CS-2680

Name	Nosiheptide
Synonyms	101159 CS-2680 priMofax Nosiheptide Multhiomycin Nosiheptide VETRANAL Nosiheptide (Multhiomycin)
CAS	56377-79-8
EINECS	260-138-4
InChI	InChI=1/C51H43N13O12S6/c1-5-23-46-60-28(14-79-46)41(70)56-25-10-33(67)50(74)76-11-21-7-6-8-24-34(21)18(2)35(54-24)51(75)82-17-31(57-42(71)29-15-80-47(25)61-29)48-58-26(12-78-48)37-22(45-59-30(13-77-45)43(72)64-36(20(4)65)44(73)55-23)9-32(66)38(63-37)49-62-27(16-81-49)40(69)53-19(3)39(52)68/h5-9,12-16,20,25,31,33,36,54,65-67H,3,10-11,17H2,1-2,4H3,(H2,52,68)(H,53,69)(H,55,73)(H,56,70)(H,57,71)(H,64,72)/b23-5-

Molecular Formula	C51H43N13O12S6
Molar Mass	1222.34
Density	1.534±0.06 g/cm3(Predicted)
Melting Point	310-320° (dec)
Specific Rotation(α)	D20 +38° (c = 1 in pyridine)
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	Light Yellow to Light Brown
pKa	1.42±0.60(Predicted)
Storage Condition	Sealed in dry,Store in freezer, under -20°C
Refractive Index	1.698
In vitro study	Nosiheptide exhibits extremely potent activity against all contemporary Staphylococcus aureus strains tested including multiple drug-resistant clinical isolates, with MIC values ≤ 0.25 mg/L. Nosiheptide is also highly active against Enterococcus spp and the contemporary hypervirulent BI strain of Clostridium difficile but is inactive against most Gram-negative strains tested. Time-kill analysis reveals Nosiheptide to be rapidly bactericidal against Staphylococcus aureus in a concentration- and time-dependent manner, with a nearly 2-log kill noted at 6 hours at 10X MIC. Furthermore, Nosiheptide is found to be non-cytotoxic against mammalian cells at >> 100X MIC, and its anti- Staphylococcus aureus activity is not inhibited by 20% human serum. Notably, Nosiheptide exhibits a significantly prolonged post-antibiotic effect against both healthcare- and community-associated Staphylococcus aureus compared to vancomycin.

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Product Name: Nosiheptide Request for quotation
CAS: 56377-79-8
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Product Name: Nosiheptide Visit Supplier Webpage Request for quotation
CAS: 56377-79-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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CS-2680

CS-2680 Request for Quotation