Calciumhydrogenphosphate,medicinal
calcium hydrogen phosphate dihydrate
CAS: 7789-77-7
Molecular Formula: CaH5O6P
Calciumhydrogenphosphate,medicinal - Names and Identifiers
| Name | calcium hydrogen phosphate dihydrate |
| Synonyms | CALCIUM PHOSPH dicalciurn phosphate Calcium Phosphate Dihydrate Calciumhydrogenphosphate,dih dicalcium phosphate dihydrate Calciumhydrogenphosphate,medicinal Calcium hydrogenphosphate dihydrate Calcium phosphate dibasic dihydrate calcium hydrogen phosphate dihydrate Calcium hydrogen phosphate,agricultural Calcium hydrogen phosphate Dihydrate precipitate Calcii hydrogenophosphas dihydricus, Calcium hydrogen phosphate dihydrate |
| CAS | 7789-77-7 |
| EINECS | 616-542-1 |
| InChI | InChI=1/Ca.H3O4P.2H2O/c;1-5(2,3)4;;/h;(H3,1,2,3,4);2*1H2/q+2;;;/p-3 |
| InChIKey | XAAHAAMILDNBPS-UHFFFAOYSA-L |
Calciumhydrogenphosphate,medicinal - Physico-chemical Properties
| Molecular Formula | CaH5O6P |
| Molar Mass | 172.09 |
| Density | 2.31 |
| Melting Point | 109°C -H₂O |
| Water Solubility | Slightly soluble in water. Soluble in dilute hydrochloric, nitric, and acetic acid. Insoluble in alcohol |
| Solubility | Practically insoluble in water and in ethanol (96 per cent). It dissolves in dilute hydrochloric acid and in dilute nitric acid. |
| Appearance | White crystal |
| Color | White to almost white |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable. Incompatible with acids. |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00149621 |
| Physical and Chemical Properties | White monoclinic crystalline powder. Odorless and tasteless. relative density 2.306(16 ℃) solubility: soluble in dilute hydrochloric acid, dilute nitric acid, acetic acid, slightly soluble in water, insoluble in ethanol. |
| Use | For fertilizer, feed, medicine, can also be used as food additives, toothpaste, etc Used as auxiliary feed for poultry, can promote feed digestion, but also can treat livestock fistula disease, cartilage disease, anemia and so on |
Calciumhydrogenphosphate,medicinal - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 1 |
| TSCA | Yes |
| HS Code | 28352590 |
Calciumhydrogenphosphate,medicinal - Upstream Downstream Industry
| Raw Materials | Silicon dioxide CALCIUM SULFATE HEMIHYDRATE Phosphoric acid Sulfuric acid Calcium carbonate Calcium carbonate Hydrochloric acid Calcium oxide |
Calciumhydrogenphosphate,medicinal - Nature
Open Data Verified Data
White Crystal or powder. Melting point of 190 deg C; d 2. 31. Soluble in dilute hydrochloric acid and dilute nitric acid, slightly soluble in dilute acetic acid, insoluble in water, ethanol. Two crystals of water are lost at 115-120 °c and calcium pyrophosphate is formed when heated above 400 °c. Low hygroscopicity.
Last Update：2024-01-02 23:10:35
Calciumhydrogenphosphate,medicinal - Preparation Method
Open Data Verified Data
disodium hydrogen phosphate dihydrate and potassium dihydrogen phosphate were dissolved in hot water. In addition, calcium chloride hexahydrate was dissolved in water, and the above two solutions were slowly added dropwise to the aqueous solution of potassium dihydrogen phosphate, suction filtered, and the crystals were washed with phosphoric acid, then washed with acetic acid, and dried to obtain calcium hydrogen phosphate dihydrate.
Last Update：2022-01-01 09:01:23
Calciumhydrogenphosphate,medicinal - Introduction
Odorless, tasteless. Soluble in dilute hydrochloric acid, dilute nitric acid, acetic acid, slightly soluble in water, insoluble in ethanol. Two crystal water is lost at 75 ℃ and calcium pyrophosphate is formed when heated above 400 ℃. The hygroscopicity is less.
Last Update：2022-10-16 17:28:51
Calciumhydrogenphosphate,medicinal - Use
Open Data Verified Data
Analytical reagents. It is used as a calcium supplement in food additives and feed additives.
Last Update：2022-01-01 09:01:23
Calciumhydrogenphosphate,medicinal - Safety
Open Data Verified Data
is irritating. Use should avoid inhalation of dust, avoid contact with the eyes and skin. Store in a cool, ventilated warehouse. Fire, can use water, sand, carbon dioxide fire extinguishing.
Last Update：2022-01-01 09:01:24
Calciumhydrogenphosphate,medicinal - Reference Information
| solubility in water (g/100ml) | grams dissolved per 100ml of water: 4.303 × 10-3/20 ℃ |
| toxicity | Adl 0~70 mg/kg (calculated as phosphorus), used for biscuits, milk substitutes, the usage amount is in accordance with the needs of normal production. Adl 0-70 mg/kg (calculated as phosphorus). |
| Application | used as feed and food additives, gypsum friction agent, plastic stabilizer and drug additives, mainly used as fertilizer, can be used in acidic, slightly acidic or neutral soil, suitable for all kinds of crops. It is also used as a stabilizer for plastics. It is mainly used as a friction agent in the manufacture of advanced toothpaste. In the toothpaste formula accounted for 40% ~ 50%. used as auxiliary feed for poultry, can promote feed digestion, make poultry weight gain, to increase meat production, milk production, egg production, but also can treat livestock rickets, rickets, anemia, etc. used as analytical reagent and plastic fixative as tablet diluent and absorbent. used for fertilizer, feed, medicine, can also be used as food additives, toothpaste fillers used as poultry auxiliary feed, can promote feed digestion, but also can treat livestock fistula disease, osteochondrosis, anemia and so on in the food industry as a coagulant for biscuits, milk substitutes, the use of normal production needs. It is also used as a yeast culture agent in bread making. Also used as dough improver, nutritional supplements. It is mainly used as a tablet filler and adsorbent, and is used as a supplement for the lack of calcium and phosphorus in the human body. |
| production method | by double decomposition method, the qualified phosphoric acid for defluorination, arsenic and heavy metals is neutralized with edible soda ash solution, A desired mixed solution of sodium dihydrogen phosphate and disodium hydrogen phosphate was obtained and fed to a reactor with a high-speed stirring device. The purified and decolorized calcium chloride solution was then added under high-speed stirring for metathesis reaction. Then, a purified decolorized soda ash solution was added for neutralization. After the end of the reaction, after rinsing, centrifugal dehydration, drying, grinding, preparation of medicinal calcium hydrogen phosphate products. 4H3PO4+3Na2CO3 → 2Na2PHO4+2Na2HPO4 + 3H2O +3CO2+2NaH2PO4 + CaCl2 → Ca(H2PO4)2 + 2nac1ca (H2PO4)2 + Na2CO3 → CaHPO4 + Na2HPO4 + H2O + CO2 + Na2HPO4 + CaCl2 → CaHPO4 + 2NaCl by double decomposition method, the qualified phosphoric acid after defluorination and arsenic removal is neutralized with edible soda ash, the mixed solution of sodium dihydrogen phosphate and disodium hydrogen phosphate is sent into the reactor with high-speed stirring device, the purified decolorized calcium chloride solution is added under high-speed stirring for double decomposition reaction, and then the purified decolorized soda ash solution is added for neutralization, the reaction product was rinsed, centrifuged, dried and crushed to obtain edible calcium hydrogen phosphate. 4H3PO4+3Na2CO3 → 2NaH2PO4+2Na2HPO4 + 3H2O +3CO2+2NaH2PO4 + CaCl2 → CaC12PO4)2 +2NaClCa(H2PO4)2 + Na2CO3 → CaHPO4 + Na2HPO4 + H2O + CO2 + Na2HPO4 + CaCl2 → CaHPO4 + 2NaCl The thermal phosphoric acid containing 470% ~ 80% H3PO was heated to 40~50 by direct mixing reaction method ℃, the mixture was mixed with 100 mesh calcite containing 95% CaCO3 in a mixer and reacted vigorously to form a mixture of calcium hydrogen phosphate and calcium dihydrogen phosphate. After the material is chopped and aged, the remaining calcium carbonate and calcium dihydrogen phosphate in the material are converted into calcium hydrogen phosphate as much as possible. Then, it is dried in a rotary kiln to contain less than 3% of free water, and then pulverized to obtain calcium hydrogen phosphate for feed. Its 2H3PO4+2CaCO3 → 2 CaHPO4? 2H2O +2CO2 two stage neutralization method to extract phosphoric acid as raw material to be purified. The purpose of purifying phosphoric acid is to use limestone powder to precipitate step by step. That is, in the first stage, 70% ~ 75% of the limestone suspension is neutralized by adding a human neutralizer and extracting phosphoric acid, so that 40% ~ 65% P2O5 is precipitated, and after filtration, the filtrate is sent to the second stage neutralizer, and then the remaining limestone suspension is added for neutralization reaction to precipitate calcium hydrogen phosphate for feed, which is filtered and the filter cake is sent to dry to prepare calcium hydrogen phosphate for feed. Its 2H3PO4+2CaCO3 → 2 CaHPO4? The mixed solution of sodium dihydrogen phosphate and disodium hydrogen phosphate meeting the neutralization requirements is fed into the reactor with high-speed stirring device by the double decomposition method of 2H2O +2CO2 , the purified decolorized calcium chloride solution, which is slightly less than the theoretical amount of the chemical reaction, is then added under high-speed stirring for mixing. Then, the purified and decolorized soda ash solution is added at a higher speed to carry out neutralization reaction. When the pH value rises to 4, the rate of adding alkali is reduced, and the method of adding and stopping is adopted, the end point was determined with a mixed indicator (methyl red and methyl blue mixed indicator changed from purple to light green). After completion of the reaction, by rinsing, adding stabilizer (magnesium sulfate and sodium pyrophosphate), and then rinsing, centrifugal dehydration, air flow drying, jet grinding, to prepare finished calcium hydrogen phosphate for toothpaste. 4H3PO4+3Na2CO3 → 2NaH2PO4+2Na2HPO4 + 3H2O +3CO2+2NaH2PO4 + CaCl2 → Ca(H2PO4)2 + 2NaClCa (H2PO4)2 + Na2CO3 → CaHPO4 + Na2HPO4 + H2O + CO2 + Na2HPO4 + CaC12 → CaHPO4 + 2NaCl, the charring of the bone residue is complete at a high temperature above 900 °c. The iron residue and the stone in the carbonized bone residue were picked out, and a suspension was prepared with water, and hydrochloric acid was added for acid hydrolysis. The acid solution was adjusted to Ph 2 with soda ash to remove impurities such as iron and fluoride ions, and bleaching powder was added to decolor and further remove iron. Filtered to a colorless transparent liquid. The relative density of the solution was controlled to be 1.26(25 ° C.) and Ph 1.3-1.5. The above solution was subjected to a neutralization reaction with a purified decolorized soda ash solution at a temperature below 60 °c. After initial washing, the neutralized liquid was added with magnesium sulfate and sodium pyrophosphate stabilizer, aged for 20 min, and then washed with water until the finished chloride ion was qualified. After centrifugal dehydration, drying and grinding, calcium hydrogen phosphate finished toothpaste was prepared. Ca3(PO4)2 + 6HCl → 2H3PO4 4 → 3CaC12H3PO4 + Na2CO3 + CaCl2 → CaHPO4 + 2NaCl + H2O + CO2 no filtration, no defluorination, one-stage neutralization method, phosphate rock powder of 40~80 mesh and 15% ~ 20% hydrochloric acid was measured and added into the extractor with stirring, phosphate rock powder reacts with hydrochloric acid to generate phosphoric acid and calcium chloride. After the reaction, the liquid is extracted, and the liquid overflow is neutralized, and a certain amount of milk of lime solution (calcium oxide 80g/L) is added. Alternatively, a 200 mesh limestone powder suspension is neutralized to Ph = 4-5 below 50 °c to completely precipitate PO43. The obtained precipitate was separated by centrifugation after thickening and sedimentation, and then washed with water to obtain a finished calcium hydrogen phosphate for fertilizer. Ca5F(PO4)3 + 10HCl → 3h3po4+5cacl2 + HF +2H3PO4 + Ca(OH)2 → Ca(H2PO4)2 + 2h2oca (H2PO4)2 + Ca(OH)2 → 2 CaHPO4? 2H2O Monocalcium phosphate method the superphosphate is leached for 10~15 min at (35±5)℃ with water stirring, then centrifuged, and phosphogypsum is discarded to obtain Monocalcium phosphate solution, defluorination was carried out by adding sodium chloride (about 40g per liter of solution plus sodium chloride), controlling the defluorination temperature at (45±5) °c, stirring for 30 min, and then settling for about 1H. After defluorination, the mono-calcium phosphate solution is added into a milk of lime solution containing calcium oxide 80g/L for stirring and neutralization, and the pH value is controlled at about 2-2.5, and the neutralization temperature is not higher than 40 ℃, the calcium hydrogen phosphate precipitate is generated, and the product of calcium hydrogen phosphate for fertilizer is prepared by centrifugal separation. |
Last Update：2024-04-09 02:00:11
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