Chloroformate - Names and Identifiers
Chloroformate - Physico-chemical Properties
| Molecular Formula | CHClO2
|
| Molar Mass | 80.47044 |
Chloroformate - Introduction
A chrooformate is a class of organic compounds with the chemical formula RCOCl, where R represents an organic group. Such compounds are usually volatile, colorless or yellowish liquids or solids.
Chloroformate is commonly used as a reagent for organic synthesis reactions, especially for esterification and carboxylic acid esterification reactions. It can be used as an esterification reagent or as a chlorination reagent because of its ease of substitution reactions with nucleophiles.
The method of preparing Chloroformate usually includes the following two kinds:
1. A common method is the reaction of chloroformic acid with trimethyl phosphite. Trimethyl Chloroformate is produced during the reaction, followed by the addition of sodium chloride for esterification to produce Chloroformate.
2. Another method for preparing Chloroformate is to react benzyl alcohol with thionyl chloride to generate benzoyl chloride. The benzoyl chloride is then reacted with sodium carbonate to form Chloroformate.
Chloroform is toxic and may be hazardous to health and the environment. Use should pay attention to protective measures, avoid contact with the skin and inhalation of its vapor. It should be properly handled during storage and disposal to avoid leakage and environmental pollution.
Last Update：2024-04-10 22:29:15