Carnosol
Carnosol
CAS: 5957-80-2
Molecular Formula: C20H26O4
Carnosol - Names and Identifiers
Carnosol - Physico-chemical Properties
| Molecular Formula | C20H26O4 |
| Molar Mass | 330.42 |
| Density | 1.26±0.1 g/cm3(Predicted) |
| Melting Point | 240～242℃ |
| Boling Point | 524.8±50.0 °C(Predicted) |
| Specific Rotation(α) | +415°(c=0.1,chloroform) |
| Flash Point | 187°C |
| Solubility | Soluble in ethanol, acetone and grease, insoluble in water. |
| Vapor Presure | 1.24E-11mmHg at 25°C |
| Appearance | Yellow to tan powder |
| pKa | 8.91±0.40(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.606 |
| MDL | MFCD02752467 |
| Physical and Chemical Properties | Yellow powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Rosmarinus officinalis office is L. |
| In vitro study | It is showed that carnosol has no cytotoxic effects on GES1 cells and 10 μM carnosol strongly suppresses RSK2 activity, but has little effect on any other kinase. Carnosol exerts strong dose-dependent inhibitory effects against RSK2 autophosphorylation and phosphorylation of its substrate ATF1. |
| In vivo study | Results indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged. |
Carnosol - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29322090 |
Carnosol - Reference
| Reference Show more | 1. Wenwen, Wang Wenqing, Wu Hua, Wang Chunling, Chen Xiaodi, Xu Min, Xiao Junsong. Antioxidant effect of fat-soluble Rosemary antioxidant on oil and fresh pork [J]. China Oils, 2021,46(03):142-148. 2. Wang, Jixia, et al. "Discovery of new targets of pH acids in danshen using a label-free cell phenotypic assay." RSC Advances 5.33 (2015): 25768-25776.https:// doi.org/10.1039/C4RA16102E 3. [IF = 3.049] Jixia Wang et al. "Discovery of new targets of pH acids in danshen using a label-free cell phenotypic assay. Rsc Adv. 2015 Mar;5(33): 25768-25776 |
Carnosol - Introduction
Pharmacological effects: Inhibit the decomposition of peroxypolyene fatty acids of oils and fats.
Last Update：2022-10-16 17:26:48
Carnosol - Reference Information
| Plant Source: | Rosemary |
| Introduction | carnosol, is a kind of natural diterpenoid compounds in rosemary and Salvia miltiorrhiza and other plants, has a strong hypolipidemic, antioxidant, anti-tumor, antiviral and anti-inflammatory properties, has been widely used in health care, food, natural pigment, in the field of cosmetics and the like, it has been reported that Sage bitter fat can have anti-tumor effect by inhibiting NF-κB pathway, and can also induce apoptosis of T cell leukemia and lymphoma cells and reduce serum levels of IL-6 and TNF-α. |
| preparation | take the dried rosemary leaves and branches of 2000G, add 14L petroleum ether, reflux extract 3 times, each time for 3 hours, combine the extract for 3 times, concentrate and recover the petroleum ether to obtain the extract; Dissolve the extract with 40% ethanol, filter to remove the insoluble matter, and obtain 1000ml mother liquor as the adsorption liquid, which is adsorbed with 500mlD101 macroporous adsorption resin, after the adsorption is completed, the eluent is eluted with 1000ml of purified water, and then 90% ml of ethanol solution. The eluent is divided into 6 sections, and the Middle 4 parts are combined; The combined eluent is concentrated to 100ml under reduced pressure, and 200ml of water is added, precipitate is precipitated by stirring and left for 3 hours; Precipitate is obtained by centrifugation to contain carnosus Thunb. The precipitate is dissolved with 200ml of ethyl acetate, 200ml of petroleum ether is added thereto, and the precipitate is precipitated by stirring; the crude carnosus thunbergii internal fat was obtained by filtration, and the crude product was crystallized with 13.6 ml of anhydrous ethanol to obtain the crystal of carnosus thunbergii internal fat. After filtration and drying, g of crystal was obtained, the content of internal lipid of Salvia officinalis was 96.1% by HPLC. |
| biological activity | Carnosol is a potent inhibitor of ribosomal S6 kinase (RSK2), which can be used in gastric cancer related research, its IC50 value is about 5.5 μm. Carnosol is an activator of Nrf2, which increases the level of Nrf2 and promotes the expression of heme oxygenase 1 (HMOX1). |
| Use | carnosol has anti-radiation, anti-oxidation, anti-cancer effect. for content determination/identification/pharmacological experiments and other pharmacological effects: inhibition of lipid peroxidation polyene fatty acid decomposition |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:45:29
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Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Carnosol Visit Supplier Webpage Request for quotationCAS: 5957-80-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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