Name | TP-3654 |
Synonyms | TP3654 TP3654 CS-2702 TP 3654 TP-3654 Cyclohexanemethanol, α,α-dimethyl-4-[[3-[3-(trifluoromethyl)phenyl]imidazo[1,2-b]pyridazin-6-yl]amino]-, trans- |
CAS | 1361951-15-6 |
Molecular Formula | C22H25F3N4O |
Molar Mass | 418.46 |
Solubility | DMSO: 10 mM |
Storage Condition | -20℃ |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.39 ml | 11.949 ml | 23.897 ml |
5 mM | 0.478 ml | 2.39 ml | 4.779 ml |
10 mM | 0.239 ml | 1.195 ml | 2.39 ml |
5 mM | 0.048 ml | 0.239 ml | 0.478 ml |
biological activity | TP-3654 is the second generation PIM inhibitor, and the Ki values for PIM-1, PIM-2 and PIM-3 are 5 nM, 239 nM and 42 nM respectively. |
target | TargetValue pim1 (cell-free say) 5 nm (ki) pim3 (cell-free say) 42 nm (ki) pim2 (cell-free say) 239 nm (ki) |
Target | Value |
Pim1 (Cell-free assay) | 5 nM(Ki) |
Pim3 (Cell-free assay) | 42 nM(Ki) |
Pim2 (Cell-free assay) | 239 nM(Ki) |