CYM-5541
CYM 5541
CAS: 945128-26-7
Molecular Formula: C19H28N2O2
CYM-5541 - Names and Identifiers
CYM-5541 - Physico-chemical Properties
| Molecular Formula | C19H28N2O2 |
| Molar Mass | 316.44 |
| Density | 1.14±0.1 g/cm3(Predicted) |
| Boling Point | 503.1±38.0 °C(Predicted) |
| Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Appearance | powder |
| Color | white to beige |
| pKa | -2.57±0.20(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| In vitro study | CYM-5541 is a full agonist, able to reach the maximum level of ERK phosphorylation that is observed with S1P. CYM-5541 has an EC 50 of between 72 and 132 nM and exhibits exquisite selectivity over other S1P receptor subtypes: S1P1 EC 50 >10 μM, S1P2 EC 50 >50 μM, S1P4 EC 50 >50 μM, and S1P5 EC 50 >25 μM. CYM-5541 also shows selectivity over a large panel of protein targets, with no significant activities, in the Ricerca profiling panel of 55 GPCRs, ion channels, and transporters. CYM-5541 allowed us to identify an allosteric site where F263 is a key gate-keeper residue for its affinity and efficacy. The novel allosteric hydrophobic pocket may account for the S1P3 selectivity of CYM-5541. |
CYM-5541 - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
CYM-5541 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.16 ml | 15.801 ml | 31.602 ml |
| 5 mM | 0.632 ml | 3.16 ml | 6.32 ml |
| 10 mM | 0.316 ml | 1.58 ml | 3.16 ml |
| 5 mM | 0.063 ml | 0.316 ml | 0.632 ml |
Last Update：2024-01-02 23:10:35
CYM-5541 - Reference Information
| biological activity | CYM5541 (ML249) is a selective S1P3 allosteric receptor agonist with an EC50 of 72-132 nM. |
| Target | Value |
Last Update：2024-04-09 15:16:56
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Spot supply
Product Name: CYM 5541 Visit Supplier Webpage Request for quotationCAS: 945128-26-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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