Citarinostat

Name	Citarinostat
Synonyms	HDAC-IN-2 Citarinostat ACY-241(CITARINOSTAT) Citarinostat (ACY-241) Citarinostat(ACY-241,HDAC-IN-2) 2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide 5-Pyrimidinecarboxamide, 2-[(2-chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]- 2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide
CAS	1316215-12-9

Molecular Formula	C24H26ClN5O3
Molar Mass	467.95
Density	1.293±0.06 g/cm3(Predicted)
Solubility	DMSO: ≥ 30 mg/mL
pKa	9.47±0.20(Predicted)
Storage Condition	-20℃
In vitro study	Treatment of cell lines from a variety of solid tumors with the combination of ACY-241 and paclitaxel can enhance the inhibition of cell proliferation. Compared with the single drug treatment, the combination treatment can also increase cell death, it also leads to abnormal Multipolar spindles and abnormal mitosis in dividing cells, which is associated with the formation of abnormal Multipolar spindles, induction of aneuploidy and increased cell death. In A2780 ovarian cancer cells, α-tubulin was highly acetylated and tubulin deacetylase HDAC6 was inhibited after 24 hours of 300 nM ACY-241 treatment. A low concentration of ACY-241 can selectively inhibit HDAC6, while a high concentration will result in inhibition of the class I HDAC isoenzyme.
In vivo study	In vivo, ACY-241 had better safety than other non-selective pan-HDAC inhibition. In contrast, the side effects of ACY-241 are significantly reduced because of its low efficacy against class I HDACs, but still has anti-cancer potential.

Last Update：2024-01-02 23:10:35

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Product Name: Citarinostat Request for quotation
CAS: 1316215-12-9
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Spot supply

Product Name: Citarinostat Visit Supplier Webpage Request for quotation
CAS: 1316215-12-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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Citarinostat

Citarinostat Request for Quotation