Cardamoni
CARDAMONIN
CAS: 18956-16-6;19309-14-9
Molecular Formula: C16H14O4
Cardamoni - Names and Identifiers
| Name | CARDAMONIN |
| Synonyms | Cardamoni CARDAMONIN Alpinetin chalcone -3-phenylprop-2-en-1-one 1-(2,4-Dihydroxy-6-methoxyphenyl) Chalcone, 2', 4'-dihydroxy-6'-methoxy- (E)-1-(2,4-Dihydroxy-6-methoxy-phenyl)-3-phenyl- (E)-1-(2,4-DIHYDROXY-6-METHOXY-PHENYL)-3-PHENYL-PROPENONE 1-(2,4-Dihydroxy-6-Methoxyphenyl)-3-phenylprop-2-en-1-one 2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl- (2E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one |
| CAS | 18956-16-6 19309-14-9 |
| InChI | InChI=1/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+ |
Cardamoni - Physico-chemical Properties
| Molecular Formula | C16H14O4 |
| Molar Mass | 270.28 |
| Density | 1.282±0.06 g/cm3(Predicted) |
| Melting Point | 178 °C |
| Boling Point | 484.5±45.0 °C(Predicted) |
| Flash Point | 182.7°C |
| Solubility | Soluble in DMSO, slightly soluble in methanol |
| Vapor Presure | 5.2E-10mmHg at 25°C |
| Appearance | Yellow powder or crystal |
| pKa | 7.00±0.40(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.657 |
| MDL | MFCD00238554 |
Cardamoni - Reference
| Reference Show more | 1. [IF=2.882] Mohammed Khaled Bin Break et al."Discovery of a highly active anticancer analogue of cardamonin that acts as an inducer of caspase-dependent apoptosis and modulator of the mTOR pathway."Fitoterapia. 2018 Mar;125:161 |
Cardamoni - Reference Information
| overview | cardamom (cardamonin,CDN), with a structure of 2',4'-dihydroxy-6'-methoxychalcone, mainly anti-platelet aggregation, anti-tumor, anti-mutagenic, anti-inflammatory, antioxidant and antibacterial biological activities. A large number of studies have shown that the inhibitory effect of cardamom on inflammatory mediators prostaglandin E2(PGE2), nitric oxide (NO), tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 is related to the inhibition of NF-κB signaling pathway. TLR4 is the upstream regulatory gene of NF-κB, and the regulatory effect of cardamom on TLR4/NF-κB signaling pathway is only found in our previous research report: the protective effect of cardamom on inflammatory damage of colon mucosa in mice may be related to down-regulation of TLR4 expression in colon tissue, inhibition of NF-κB and mitogen-activated protein kinase activity and reduction of inflammatory mediator release. |
| biological activity | Cardamonin (Alpinetin chalcone) naturally exists in the fruits of ginger species and has anti-inflammatory and anti-tumor activities. It is a novel hTRPA1 ion channel antagonist, IC50 is 454 nM, but does not interact with TRPV1 and TRPV4. |
| Target | Value |
| hTRPA1 () | 454 nM |
Last Update：2024-04-09 21:32:04
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