethane, dimethyl sulfoxide, etc.
-Melting point: About 100-105 degrees Celsius
-Stability: STF 083010 is relatively stable under regular conditions, but may decompose when exposed to strong oxidants or strong acids
Use:
- STF 083010 catalysts commonly used in organic synthesis reactions
-It has excellent catalytic activity and selectivity, and is widely used in the field of organic synthesis such as catalytic hydrogenation reaction and hydroquinone reduction reaction
-Due to its good catalytic performance, STF 083010 is widely used in the pharmaceutical field and the production of agricultural chemicals
Preparation Method:
- STF 083010 has many preparation methods. The common method is to combine related compounds (such as aniline) with fluoroethyl compounds (such as trifluoroethyl sodium fluoride) under specific conditions reactions are obtained.
Safety Information:
- STF 083010 may be irritating to the skin, eyes and mucous membranes, so care should be taken to use personal protective equipment, such as gloves, goggles, etc., when exposed to this substance
-avoid breathing gas, dust or solution when handling STF 083010
-When using the substance, it must be operated in a well-ventilated place
-When storing STF 083010, keep it in a dry, sealed container, away from fire and oxidizing agents
-If STF 083010 is swallowed or inhaled, please consult your doctor promptly and provide the packaging or label to your doctor for reference
Nature:
-Appearance: White or off-white solid
-Solubility: Dissolved in some organic solvents, such as dichloromethane, dimethyl sulfoxide, etc.
-Melting point: About 100-105 degrees Celsius
-Stability: STF 083010 is relatively stable under regular conditions, but may decompose when exposed to strong oxidants or strong acids
Use:
- STF 083010 catalysts commonly used in organic synthesis reactions
-It has excellent catalytic activity and selectivity, and is widely used in the field of organic synthesis such as catalytic hydrogenation reaction and hydroquinone reduction reaction
-Due to its good catalytic performance, STF 083010 is widely used in the pharmaceutical field and the production of agricultural chemicals
Preparation Method:
- STF 083010 has many preparation methods. The common method is to combine related compounds (such as aniline) with fluoroethyl compounds (such as trifluoroethyl sodium fluoride) under specific conditions reactions are obtained.
Safety Information:
- STF 083010 may be irritating to the skin, eyes and mucous membranes, so care should be taken to use personal protective equipment, such as gloves, goggles, etc., when exposed to this substance
-avoid breathing gas, dust or solution when handling STF 083010
-When using the substance, it must be operated in a well-ventilated place
-When storing STF 083010, keep it in a dry, sealed container, away from fire and oxidizing agents
-If STF 083010 is swallowed or inhaled, please consult your doctor promptly and provide the packaging or label to your doctor for reference
Last Update：2024-04-09 20:49:11
Supplier List
Spot supply
Product Name: STF 083010 Visit Supplier Webpage Request for quotationCAS: 307543-71-1
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Spot supply
Product Name: STF 083010 Visit Supplier Webpage Request for quotationCAS: 307543-71-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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