Crisaborole-004
4-(4-Bromo-3-formyl-phenoxy)-benzonitrile
CAS: 906673-54-9
Molecular Formula: C14H8BrNO2
Crisaborole-004 - Names and Identifiers
Crisaborole-004 - Physico-chemical Properties
| Molecular Formula | C14H8BrNO2 |
| Molar Mass | 302.12 |
| Density | 1.56±0.1 g/cm3(Predicted) |
| Melting Point | 109-111°C |
| Boling Point | 441.9±35.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Appearance | Solid |
| Color | White to Light Yellow |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
Crisaborole-004 - Reference Information
| Use | 4-(4-bromo-3-formylphenoxy) benzonitrile is a clerioborro intermediate, clenbuterol is a non-hormonal drug, which has the advantages of convenient use, small adverse reactions, low recurrence rate and high clinical application value. |
| preparation | (1) preparation of 4-(3-(formyl) phenoxy) benzonitrile 122g(1mol) M-hydroxybenzaldehyde, 110 ml DMF, potassium carbonate 276g(2mol) were added to the reaction kettle, P-fluorobenzonitrile 182g(2mol) was added under stirring, reaction was carried out at ℃ for 16h, cooling, adding water, extracting with ethyl acetate for three times, recovery of ethyl acetate, methanol slurry, filtration, drying to give Brown solid 203G, yield 91%;(2) 4-(4-bromo-3-formylphenoxy) benzonitrile preparation 223G (1mol)4-(3-(formyl) phenoxy) benzonitrile, 17.2 ml of acetonitrile, 0.1g(1.1mol) of p-toluenesulfonic acid was added to the reaction kettle at 25 °c, and 196g (mol)NBS was added to the reaction kettle in batches, and refluxed for 6h, acetonitrile was recovered, water was added, filtration, methanol pulping, and drying to give a white solid of 245g, with a yield of 81%. |
Last Update：2024-04-09 21:00:56
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QQ: 2853786052
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Product Name: 4-(4-Bromo-3-formylphenoxy)benzonitrile Visit Supplier Webpage Request for quotation
CAS: 906673-54-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 906673-54-9
Tel: 18301782025
Email: 3008007409@qq.com
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