Catharanthine Tartrate
Catharanthine Tartrate
CAS: 4168-17-6
Molecular Formula: C25H30N2O8
Catharanthine Tartrate - Names and Identifiers
Catharanthine Tartrate - Physico-chemical Properties
| Molecular Formula | C25H30N2O8 |
| Molar Mass | 486.51 |
| Melting Point | 145-1470C |
| Solubility | DMSO (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated, S |
| Appearance | Powder |
| Color | White to Pale Beige |
| Storage Condition | Inert atmosphere,2-8°C |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Catharanthus roseus. |
Catharanthine Tartrate - Reference Information
| Application | vinblastine tartrate is vinblastine tartrate. Is one of the vinca alkaloids, animal experiments show that it has antihypertensive effect, is widely used in the synthesis of anticancer drugs vinorelbine tartrate, vinblastine sulfate and vincristine one of the important starting materials, it has a wide range of applications. |
| preparation | A preparation method of vinblastine tartrate, which takes fresh whole Vinca as starting material, increase the content of vinblastine, through extraction, pH extraction separation and purification can get about 78% purity of vinblastine crude, and then through salt, recrystallization can directly get more than 99% of high purity, and easy-to-preserve vinblastine tartrate. The specific technical scheme is as follows: (1) take the fresh whole plant of Catharanthus roseus and soak it with sodium chloride aqueous solution by ultrasound, then take out directly into the flow rate of 5-8M/s -15 ~-25 ℃ cold air freeze-drying, freeze-drying after the Vinca whole plant crushing; (2) add the whole Catharanthus roseus powder of step (1) to water, adjust the pH to 1.3-1.6, sonicate for 2-3H, filter the filtrate, adjust the pH of the filtrate to 8-9, then, in the form of spraying from the top of the extraction tank, while the extraction agent is sprayed from the lower part of the extraction tank in the form of spraying, and the organic phase is collected after the extraction is completed; The extraction agent is a mixture of N-bromopropane and ethanol; (3) removing the solvent from the organic phase under reduced pressure, completely dissolving the residue with anhydrous ethanol, adjusting the pH to 3.8-4.1 by adding an ethanol solution of sulfuric acid, standing and separating, and taking the filtrate; (4) The filtrate of step (3) is evaporated to dryness under reduced pressure, the residue is dissolved in water, adjusted to pH 1.5-2.5, and stirred until the solution is clear, then it is extracted with the mixture of dichloromethane and ethyl acetate, the water phase is taken, the water phase is adjusted to pH 4.5-4.8, then it is extracted with the mixture of toluene and petroleum ether, and the obtained organic phase is evaporated to dryness under reduced pressure, (5) the crude vinblastine was dissolved in methanol, and then the methanol solution of tartaric acid was added thereto, followed by ultrasonic reaction and crystallization, vinblastine tartrate; (6) the vinblastine tartrate is added to N,N-dimethylformamide, heated to full solution, then the mixture of methanol and ethyl acetate is added, stirred evenly and recrystallized, the obtained crystals were pure vinblastine tartrate. |
| biological activity | Catharanthine Tartrate is the alkaloid substance in the periwinkle, inhibition of voltage-gated L-type calcium channel (voltage-operated L-type Ca2 channel), with anti-tumor, hypotensive activity. |
| Use | vinblastine tartrate has hypoglycemic and antitumor effects. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: for Hodgkin's disease, Chorion nerve epithelial cancer curative effect is good, for acute leukemia, breast cancer, ovarian cancer, testicular cancer, head and neck cancer, oropharyngeal cancer, monocytic leukemia have certain curative effect. |
Last Update：2024-04-09 21:01:54
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Tel: 18301782025
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Mobile: 18021002903
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