CS-977
EMD 1214063
CAS: 1100598-32-0
Molecular Formula: C29H28N6O2
CS-977 - Names and Identifiers
CS-977 - Physico-chemical Properties
| Molecular Formula | C29H28N6O2 |
| Molar Mass | 492.57 |
| Density | 1.25 |
| Boling Point | 626.5±65.0 °C(Predicted) |
| pKa | 8.93±0.10(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | EMD 1214063 inhibited HGF-induced phosphorylation in A549 cells by c-Met with an IC50 of 6 nM. EMD 1214063 treatment induced a significant reduction in phosphorylation of EBC-1 components in c-Met cells with an IC50 of 9 nM. EMD 1214063 effectively blocks the phosphorylation of major downstream effector proteins of c-Met enzymes, such as Grb2,Gab1,Sos,PLC gamma, and phosphatidylinositol 3-kinase, in EBC-1,MKN-45, and Hs746T cells, range from 1 to 10 nM. EMD 1214063 greatly inhibited the activity of MKN-45 cells, IC50 less than 1 nM. Treatment with EMD 1214063 (0.1 nM) inhibited HGF-induced NCI-H441 cell migration, whereas concentrations from 100 nM to 1 μm inhibited it almost completely. EMD 1214063 inhibited HGF-induced phosphorylation in A549 cells by c-Met with IC50 of 6 nM. EMD 1214063 treatment induced a significant reduction in phosphorylation of EBC-1 components in c-Met cells with an IC50 of 9 nM. EMD 1214063 effectively blocks the phosphorylation of major downstream effector proteins of c-Met enzymes, such as Grb2,Gab1,Sos,PLC gamma, and phosphatidylinositol 3-kinase, in EBC-1,MKN-45, and Hs746T cells, range from 1 to 10 nM. EMD 1214063 greatly inhibited the activity of MKN-45 cells, IC50 less than 1 nM. Treatment with EMD 1214063 (0.1 nM) inhibited HGF-induced NCI-H441 cell migration, whereas concentrations from 100 nM to 1 μm inhibited it almost completely. |
| In vivo study | Treatment of EMD 1214063 at a dose of 10 mg/kg or higher resulted in inhibition of c-Met phosphorylation in more than 90% of Hs746T xenograft tumors for at least 72 hours. EMD 1214063 induced a greater than 50% reduction in the expression of cyclin D1 and this effect persisted for more than 96 hours at a dose of 100 mg/kg. Transient p27 sensing and cleavage of caspase-3 was also observed after EMD 1214063 treatment. EMD 1214063 (15 mg/kg per day) treatment induced c-Met amplification, overexpression, and complete regression of gastric cancer xenograft Hs746T activated in a ligand-independent manner. EMD 1214063 treatment at a dose of 10 mg/kg or higher resulted in inhibition of c-Met phosphorylation in more than 90% of Hs746T xenograft tumors for at least 72 hours. EMD 1214063 induced a greater than 50% reduction in the expression of cyclin D1 and this effect persisted for more than 96 hours at a dose of 100 mg/kg. Transient p27 sensing and cleavage of caspase-3 was also observed after EMD 1214063 treatment. EMD 1214063 (15 mg/kg per day) treatment induced c-Met amplification, overexpression, and complete regression of gastric cancer xenograft Hs746T activated in a ligand-independent manner. |
CS-977 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.03 ml | 10.151 ml | 20.302 ml |
| 5 mM | 0.406 ml | 2.03 ml | 4.06 ml |
| 10 mM | 0.203 ml | 1.015 ml | 2.03 ml |
| 5 mM | 0.041 ml | 0.203 ml | 0.406 ml |
Last Update：2024-01-02 23:10:35
CS-977 - Introduction
EMD 1214063 is an organic compound with the chemical name N-(2 ',6'-dimethylbenzyl)-N-(4-(4-methyl-2-thiazolyl) phenyl) formamide. It is a white solid.
EMD 1214063 is a compound with potential pharmaceutical activity and is used as a new compound of mitomycin antibiotics. It has been reported to have antibacterial activity and inhibit the growth of some resistant bacteria.
in terms of preparation method, the synthesis method of EMD 1214063 is to synthesize the corresponding enolone compound first, and generate the amine compound by adding dehydrating agent and reacting.
Regarding safety information, the toxicity data 1214063 by EMD is relatively small, so the specific toxicity level and safety measures need to be further studied and determined. However, in any chemical laboratory, when using or handling the compound, you should follow appropriate laboratory safety procedures and wear appropriate personal protective equipment, such as laboratory gloves and protective glasses. In addition, the storage and disposal of compounds should also comply with relevant regulations and regulations. Drug substances should be properly kept to avoid misuse or leakage. For detailed information and recommendations for use of the substance, it is recommended to consult the safety data sheet provided by the chemical supplier or contact the relevant professional.
EMD 1214063 is a compound with potential pharmaceutical activity and is used as a new compound of mitomycin antibiotics. It has been reported to have antibacterial activity and inhibit the growth of some resistant bacteria.
in terms of preparation method, the synthesis method of EMD 1214063 is to synthesize the corresponding enolone compound first, and generate the amine compound by adding dehydrating agent and reacting.
Regarding safety information, the toxicity data 1214063 by EMD is relatively small, so the specific toxicity level and safety measures need to be further studied and determined. However, in any chemical laboratory, when using or handling the compound, you should follow appropriate laboratory safety procedures and wear appropriate personal protective equipment, such as laboratory gloves and protective glasses. In addition, the storage and disposal of compounds should also comply with relevant regulations and regulations. Drug substances should be properly kept to avoid misuse or leakage. For detailed information and recommendations for use of the substance, it is recommended to consult the safety data sheet provided by the chemical supplier or contact the relevant professional.
Last Update：2024-04-09 21:50:46
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Product Name: Tepotinib Request for quotation
CAS: 1100598-32-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
CAS: 1100598-32-0
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: EMD 1214063 Visit Supplier Webpage Request for quotationCAS: 1100598-32-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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