Cholesterol
Cholesterol
CAS: 57-88-5
Molecular Formula: C27H46O
Cholesterol - Names and Identifiers
| Name | Cholesterol |
| Synonyms | Cholesterol Cholesterol, NF 5-Cholesten-3B-ol 5-cholesten-3β-ol 5-Cholesten-3beta-ol Cholest-5-en-3beta-ol (3β)-cholest-5-en-3-ol 5,6-Cholesten-3beta-ol 3β-hydroxycholest-5-ene cholesterol from lanolin (3beta)-cholest-5-en-3-ol 3beta-hydroxycholest-5-ene 3beta-hydroxy-5-cholestene cholesterol from hog liver (3.beta.)-Cholest-5-en-3-ol |
| CAS | 57-88-5 |
| EINECS | 200-353-2 |
| InChI | InChI=1/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1 |
| InChIKey | HVYWMOMLDIMFJA-DPAQBDIFSA-N |
Cholesterol - Physico-chemical Properties
| Molecular Formula | C27H46O |
| Molar Mass | 386.66 |
| Density | 1.06 |
| Melting Point | 148-150°C |
| Boling Point | 360 °C |
| Specific Rotation(α) | -36 º (c=2, dioxane) |
| Flash Point | 250 °C |
| Water Solubility | negligible |
| Solubility | Insoluble in water, easily soluble in ether, chloroform and other solvents. |
| Vapor Presure | 2.95E-11mmHg at 25°C |
| Appearance | White powder |
| Specific Gravity | 1.067 |
| Color | white |
| Merck | 14,2201 |
| BRN | 1915888 |
| pKa | 15.03±0.70(Predicted) |
| Storage Condition | -20°C |
| Sensitive | Sensitive to heat and air |
| Refractive Index | 1.5250 (estimate) |
| MDL | MFCD00003646 |
| Physical and Chemical Properties | Density 1.06 melting point 147-150°C boiling point 360°C flash point 250°C specific optical rotation -36 ° (c = 2, dioxane) water-soluble neglignible |
| Use | Is an important raw material for the manufacture of hormones, and can be used as emulsifiers |
Cholesterol - Risk and Safety
| Risk Codes | R10 - Flammable R48/20/22 - R40 - Limited evidence of a carcinogenic effect R38 - Irritating to the skin R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R67 - Vapors may cause drowsiness and dizziness R36/38 - Irritating to eyes and skin. R20 - Harmful by inhalation R63 - Possible risk of harm to the unborn child |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. S36/37 - Wear suitable protective clothing and gloves. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | UN 1170 3/PG 3 |
| WGK Germany | 1 |
| RTECS | FZ8400000 |
| TSCA | Yes |
| HS Code | 2906 13 10 |
| Hazard Class | IRRITANT |
| Toxicity | Present in allparts of the animal body; concentrated in spinal cord, brain, skinsecretions, and gallstones. An unsaturated, unsaponifiable alcohol(m.p. 149℃). It is synthesized in the body from ethanoate units;its metabolism is regulated by a specific set of enzymes. It is theparent compound of many other steroids and its presence in highconcentrations in the blood is suspected as being a contributoryfactor in cardiovascular disease. |
Cholesterol - Nature
Open Data Verified Data
- This product is white or light yellow needle-like crystal. Density 1. 067g/cm3, melting point 148.5 ℃, boiling point 360℃ (partial decomposition), specific rotation -31. 50(c = 2, ether). Soluble in ether, acetone, chloroform, dioxane, ethyl acetate and vegetable oil, slightly soluble in alcohol, difficult to dissolve in water. It and a water molecule to form a compound-C27 H460.H2 0 is pearlescent lobular, density 1. 03g/cm3, in 70~80 deg C into water.
- cholesterol is a major sterol in higher animals, a component of cell membrane lipids, and is mainly synthesized in the liver. The content of cholesterol in animal tissues was the most in brain tissue, liver, bone, pancreas, spleen and bile, and the heart. The content of pig brain and egg yolk was 2%. Elevated serum cholesterol levels are associated with an increased risk of cardiovascular disease. On the other hand, cholesterol is the precursor of certain important steroid substances in the body, such as steroid hormone vitamins (e. G., D3) and cholic acid. It is also an important structural component of some eukaryotic biofilms. Normally, cholesterol in the blood is maintained at a constant concentration level, and its level is significantly increased or decreased in the disease.
Last Update：2024-01-02 23:10:35
Cholesterol - Preparation Method
Open Data Verified Data
fresh animal brains and ridges were minced and dried at 40-50 ℃ to prepare dry brain powder. Dry brain powder plus 1.2 times the amount of acetone immersion, extraction 4. 5H, repeated extraction 5 times, combined extract. Acetone was recovered from the extract by distillation to obtain a yellow solid. Then, 10 times the amount of ethanol was added, and th was refluxed by heating, filtered, and the filtrate was cooled at 0 to 5 ° C., allowed to stand, precipitated crystals, and filtered to obtain crude cholesterol crystals. Add 5 times the amount of ethanol in the crude product, then add 5% ~ 6% sulfuric acid, heat reflux for 8H, remove lipid impurities, cool the hydrolysate at 0~5 ℃, precipitate crystals, filter, wash to neutrality with ethanol. The crystals were added 10 times the amount of 95% ethanol, 3% activated carbon, heated reflux decolorization th, heat preservation filtration, filtrate 0~5 deg C cooling crystallization, filtration, vacuum drying, cholesterol can be obtained.
Last Update：2022-01-01 11:14:12
Cholesterol - Standard
Authoritative Data Verified Data
This strain is derived from the extraction and purification of animal organs. This product is the bile -5 ENE -3 Lu-alcohol. Calculated as dry product, containing cholesterol (C27 H46 0) not less than 95.0%.
Last Update：2024-01-02 23:10:35
Cholesterol - Trait
Authoritative Data Verified Data
- This product is white flake crystal; Odorless.
- This product is soluble in three gas methane, soluble in ether, slightly soluble in acetone, ethyl acetate or petroleum ether, slightly soluble in ethanol, insoluble in water.
melting point
The melting point of this product (General 0612) is 147~150°C.
specific rotation
take this product, precision weighing, plus dioxane dissolution and quantitative dilution of 20mg per lm l solution, according to the law (General 0621), the specific rotation should be from one 34 ° to one 38 °.
Last Update：2022-01-01 11:24:13
Cholesterol - Use
Open Data Verified Data
artificial bezoar and hormone drugs can also be used as emulsifiers. Chemical raw materials, surfactants, cosmetics raw materials.
Last Update：2022-01-01 11:14:12
Cholesterol - Differential diagnosis
Authoritative Data Verified Data
- take about 10mg of this product, add three gas methane lm l to dissolve, add sulfuric acid lm l, three gas methane layer blood red, sulfuric acid layer to light side view should be green fluorescence.
- take about 5 m g of this product, add 2m l of three gas methane to dissolve, add 1ml of acetic anhydride, 1 drop of sulfuric acid, that is pink, quickly turn blue, and finally bright green.
- take the appropriate amount of this product and the cholesterol reference, respectively, and add acetone to make a solution containing about 2mg per lm l as the test and reference solution. According to the thin layer chromatography (General 0502) test, absorb 20pl of each of the above two solutions, respectively point on the same silica gel G thin layer plate, with ethyl acetate-toluene (1: 2) as the developing solvent, expand, take out, dry, spray with three gas methane solution of 30% three gasification of antimony, dry at 105°C for 5 minutes, immediately check, the position and color of the main spot displayed by the test solution should be the same as that of the control solution.
- The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).
Last Update：2022-01-01 11:24:14
Cholesterol - Safety
Open Data Verified Data
sealed storage.
Last Update：2022-01-01 11:14:12
Cholesterol - Exam
Authoritative Data Verified Data
acidity
take this product l.O g, put it in a plug Erlenmeyer flask, Add 10ml of ether to dissolve, and then add O .lm o l/L sodium hydroxide solution 10ml, shake for about 1 min, slowly heat to remove ether, boil for 5 min, let cool, add water 10ml, add 2 drops of phenolphthalein indicator solution under magnetic stirring, with sulfuric acid titration solution (0 .05 ol/L m) titration to pink disappeared, while doing blank test. The difference between the milliliters of sulfuric acid titrant consumed in the blank test and the milliliters of sulfuric acid titrant consumed in the sample shall not exceed 0. 3ml.
insolubles in ethanol
take 0. 5 g of this product, add 50ml ethanol, warm to dissolve, stand for 2 hours, do not produce precipitation or turbidity.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.3% (General rule 0831).
ignition residue
take l g of this product and check it according to law (General rule 0841). The remaining residue shall not exceed.
Heavy metals
The residue left under the ignition residue item shall be inspected according to law (General rule 0821, Law 2), and the heavy metal content shall not exceed 10 parts per million.
arsenic salt
take this product l.O g, add calcium hydroxide l.O g, mix, add a small amount of water to stir the loop evenly, after drying, burn with small fire to charring, then burn at 500~600°C to make it ash completely, and let it cool, add hydrochloric acid 5M l and water 23ml to dissolve, check according to law (General Principles 0822 The first law), should comply with the provisions (0.0002%).
Last Update：2022-01-01 11:24:15
Cholesterol - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system adaptability test with eighteen alkyl silane bonded silica gel as filler, with methanol as mobile phase; With evaporative light scattering detector. Precise amount of control solution (containing cholesterol per l lm 0. lmg)2CVl, injection of human liquid chromatograph, the number of theoretical plates should be not less than 5000 calculated by cholesterol peak, repeat the injection of 5 times, the relative standard deviation of cholesterol peak area should not be greater than 2 .0%.
- determination: an appropriate amount of cholesterol reference substance was accurately weighed, dissolved and quantitatively diluted with absolute ethanol respectively to prepare about 0.05mg and 0 mg cholesterol per lm l. lm g, 0. 2mg, 0. 3mg, 0. 5mg of the solution as a reference solution, the precision of each 20UL, respectively, the injection of human liquid chromatography, recording the chromatogram, with the reference solution concentration of the numerical value and the corresponding peak area of the numerical calculation of the regression equation, the correlation coefficient O) should not be less than 0.9 9; Take an appropriate amount of this product, precision weighing, dissolved and quantitatively diluted with absolute ethanol to make a solution containing about 0.125mg cholesterol per lm l, and determine with the same method, the content of cholesterol in the test article was calculated by the regression equation.
Last Update：2022-01-01 11:24:15
Cholesterol - Category
Authoritative Data Verified Data
pharmaceutical excipients, emulsifiers and soft matrix.
Last Update：2022-01-01 11:24:16
Cholesterol - Storage
Authoritative Data Verified Data
light shielding, closed storage.
Last Update：2022-01-01 11:24:16
Cholesterol - Introduction
Cholesterol is a lipid compound, belonging to the steroid group. It is a colorless, crystalline solid with a faint odor. At room temperature, Cholesterol is poorly soluble in water but easily soluble in organic solvents.
Cholesterol plays an important role in organisms. It is one of the components of cell membrane and the precursor of synthetic steroid hormones, bile acids and vitamin D. Cholesterol is particularly important for human health, but excessive intake may increase the risk of cardiovascular disease.
Cholesterol is usually obtained from animal fat or liver extraction. Methods for preparing Cholesterol include acid-base extraction, crystallization, and thin-layer chromatography.
When using Cholesterol or handling chemicals containing Cholesterol, you need to follow appropriate safety measures. Cholesterol is irritating and toxic, avoid contact with skin, eyes and respiratory tract. In the storage and handling of Cholesterol, appropriate ventilation and personal protective measures should be taken to ensure safe handling.
Cholesterol plays an important role in organisms. It is one of the components of cell membrane and the precursor of synthetic steroid hormones, bile acids and vitamin D. Cholesterol is particularly important for human health, but excessive intake may increase the risk of cardiovascular disease.
Cholesterol is usually obtained from animal fat or liver extraction. Methods for preparing Cholesterol include acid-base extraction, crystallization, and thin-layer chromatography.
When using Cholesterol or handling chemicals containing Cholesterol, you need to follow appropriate safety measures. Cholesterol is irritating and toxic, avoid contact with skin, eyes and respiratory tract. In the storage and handling of Cholesterol, appropriate ventilation and personal protective measures should be taken to ensure safe handling.
Last Update：2024-04-09 01:59:57
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