D-(3,4,5-TRIFLUOROPHENYL)-ALANINE

D-(3,4,5-TRIFLUOROPHENYL)-ALANINE - Names and Identifiers

Name	D-2-Amino-3-(3,4,5-trifluoro-phenyl)alanine
Synonyms	H-D-PHE(F)3-OH H-D-PHE(M,P-F3)-OH H-D-PHE(3,4,5-F 3)-OH H-D-PHE(3,4,5-TRIFLUORO)-OH 3,4,5-TRIFLUORO-D-PHENYLALANINE D-(3,4,5-TRIFLUOROPHENYL)-ALANINE D-2-Amino-3-(3,4,5-trifluoro-phenyl)alanine (R)-2-amino-3-(3,4,5-trifluorophenyl)propanoic acid (R)-2-AMINO-3-(3,4,5-TRIFLUORO-PHENYL)-PROPIONIC ACID
CAS	1217684-62-2

D-(3,4,5-TRIFLUOROPHENYL)-ALANINE - Physico-chemical Properties

Molecular Formula	C9H8F3NO2
Molar Mass	219.16
Storage Condition	Store at -15°C

D-(3,4,5-TRIFLUOROPHENYL)-ALANINE - Introduction

D-2-Amino-3-(3,4,5-trifluoro-phenyl)alanine (D-2-Amino-3-(3,4,5-trifluoro-phenyl)alanine) is an organic compound with the following properties:

1. Appearance: white crystalline powder.
2. Solubility: Soluble in water and organic solvents such as alcohols and ketones.
3. chemical properties: as a derivative of amino acid, it has amino and carboxyl functional groups and can participate in a variety of reactions, such as acylation, amination and esterification.

The application of D-2-Amino-3-(3,4,5-trifluoro-phenyl)alanine is as follows:

1. Pharmaceutical field: It is widely used in the synthesis of enantioselective products in drugs, especially for the synthesis of chiral drugs. It plays an important role in the structure of certain drugs, such as antiviral drugs and cancer treatment drugs.
2. Research purposes: As a kind of chiral amino acid, it can be used as an important reagent for the study of synthesis of chiral compounds and biologically active molecules.

Regarding the preparation method, the D-2-Amino-3-(3,4,5-trifluoro-phenyl)alanine can be synthesized by the following steps:

1. first synthesis of 3,4,5-trifluorobenzoic acid: by benzoic acid and fluoride (such as boron trifluoride) reaction to obtain the corresponding fluorinated product, and then the fluorinated product with alkali reaction, generating 3,4,5-trifluorobenzoic acid.
2. re-synthesis of D-2-Amino-3-(3,4,5-trifluoro-phenyl)alanine: 3,4, 5-trifluorobenzoic acid is reacted with existing L-2-bromopropionate to generate D-2-Amino-3-(3,4,5-trifluoro-phenyl)alanine.

Regarding safety information, D-2-Amino-3-(3,4,5-trifluoro-phenyl)alanine should be stored in sealed containers and placed in a dry, cool and well-ventilated place. During use, appropriate protective equipment, such as chemical protective gloves, goggles, and laboratory coats, should be worn to avoid inhalation, contact with skin, or entry into the digestive tract. Be careful during operation to avoid dust and splashing solution. In case of accidental entry into eyes or inhalation, rinse immediately with plenty of water and seek medical attention.

Last Update：2024-04-09 21:54:55