Molecular Formula | C16H22ClN3O |
Molar Mass | 307.82 |
Density | 1.212±0.06 g/cm3(Predicted) |
Melting Point | 112-115°C |
Boling Point | 514.7±50.0 °C(Predicted) |
Solubility | Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly) |
Appearance | Solid |
Color | Off-White to Yellow to Sticky |
pKa | 14.80±0.10(Predicted) |
Storage Condition | Hygroscopic, Refrigerator, under inert atmosphere |
In vivo study | Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5). |