Cosmopen
Benzylpenicillin potassium
CAS: 113-98-4
Molecular Formula: C16H17KN2O4S
Cosmopen - Names and Identifiers
Cosmopen - Physico-chemical Properties
| Molecular Formula | C16H17KN2O4S |
| Molar Mass | 372.48 |
| Melting Point | 214-217 C |
| Specific Rotation(α) | D22 +285° (c = 0.748 in water) |
| Water Solubility | Soluble in water (100 mg/ml), methanol, ethanol (sparingly), and alcohol. Insoluble in chloroform. |
| Solubility | H2O: 100mg/mL |
| Appearance | Powder |
| Color | Needles from butanol (aq) |
| Merck | 14,7094 |
| BRN | 3832841 |
| PH | pH (10g/L, 25℃) : 5.0～7.5 |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Stability | Hygroscopic |
| Refractive Index | 294 ° (C=1, H2O) |
| MDL | MFCD00036193 |
| Use | Belongs to high efficiency and low toxicity antibiotics |
Cosmopen - Risk and Safety
| Risk Codes | R42/43 - May cause sensitization by inhalation and skin contact. R34 - Causes burns R11 - Highly Flammable |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S60 - This material and its container must be disposed of as hazardous waste. S37 - Wear suitable gloves. S24 - Avoid contact with skin. S22 - Do not breathe dust. |
| WGK Germany | 2 |
| RTECS | XH9700000 |
| FLUKA BRAND F CODES | 10-23 |
| TSCA | Yes |
| HS Code | 29411000 |
| Toxicity | LD50 oral in rabbit: 5848mg/kg |
Cosmopen - Upstream Downstream Industry
Cosmopen - Standard
Authoritative Data Verified Data
(25,5R,6R)-3, 3-dimethyl-6-(2-phenylacetamido)-7-oxo-4-thia-1-azabicyclo [3.2.0] heptane-2-carboxylic acid potassium salt. Calculated as dry product, including C16H17KN204S shall not be less than 96.0%.
Last Update：2024-01-02 23:10:35
Cosmopen - Trait
Authoritative Data Verified Data
- This product is a white crystalline powder; Odorless or slightly specific odor; Hygroscopicity; Rapid failure when exposed to acid, alkali or oxidant, and easy failure when placed in aqueous solution at room temperature.
- This product is easily soluble in water, slightly soluble in ethanol, insoluble in fatty oil or liquid paraffin.
Last Update：2022-01-01 13:33:02
Cosmopen - Differential diagnosis
Authoritative Data Verified Data
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 223).
- This product shows the reaction of potassium salt identification (1) (General rule 0301).
Last Update：2022-01-01 13:33:02
Cosmopen - Exam
Authoritative Data Verified Data
absorbance
take this product, precision weighing, adding water to dissolve and quantitatively dilute the solution containing 0401 mg per lml, according to UV-visible spectrophotometry (general) determination, in the wavelength of 280nm and 325nm, the absorbance should not be greater than 0.10; In the wavelength of 264nm, there is maximum absorption, absorbance should be 0.80~0.88.
visible foreign body
take 5 parts of this product, each 0.625g, plus particle inspection water dissolution, inspection according to law (General 0904), should comply with the provisions. (For aseptic dispensing)
insoluble particles
Take 3 parts of this product, and make a solution containing 50mg per lml of water for particle inspection, and check it according to law (General rule 0903). In each lg sample, particles containing 10um and more than 10um shall not exceed 6000 particles, and particles containing 25um and more than 25um shall not exceed 600 particles. (For aseptic dispensing)
crystallinity, pH, clarity and color of the solution, related substances, penicillin polymer, loss on drying, bacterial endotoxin (for injection) and sterility (for aseptic dispensing)
According to the method under the item of penicillin sodium inspection, should comply with the provisions.
Last Update：2022-01-01 13:33:03
Cosmopen - Content determination
Authoritative Data Verified Data
take this product, according to the method under the item of penicillin sodium, according to the external standard method to calculate the peak area, the result is multiplied by 1.1136, that is, the content of C16H17KN2O4S in the sample.
Last Update：2022-01-01 13:33:03
Cosmopen - Category
Authoritative Data Verified Data
B-lactam antibiotics, penicillins.
Last Update：2022-01-01 13:33:04
Cosmopen - Storage
Authoritative Data Verified Data
sealed and stored in a cool, dark and dry place.
Last Update：2022-01-01 13:33:04
Cosmopen - Penicillin potassium for injection
Authoritative Data Verified Data
This product is a crystalline sterile powder of penicillin potassium. The content of Cl6H17KN204S shall not be less than 96.0% based on the dry product; The content of C16H17KN204S shall be 95.0% ~ 115.0% of the label amount based on the average loading.
trait
This product is a white crystalline powder.
Post
take this product, according to penicillin potassium under the identification test, showed the same results.
examination
- the clarity and color of the solution should be checked according to the method under the item of penicillin sodium for injection, and should comply with the regulations.
- the content under the item of difference in loading amount of penicillin polymer shall be accurately weighed and appropriately measured according to the method of penicillin sodium and calculated by the external standard method based on penicillin peak volume, the amount of penicillin polymer should not exceed 0.10% of the labeled amount.
- weight loss on drying this product, drying at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
- insoluble particles this product is taken, and the labeled amount is added to the particle inspection water to make a solution containing 50mg per 1 ml, which is inspected according to law (General rule 0903), and the labeled amount is l. The conversion below Og is per l. In the Og sample, the particles containing l0um and 10um or more shall not exceed 6000 particles, and the particles containing 25um and 25um or more shall not exceed 600 particles.
- the pH value, related substances, bacterial endotoxin and sterility shall be checked according to the method under the item of penicillin sodium, and shall be in accordance with the regulations.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
The content under the item of loading amount difference was accurately weighed and an appropriate amount was measured according to the method of penicillin potassium. Each 1 mg of C16H17KN204S is equivalent to 1598 penicillin units.
category
with penicillin potassium.
specification
According to C16H17KN204S (1)0.l25g (200,000 units)(2)0.25g (400,000 units) (3)0.5g (800,000 units) (4)0.625g(1 million units)
storage
sealed and stored in a cool, dark and dry place.
Last Update：2022-01-01 13:33:05
Supplier List
Spot supply
Product Name: Benzylpenicillin potassium Request for quotationTel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Benzylpenicillin Potassium Salt Visit Supplier Webpage Request for quotationCAS: 113-98-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Benzylpenicillin potassium Request for quotation
CAS: 113-98-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
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Mobile: 0086 189 4982 3763
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CAS: 113-98-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
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Wechat: 0086 189 4982 3763
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Multiple SpecificationsSpot supply
Product Name: Penicillin G Potassium salt Visit Supplier Webpage Request for quotationCAS: 113-98-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Benzylpenicillin potassium Request for quotationTel: +86-17551318830
Email: r@reformchem.com
Mobile: +86-17551318830
QQ: 3787852685
Spot supply
Product Name: Benzylpenicillin Potassium Salt Visit Supplier Webpage Request for quotationCAS: 113-98-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Benzylpenicillin potassium Request for quotation
CAS: 113-98-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 113-98-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Multiple SpecificationsSpot supply
Product Name: Penicillin G Potassium salt Visit Supplier Webpage Request for quotationCAS: 113-98-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for Cosmopen
Downstream Products for Cosmopen