CS-860
SB 3CT
CAS: 292605-14-2
Molecular Formula: C15H14O3S2
CS-860 - Names and Identifiers
| Name | SB 3CT |
| Synonyms | SB 3CT CS-860 SB-3CT [[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane 2-[[(4-phenoxyphenyl)sulfonyl]methyl]-thiirane SB-3CT (This product is only available in Japan.) |
| CAS | 292605-14-2 |
CS-860 - Physico-chemical Properties
| Molecular Formula | C15H14O3S2 |
| Molar Mass | 306.4 |
| Melting Point | 92-96°C |
| Solubility | DMSO: 30.6 mg/mL (100 mM)Ethanol: 6.1 mg/mL (20 mM)( < 1 mg/ml refers to the product slightly soluble or insoluble) |
| Appearance | powder |
| Color | white to off-white |
| Storage Condition | -20°C |
| Use | SB-3CT is an effective competitive metalloproteinase MMP-2 and MMP-9 inhibitor with Ki values of 13.9 nM and 600 nM respectively. SB-3CT has high selectivity to gelatinase. SB-3CT can penetrate the blood-brain barrier and have neuroprotective and anti-cancer effects. |
| Target | MMP-2; MMP-9 |
| In vitro study | SB-3CT direct inhibition of bone marrow endothelial cell infiltration and tubule formation in vitro. SB-3CT inhibited bone marrow endothelial cell infiltration and tubule formation directly in the artificial basement membrane in vitro. |
| In vivo study | In the L-CI.5sT-cell lymphatic model, SB-3CT (5-50 mg/kg/day, I. P.) effectively inhibited the metastasis of liver cancer cells and improved the survival rate of mice. SB-3CT (50 mg/kg/day, I. P.) inhibited human prostate cancer cell growth, osteolysis, and angiogenesis in a bone metastasis model. In a mouse model of "permanent" cerebral ischemia caused by emboli, SB-3CT blocked the degeneration of neuronal laminin, protecting neurons from ischemic cell death, and improve the outcome of neurological behavior after embolic MCA occlusion. In a L-CI.5sT-cell lymphoid model, SB-3CT (5-50 mg/kg/day, I. P.) effectively inhibited liver cancer cell metastasis and increased survival in mice. SB-3CT (50 mg/kg/day, I. P.) inhibited human prostate cancer cell growth, osteolysis, and angiogenesis in a bone metastasis model. In a mouse model of "permanent" cerebral ischemia caused by emboli, SB-3CT blocked the degeneration of neuronal laminin, protecting neurons from ischemic cell death, and improve the outcome of neurological behavior after embolic MCA occlusion. |
CS-860 - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| HS Code | 29349990 |
CS-860 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.264 ml | 16.319 ml | 32.637 ml |
| 5 mM | 0.653 ml | 3.264 ml | 6.527 ml |
| 10 mM | 0.326 ml | 1.632 ml | 3.264 ml |
| 5 mM | 0.065 ml | 0.326 ml | 0.653 ml |
Last Update：2024-01-02 23:10:35
CS-860 - Cell Experiment
SB-3CT is dissolved in DMSO (10 mM) and stored (-22°C), and then diluted with appropriate media (DMSO 1%) before use[2]. PC3 cells are seeded in 35-mm dishes (5×104 cells/dish) in complete culture medium. The next day, the medium is replaced with complete medium supplemented with 1% DMSO alone (vehicle) or SB-3CT (final concentrations 0.1-50 μM) in 1% DMSO. At various times, the cells are harvested with trypsin and counted。
Last Update：2023-08-16 21:32:38
CS-860 - Reference Information
| biological activity | SB-3CT is a highly potent and selective gelatinase inhibitor, its Ki for MMP-2 and MMP-9 was 13.9 nM and 600 nM, respectively. SB-3CT is a highly selective gelatinase inhibitor with a Ki of 13.9 nM and 600 nM for MMP-2 and MMP-9, respectively. |
| in vitro study | SB-3CT directly inhibits bone marrow endothelial cell infiltration and tubule formation in an in vitro artificial basement membrane. SB-3CT inhibited bone marrow endothelial cell infiltration and tubule formation directly in the artificial basement membrane in vitro. |
| in vivo study | L-CI.5sT (5-50 mg/kg/day, I. P.) in a SB-3CT-cell lymphoid model effectively inhibit the metastasis of liver cancer cells and improve the survival rate of mice. SB-3CT (50 mg/kg/day, I. P.) inhibited human prostate cancer cell growth, osteolysis, and angiogenesis in a bone metastasis model. In a mouse model of "permanent" cerebral ischemia caused by emboli, SB-3CT blocked the degeneration of neuronal laminin, protecting neurons from ischemic cell death, and improve the outcome of neurological behavior after embolic MCA occlusion. In a L-CI.5sT-cell lymphoid model, SB-3CT (5-50 mg/kg/day, I. P.) effectively inhibited liver cancer cell metastasis and increased survival in mice. SB-3CT (50 mg/kg/day, I. P.) inhibited human prostate cancer cell growth, osteolysis, and angiogenesis in a bone metastasis model. In a mouse model of "permanent" cerebral ischemia caused by emboli, SB-3CT blocked the degeneration of neuronal laminin, protecting neurons from ischemic cell death, and improve the outcome of neurological behavior after embolic MCA occlusion. |
| Target | TargetValue MMP-2 (Cell-free assay) 13.9 nM(Ki) MMP-9 (Cell-free assay) 600 nM(Ki) |
| Target | Value |
| MMP-2 (Cell-free assay) | 13.9 nM(Ki) |
| MMP-9 (Cell-free assay) | 600 nM(Ki) |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: SB 3CT Visit Supplier Webpage Request for quotationCAS: 292605-14-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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