CS-902
QNZ (EVP4593)
CAS: 545380-34-5
Molecular Formula: C22H20N4O
CS-902 - Names and Identifiers
| Name | QNZ (EVP4593) |
| Synonyms | QNZ CS-902 EVP4593 EVP-4593 EVP 4593 EVP 4593 EVP-4593 QNZ (EVP4593) 4,6-Quinazolinediamine, N4-[2-(4-phenoxyphenyl)ethyl]- |
| CAS | 545380-34-5 |
CS-902 - Physico-chemical Properties
| Molecular Formula | C22H20N4O |
| Molar Mass | 356.42 |
| Melting Point | 169-175°C |
| Solubility | DMSO: soluble15mg/mL, clear |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| MDL | MFCD06411436 |
| Use | QNZ (EVP4593) effectively inhibited NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively. |
| In vitro study | EVP4593 inhibited LPS-stimulated TNF-α production in mouse splenocytes with an IC 50 of 7 nM. In Htt138Q cells, 1 μm of tharotene induced EVP4593(300 nM) significantly reduced the current of the storage operation (about 60%), thereby preventing abnormal Library-operated calcium flux. EVP4593 was able to inhibit the activity of one of the channels containing TRPC1 subunits, but had no effect on the specialized constituent Homo-oligomeric channels of trpc1. QNZ(40 nM) completely inhibited the elevation of axon number and length induced by laminin treatment of Schwann cells. QNZ reduced the protrusion length of Schwann cells by 61.36. QNZ significantly inhibited laminin-induced axon growth. QNZ also greatly weakened axonal extension in 72-hour culture, implying that initial budding and long-term growth and extension seen in response to Schwann cell inoculation on laminin were mediated by NF-κB. QNZ(10 nM) inhibits LPS-induced upregulation of CSE expression in rat neutrophils. QNZ (100 nM) inhibited the induction of GRO/ KC on K-current in ib4-negative neurons. |
| In vivo study | In rats, EVP4593 (1 mg/kg, I. p.) dose-dependently inhibited the effect of carrageenan-induced paw swelling. |
CS-902 - Risk and Safety
| WGK Germany | 3 |
CS-902 - Reference
| Reference Show more | 1. Zhang, Zhi Hong, et al. "Chelidonine inhibits TNF‐α‐induced inflammation by suppressing the NF‐κB pathways in HCT116 cells." Phytotherapy Research 32.1 (2018): 65-75.https://doi.org/10.1002/ptr.5948 |
CS-902 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.806 ml | 14.028 ml | 28.057 ml |
| 5 mM | 0.561 ml | 2.806 ml | 5.611 ml |
| 10 mM | 0.281 ml | 1.403 ml | 2.806 ml |
| 5 mM | 0.056 ml | 0.281 ml | 0.561 ml |
Last Update：2024-01-02 23:10:35
CS-902 - Reference Information
| biological activity | QNZ (EVP4593) effectively inhibited NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively. |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: QNZ (EVP4593) Visit Supplier Webpage Request for quotationCAS: 545380-34-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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