Chlorphoxim
Chlorphoxim
CAS: 14816-20-7
Molecular Formula: C12H14ClN2O3PS
Chlorphoxim - Names and Identifiers
Chlorphoxim - Physico-chemical Properties
| Molecular Formula | C12H14ClN2O3PS |
| Molar Mass | 332.74296 |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | The pure chemical product is white crystal. M. p. 65~66 ℃, vapor pressure less than 7.99 × 10-3Pa. At 20 ℃, the solubility in cyclohexanone and toluene is 40% ~ 60%, and the solubility in water is 1.7mg/L. |
| Use | Uses of organophosphorus insecticides, the mechanism of action is to inhibit cholinesterase, the structure is similar to phoxim, but the toxicity is lower than phoxim, the efficacy is greater than phoxim, the stability is better than phoxim. With stomach poisoning and contact killing effect. It has a significant effect on a variety of lepidopteran larvae and potato beetle, and is also effective for aphids, planthoppers, leaf cicadas, Panthus, red spiders, etc. Can be used for the control of storage, soil, health (Mosquito, gall bladder, etc.) pests, and the development of resistance to phoxim pests. |
Chlorphoxim - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 21 - Harmful in contact with skin |
| Safety Description | S22 - Do not breathe dust. S25 - Avoid contact with eyes. |
| UN IDs | UN 3464 6.1 / PGIII |
Chlorphoxim - Upstream Downstream Industry
| Raw Materials | Sodium Sulfuryl chloride Benzyltriethylammonium chloride Quinalphos 2-Chlorotoluene 2-Chlorobenzyl chloride 2-Chlorobenzyl cyanide 1-Butyl nitrite |
Chlorphoxim - Nature
| EPA chemical information | Chlorphoxim (14816-20-7) |
Last Update：2024-04-10 22:29:15
Chlorphoxim - Uses and synthesis methods
Toxicity
acute oral LD50>2500mg/kg in rats and acute percutaneous LD50>500mg/kg in rats.
production method
Preparation of o-chlorobenzene acetonitrile o-chlorotoluene is chlorinated with thioyl chloride to prepare o-chlorobenzyl chloride. 176.5g(1.1mol) of o-chlorobenzyl chloride, KCN98g (1.50mol), 10.9g (0.05mol) of triethylbenzyl ammonium chloride and 150mL of water were mixed, heated to 90 ℃, and stirred for 5~8h. Cooling, dewatering, washing, drying, filtering and distillation under reduced pressure, collecting 148.4-157.9g of 126-128 ℃/12-133Pa fraction with a yield of 89.4%-94.5% (B. p. 115-120 ℃/133Pa).
Preparation of sodium o-chlorophenylacetonitrile oxime 12g (0.52mol) of metal sodium was added to 250mL of absolute ethanol in batches and stirred until the metal sodium disappeared. 75.8g (0.54mol) of o-chlorobenzene acetonitrile was added. 55.6g (0.54mol) of newly prepared n-butyl nitrite were added dropwise. After dropping, stir and react at room temperature for 3h. Suction filtration, wash with ether 3 times. The dried yellow powdery solid is sodium o-chlorophenylacetonitrile oxime with a yield of 56.3g and a yield of 55.6%, m.p. 267~269 ℃.
The preparation of O,O-diethyl thiophosphoryl chloride is detailed in the preparation method of quinothion.
Synthesis of chlorothion 10.1g (0.05mol) of sodium o-chlorophenylacetonitrile oxime was suspended in 100mL of acetone, and 9.4g (0.05mol) of O,O-diethyl thiophosphoryl chloride was added dropwise under stirring. After dropping, stirring at room temperature for 2~3h, dissolving, adding water to the residue, stirring, 15.9g of white crystals were precipitated, and the yield was 96%,m.p. 64.5~65.5 ℃.
Last Update：2024-04-10 22:29:15
Chlorphoxim - Security information
| RTECS number | AL8285000 |
| customs code | 29269090 |
Last Update：2024-04-10 22:29:15
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CAS: 14816-20-7
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CAS: 14816-20-7
Tel: 18301782025
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Mobile: 18021002903
QQ: 3008007409
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Raw Materials for Chlorphoxim