Carbacholine
Carbachol
CAS: 51-83-2
Molecular Formula: C6H15N2O2.Cl
Carbacholine - Names and Identifiers
Carbacholine - Physico-chemical Properties
| Molecular Formula | C6H15N2O2.Cl |
| Molar Mass | 182.65 |
| Density | 1.2798 (rough estimate) |
| Melting Point | 210 °C (dec.) (lit.) |
| Water Solubility | 1.0 G/ML |
| Solubility | H2O: 1 g/mL |
| Appearance | crystalline |
| Color | white |
| Merck | 14,1779 |
| BRN | 3917459 |
| pKa | pKa 4.8 (Uncertain) |
| Storage Condition | Desiccate at RT |
| Sensitive | Hygroscopic |
| Refractive Index | 1.5557 (estimate) |
| Physical and Chemical Properties | Chemical properties of prismatic crystals. Melting Point 204-205 °c. Each gram of the product can be dissolved in 1ml water, 50ml ethanol, 10ml methanol; Almost insoluble in chloroform, ether, aqueous solution was neutral. Hygroscopicity, a weak fatty amine odor. |
| Use | The application is suitable for intraocular lens implantation, cataract extraction, corneal transplantation and other ophthalmic operations requiring miosis, and can also be used for glaucoma. |
Carbacholine - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R25 - Toxic if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S28A - S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | GA0875000 |
| TSCA | Yes |
| HS Code | 29239000 |
| Hazard Class | 6.1 |
| Packing Group | II |
| Toxicity | LD50 in mice (mg/kg): 15 orally, 0.3 i.v. (Molitor) |
Carbacholine - Upstream Downstream Industry
Carbacholine - Uses and methods of synthesis
cholinergic agent
carbachol (carbachol) is a synthetic cholinergic drug, which can directly act on the pupillary sphincter to produce an immediate miotic effect, and has an anticholinesterase effect, can maintain a long time of miotic. Can also prevent intraocular pressure after intraocular lens implantation, cataract extraction and other eye surgery.
preparation method
β-chloroethyl chloroformate was obtained from β-chloroethanol by phosgenation, and then reacted with ammonia to produce β-chloroethyl carbamate, finally, it is obtained by reacting with trimethylamine to form a quaternary ammonium salt.
adverse reactions
common side effects were blurred vision, eye pain, corneal opacity, persistent corneal Bulla lesions, postoperative iritis, eye irritation or burning sensation; Head Pain, eye irritation or congestion, eyelid twitching were found occasionally. The above symptoms can generally disappear by itself.
contraindication
1. Allergic to this product is contraindicated.
2. Cardiovascular diseases including arrhythmia, bradycardia, hypotension patients and vagal nerve excitation, epilepsy, hyperthyroidism, Parkinson's disease, bronchial asthma, peptic ulcer and urinary tract infarction patients disabled.
note
1. Injection for ophthalmic use of drugs, not oral, intramuscular and intravenous injection.
2.FDA's pregnancy safety rating for this drug is C.
Drug interactions
eye local use of non-steroidal anti-inflammatory drug treatment, the use of this product is invalid.
specification
injection: 1 ml: 0.25 mg; Eye drops: 0.75% ~ 3%.
production method
β-chloroethyl chloroformate was obtained from β-chloroethanol by phosgenation, and then reacted with ammonia to produce β-chloroethyl carbamate, finally with trimethylamine into quaternary ammonium salt reaction to get Carbachol: Carbachol is another method of preparation of choline chloride and urea as raw materials: when using ingredients than choline chloride: urea: sodium nitrite: sulfuric acid = 1: carbachol was obtained in a yield of 1.15 at 1: 1.35: 71% for about 40H at 60 °c.
category
toxic substances
toxicity grade
highly toxic
Acute toxicity
oral-rat LD50: 40 mg/kg; Oral-mouse LD50: 15 mg/kg
flammability hazard characteristics
thermal decomposition of toxic nitrogen oxides, chloride smoke
storage and transportation characteristics
The warehouse is ventilated and dried at low temperature; It is stored separately from food raw materials
fire extinguishing agent
water, carbon dioxide, foam, dry powder
Last Update：2024-04-10 22:29:15
Carbacholine - Nature
| NIST chemical substance information | Carbachol(51-83-2) |
| EPA chemical substance information | Carbachol chloride (51-83-2) |
Last Update：2024-04-09 01:59:51
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