Cefdinir
Cefdinir
CAS: 91832-40-5
Molecular Formula: C14H13N5O5S2
Cefdinir - Names and Identifiers
Cefdinir - Physico-chemical Properties
| Molecular Formula | C14H13N5O5S2 |
| Molar Mass | 395.41 |
| Density | 1.89±0.1 g/cm3(Predicted) |
| Melting Point | >180°C dec. |
| Water Solubility | Soluble in water |
| Solubility | dilute HCl: slightly soluble |
| Appearance | solid |
| Color | Pale Yellow to Light Yellow |
| Maximum wavelength(λmax) | ['295nm(DMSO)(lit.)'] |
| Merck | 14,1920 |
| pKa | 9.70(at 25℃) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.861 |
| Physical and Chemical Properties | White to yellowish crystalline powder, odorless or slightly smelly, almost insoluble in ethanol, ether or water. Melting point 170 ℃ (decomposition). UV maximum absorption (Ph = 7 phosphate buffer):223,186ran(ε 17400,19700). pKa9.70, cefdinir sodium ((3efdinir Sodium):C14H12N5O5S2Na. Melting point 220 ℃ (decomposition). |
| Use | This product is for scientific research only and shall not be used for other purposes. |
Cefdinir - Risk and Safety
| WGK Germany | 3 |
| RTECS | XI0367250 |
| HS Code | 2941906000 |
| Toxicity | LD50 orl-rat: >5600 mg/kg IYKEDH 23,93,1992 |
Cefdinir - Nature
Open Data Verified Data
white to yellowish crystalline powder, odorless or slightly odorless. Melting point 170 °c (decomposition). pK. 9.70. Semi-synthetic third-generation cephalosporins. White crystalline powder. Slightly soluble in phosphate buffer, dilute hydrochloric acid, almost insoluble in water, methanol, ethanol, acetone and other general organic solvents, no obvious melting point.
Last Update：2024-01-02 23:10:35
Cefdinir - Preparation Method
Open Data Verified Data
using 7-ACA as a raw material, after protecting the 7-position amino group and the 2-position carboxyl group, it reacts with triphenylphosphorus to obtain a phosphide, which reacts with formaldehyde under alkaline conditions to obtain a vinyl derivative at the 3-position. This was treated with hydrochloric acid to give the compound. This compound is reacted with 4-bromoacetyl bromide in ethyl acetate in the presence of N-methylsilyl acetamide to give an acylated product. The obtained acylated product was added to dichloromethane and acetic acid, and nitrosation was carried out with an aqueous solution of sodium nitrite, followed by the addition of urea to destroy excess sodium nitrite to obtain a hydroxylamine compound. The hydroxylamine compound is reacted with thiourea in N,N-methylacetamide to give a crude compound. The crude compound was reacted with trifluoroacetic acid in anisole and recrystallized to obtain cefdinir.
Last Update：2022-01-01 08:52:31
Cefdinir - Standard
Authoritative Data Verified Data
(6R,7R)-7-[(2-amino-4-thiazolyl)-(oxime) acetyl] amino]-3-vinyl-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2-carboxylic acid. The content of cefdinir (C14H13N505S2) shall not be less than 94.0% calculated as anhydrous.
Last Update：2024-01-02 23:10:35
Cefdinir - Trait
Authoritative Data Verified Data
- This product is a yellowish to yellow crystalline powder; It has slight odor.
- This product is insoluble in water, ethanol or ether, in 0.lmol/L phosphate buffer [0.1 mol/L disodium hydrogen phosphate solution -0.1 mol/L potassium dihydrogen phosphate solution (2:1)] slightly soluble.
specific rotation
take this product, precision weighing, add the above 0.1 mol/L phosphate buffer solution was dissolved and quantitatively diluted to prepare a solution containing about 10 mg per 1 ml, which was measured according to law (General rule 0621), and the specific rotation was from one 58 ° to one 66 °.
absorption coefficient
take this product, precision weighing, add the above 0.1 mol/L phosphate buffer solution and quantitative dilution of about 10ug per 1 ml of solution, according to UV-visible spectrophotometry (General 0401), determination of absorbance at 287nm wavelength, the absorption coefficient is 570 to 610.
Last Update：2022-01-01 11:39:40
Cefdinir - Quality standards-Chinese Pharmacopoeia 2005 edition
Open Data Verified Data
The content of cefdinir (C14 H & uml; Ns OS S2) shall not be less than 94.0% calculated as anhydrous. PH, pH value should be 2.5~4.5. Water content should not exceed 2.0%; Ignition residue, residue should not exceed 0.2%. Containing heavy metals should not exceed 0.001%.
Last Update：2022-01-01 08:52:32
Cefdinir - Differential diagnosis
Authoritative Data Verified Data
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1122).
Last Update：2022-01-01 11:39:40
Cefdinir - Use
Open Data Verified Data
developed by Japan Fujisawa Pharmaceutical Industry Co., Ltd., launched in October 19, 91. In December 1 99, cefdinir was approved by the US FDA for marketing in the US under the trade name Omnicef. Cefdinir is obtained by structural modification based on cefixime, which makes up for the weak effect of the original third generation cephalosporins on Gram-positive bacteria. It has excellent antibacterial effect on Gram-positive and gram-negative bacteria. For Transmissibility impetigo, erysipelas, subcutaneous abscess, mastitis, trauma and postoperative surface infection, pharyngitis, acute bronchitis, Pneumonia, tonsillitis, urethritis, intrauterine infection.
Last Update：2022-01-01 08:52:32
Cefdinir - Exam
Authoritative Data Verified Data
crystallinity
take a small amount of this product, according to the law inspection (General 0981), should comply with the provisions.
acidity
take about 0.2g of this product, add water 20ml, make a uniform suspension, according to the law (General 0631),pH value should be 2.5~4.5.
Related substances
operation in the dark. Precision weighing this product about 37.5mg, put 25ml brown measuring bottle, add the above 0. After dissolving 4ml of lmol /L phosphate buffer solution, dilute to the scale with mobile phase A, shake well and use it as A test solution, dilute to the scale with mobile phase A, shake, as A control solution; Precision take the appropriate amount of control solution, quantitative dilution with mobile phase A to make A solution containing about 0.75ug per 1ml, as A sensitivity solution. According to the high performance liquid chromatography (General rule 0512) test, silica gel bonded with eighteen alkyl silane was used as the filler; Mobile phase A was 0.25% of 5.5 tetramethylammonium hydroxide solution (adjusted to pH with phosphoric acid), and 0.1 mol/L ethylenediamine tetraacetic acid disodium solution 0.4, mobile phase B 0.25% tetramethylammonium hydroxide solution (with phosphoric acid to adjust the pH value to 5.5)-acetonitrile-methanol (500:300:200), add 0 per 1000ml. 1 mol/L ethylenediamine tetraacetic acid disodium solution 0.4, according to Table 1 for linear gradient elution. The column temperature was 40°C and the detection wavelength was 2541101. Take cefdinir control about 37.5mg, put 25ml brown measuring flask, add 0. After dissolving 4ml of lmol /L phosphate buffer solution, dilute to the scale with mobile phase A, shake well, heat in A water bath for about 35 minutes, prepare a mixed solution containing about 1.5mg of cefdinir and its degradation impurities per 1mL (wherein the amounts of impurities I, J, K, L are about 2% each), take 20u1 injection liquid chromatograph, record chromatogram should be basically consistent with the system applicable solution typical chromatogram, cefdinir peak retention time is about 22 minutes, the separation degree of cefdinir peak and impurity J peak should be not less than 1.2, impurity I peak and impurity J peak, the separation degree between cefdinir peak and impurity K peak and impurity K peak and impurity L peak shall meet the requirements. The sensitivity solution 20u1 was injected into the human liquid chromatograph, and the chromatogram was recorded. The signal-to-noise ratio of the peak height of the principal component should be greater than 10. 20 u1 of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatograms were recorded. If there are impurity peaks in the chromatogram of the test solution, the area of the impurity peak shall be in accordance with the limit requirements in table 2 when compared with the area of the main peak of the control solution, the sum of each impurity peak area shall not be greater than 3.0 times (3.0%) of the main peak area of the control solution. The peaks in the chromatogram of the test solution which are smaller than the main peak area of the sensitivity solution are ignored.
moisture
take this product, add the mixed solution of formamide and methanol (2:1) to dissolve, according to the method of determination of moisture (General Principles 0832 first method 1), the water content shall not exceed 2.0%.
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.2%.
Last Update：2022-01-01 11:39:41
Cefdinir - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with octanoalkyl silane as filler; 0.25% tetramethylammonium hydroxide solution (adjusted to pH 5.5 with phosphoric acid)-acetonitrile-methanol (900:60:40 ) , add 0 per 1000ml. The mobile phase was ethylene diamine tetraacetic acid disodium solution (lmol/L, 0.4ml), and the detection wavelength was 254nm. Take about 20mg of cefdinir control, put it in a 100ml brown measuring flask, and add 0. After dissolving 2ml of lmol/L phosphate buffer solution, dilute to scale with mobile phase, shake well, heat in water bath for about 35 minutes, to obtain a mixed solution containing about 0.9 mg of cefdinir and its degradation impurities per 1 mL (wherein the amount of impurities at the retention time of 1.2 and of the relative main peak is about 2% respectively), 20u1 was injected into human liquid chromatograph, and the chromatogram was recorded. The retention time of cefdinir peak was about 8 minutes, and the retention time of E-isomer peak was about 3.5 times of cefdinir peak, the separation degree of cefdinir peak and its impurity peak at relative retention time 0.9 and 1.2 should be not less than 1.20.
assay
take this product about 20mg, precision weighing, 100ml brown flask, add the above 0. After dissolving 2ml of lmol/L phosphate buffer solution, dilute to scale with mobile phase, shake well, and use 20u1 as sample solution to record chromatogram; an appropriate amount of cefdinir reference substance was taken and determined by the same method. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:39:42
Cefdinir - Category
Authoritative Data Verified Data
B-lactam antibiotics, cephalosporins.
Last Update：2022-01-01 11:39:42
Cefdinir - Storage
Authoritative Data Verified Data
shade, seal, and store in a cool place.
Last Update：2022-01-01 11:39:42
Cefdinir - Cefdinir Capsules
Authoritative Data Verified Data
This product contains cefdinir C14H13N505S2 should be 90.0% ~ 110.0% of the label children.
trait
The content of this product is light yellow or yellow powder or granules.
identification
- the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution in the chromatogram recorded under the item containing the director.
- take an appropriate amount of the content of this product (about 10mg equivalent to cefdinir), put it in a 100ml measuring flask, add 0.lmol/L phosphate buffer [0.1 mol/L disodium hydrogen phosphate solution -0.1 mol/L potassium dihydrogen phosphate solution (2:1 )] was dissolved and diluted to the scale, shaken, filtered, and the appropriate amount of filtrate was taken, A solution containing about 10ug of cefdinir per 1 ml diluted with the above solvent has a maximum absorption at wavelengths of 287nm and 224nm as determined by UV-Vis spectrophotometry (General 0401), there is minimal absorption at a wavelength of 248nm.
examination
- the contents under the item of difference in loading amount of related substances shall be handled in the dark and mixed evenly, and an appropriate amount (about 37.5mg equivalent to cefdinir) shall be accurately weighed and placed in a 25ml Brown measuring flask, add above 0. After dissolving cefdinir in 4ml of 1 mol/L phosphate buffer solution, dilute to the scale with mobile phase A, shake and filter, and take the continued filtrate as the test solution, if there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak is compared with the area of the main peak of the control solution, all shall meet the limit requirements in Table 2 below of cefdinir, and the sum of the peak areas of each impurity shall not be greater than 3.5 times (3.5%) of the main peak area of the control solution. The peaks in the chromatogram of the test solution which are smaller than the main peak area of the sensitivity solution are ignored.
- loss on drying: take an appropriate amount of the contents of this product, use phosphorus pentoxide as desiccant, and dry under reduced pressure at 60°C to a constant weight, and lose no more than 3.0% of the weight (General rule 0831).
- dissolution dissolution of this product, according to the dissolution and release determination method (General rule 0931 second method), hydrochloric acid solution (dilute hydrochloric acid 24 -1000)900ml as the dissolution medium, the rotation speed is 50 revolutions per minute, and the operation is carried out according to law. After 30 minutes, the appropriate amount of the solution is taken, filtered, and the appropriate amount of the filtrate is accurately taken and placed in a brown measuring flask, A solution containing about 10ug of cefdinir per 1 ml was prepared by quantitative dilution with dissolution medium, and the absorbance was measured at the wavelength of 280nm by ultraviolet-visible spectrophotometry (General rule 0401); in addition, the appropriate amount of cefdinir reference product was accurately weighed and placed in a brown measuring flask. lmol/L phosphate buffer solution and diluted with dingtong to make a solution containing about 0.25mg per lml, the solution containing about 10ug per lml is prepared by quantitative dilution with dissolution medium, and the dissolution amount of each granule is calculated by the same method. The limit is 75% of the labeled amount, and the provisions shall be met.
- others should comply with the relevant provisions under the capsule (General 0103).
Content determination
take the contents under the difference of loading, mix evenly, weigh an appropriate amount (about 0.lg equivalent to cefdinir) accurately, put it in a 100ml brown measuring flask, and add 0. After dissolving 10ml of lmol/L phosphate buffer solution, dilute to the scale with mobile phase, shake well, filter, Take 5ml of filtrate accurately, put it in a 25ml brown measuring flask, dilute to the scale with mobile phase, as a swab solution. According to the method under the cefdinir determination, obtained.
category
with cefdinir.
specification
O.lg
storage
shade, seal, and store in a cool place.
Last Update：2022-01-01 11:39:43
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Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Cefdinir Request for quotation
CAS: 91832-40-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 91832-40-5
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
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Product Name: Cefdinir Visit Supplier Webpage Request for quotationCAS: 91832-40-5
Tel: 18301782025
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