Clomethiazolum
Clomethiazole
CAS: 533-45-9
Molecular Formula: C6H8ClNS
Clomethiazolum - Names and Identifiers
Clomethiazolum - Physico-chemical Properties
| Molecular Formula | C6H8ClNS |
| Molar Mass | 161.65 |
| Density | d425 1.233 |
| Melting Point | 127-128 °C |
| Boling Point | bp7 92° |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Appearance | Oil |
| Color | Pale Yellow |
| pKa | pKa 3.2 (Uncertain) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | 1.6000 (estimate) |
| MDL | MFCD00868012 |
| In vitro study | Clomethiazole (1 mM), in the absence of GABA, to α1/β1/γ2 or α1/β2/γ2 subunit-containing cells produced large whole-cell currents. Clomethiazole activate GABAA currents in α1/β1/γ2- and α1/β2/γ2-containing cells, with EC 50 values of 0.3 and 1.5 mM, respectively. Clomethiazole (30 μM) at low concentration also potentiates the action of GABA in both cell types, equivalent to a 3-fold increase in potency and up to 1.8-fold increase in maximal current. Clomethiazole inhibits cytochrome P450 isoforms, CYP2A6 and CYP2E1 with IC 50 values of 24 µM and 42 µM, respectively, in human liver microsomes, meanwhile all other isoforms exhibiting values > 300 µM. |
Clomethiazolum - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| biological activity | chlormethizole is a potent oral GABAA agonist. Chlormethizole can also inhibit cytochrome P450 subtypes in human liver microsomes: CYP2A6 and CYP2E1. Chlormethizole has anticonvulsant effects and has the potential to study convulsive epilepsy. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | oral-mouse LD50: 2110 mg/kg; Intraperitoneal-mouse LD50: 190 mg/kg; |
| flammability hazard characteristics | flammable, fire site releases toxic chlorides, nitrogen oxides, sulfur oxide smoke |
| storage and transportation characteristics | low temperature ventilation and drying |
| fire extinguishing agent | water, carbon dioxide, foam, sand |
Last Update：2024-04-10 22:29:15
Supplier List
Multiple SpecificationsSpot supply
Product Name: Clomethiazole Visit Supplier Webpage Request for quotationCAS: 533-45-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple SpecificationsSpot supply
Product Name: Clomethiazole Visit Supplier Webpage Request for quotationCAS: 533-45-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History