D-3-Trifluoromethylphe
D-3-Trifluoromethylphe
CAS: 14464-67-6
Molecular Formula: C10H10F3NO2
D-3-Trifluoromethylphe - Names and Identifiers
| Name | D-3-Trifluoromethylphe |
| Synonyms | H-D-PHE(M-CF3)-OH H-D-PHE(3-CF 3)-OH RARECHEM BK PT 0136 D-3-Trifluoromethylphe D-3-TRIFLUOROMETHYLPHE H-D-PHE(3-TRIFLUOROMETHYL)-OH D-3-Trifluoromethylphenylalanine D-3-TRIFLUOROMETHYLPHENYLALANINE 3-Trifluoromethyl-D-phenylalanine 3-TRIFLUOROMETHYL-D-PHENYLALANINE 3-(trifluoromethyl)-L-phenylalanine (2R)-2-ammonio-3-[3-(trifluoromethyl)phenyl]propanoate (R)-2-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID |
| CAS | 14464-67-6 |
| InChI | InChI=1/C10H10F3NO2/c11-10(12,13)7-3-1-2-6(4-7)5-8(14)9(15)16/h1-4,8H,5,14H2,(H,15,16)/t8-/m1/s1 |
D-3-Trifluoromethylphe - Physico-chemical Properties
| Molecular Formula | C10H10F3NO2 |
| Molar Mass | 233.19 |
| Density | 1.364±0.06 g/cm3(Predicted) |
| Boling Point | 301.2±42.0 °C(Predicted) |
| Flash Point | 135.9°C |
| Vapor Presure | 0.000475mmHg at 25°C |
| Appearance | White powder |
| pKa | 2.16±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.502 |
| MDL | MFCD01860875 |
D-3-Trifluoromethylphe - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
D-3-Trifluoromethylphe - Introduction
D-3-Trifluoromethylphe is an organic compound with the formula C9H9F3NO2. The following is a description of its nature, use, formulation and safety information:
Nature:
1. Appearance: Colorless crystalline solid.
2. Melting point: About 180-185 ° C.
3. Solubility: almost insoluble in water, soluble in ethanol, chloroform and other organic solvents.
4. Optical Activity: It is a D-isomer and has optical activity.
Use:
1. Pharmaceutical field: in pharmaceutical research, D-3-Trifluoromethylphe is often used as an intermediate for the synthesis of drugs.
2.3-(trifluoromethyl)-D-phenylpropionyl chloride can be prepared by reaction with acetyl chloride, which can be further used in organic synthesis.
Method:
The preparation of D-3-Trifluoromethylphe can be achieved through the following steps:
1. Diazotization of benzoic acid to obtain benzodiazoformic acid.
2. Benzenediazoformic acid and hydrochloric acid are reacted to obtain benzodiazoformate.
3. Benzenediazoformate is reduced to give 3-amino-D-phenyl acrylic acid.
4.3-amino-D-phenyl acrylic acid is reacted with trifluoromethyl O-phenyl dithione to give D-3-Trifluoromethylphe.
Safety Information:
With regard to D-3-Trifluoromethylphe safety information, it is necessary to strictly follow relevant safety procedures and personal protective measures when operating in laboratories and pharmaceutical facilities. The specific toxicity and danger of this compound has not been reported and therefore requires adequate evaluation and careful handling. At the same time, avoid contact with skin, eyes and respiratory tract. If contact is not careful, rinse with plenty of water immediately and seek medical attention. Always store it in a closed container resistant to organic solvents, away from ignition and organic matter.
Nature:
1. Appearance: Colorless crystalline solid.
2. Melting point: About 180-185 ° C.
3. Solubility: almost insoluble in water, soluble in ethanol, chloroform and other organic solvents.
4. Optical Activity: It is a D-isomer and has optical activity.
Use:
1. Pharmaceutical field: in pharmaceutical research, D-3-Trifluoromethylphe is often used as an intermediate for the synthesis of drugs.
2.3-(trifluoromethyl)-D-phenylpropionyl chloride can be prepared by reaction with acetyl chloride, which can be further used in organic synthesis.
Method:
The preparation of D-3-Trifluoromethylphe can be achieved through the following steps:
1. Diazotization of benzoic acid to obtain benzodiazoformic acid.
2. Benzenediazoformic acid and hydrochloric acid are reacted to obtain benzodiazoformate.
3. Benzenediazoformate is reduced to give 3-amino-D-phenyl acrylic acid.
4.3-amino-D-phenyl acrylic acid is reacted with trifluoromethyl O-phenyl dithione to give D-3-Trifluoromethylphe.
Safety Information:
With regard to D-3-Trifluoromethylphe safety information, it is necessary to strictly follow relevant safety procedures and personal protective measures when operating in laboratories and pharmaceutical facilities. The specific toxicity and danger of this compound has not been reported and therefore requires adequate evaluation and careful handling. At the same time, avoid contact with skin, eyes and respiratory tract. If contact is not careful, rinse with plenty of water immediately and seek medical attention. Always store it in a closed container resistant to organic solvents, away from ignition and organic matter.
Last Update：2024-04-09 21:54:55
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View History
D-3-Trifluoromethylphe
2-(7-methoxy-3,4-dihydronaphthalen-1-yl)ethan-1-amine
1-aza-2-methoxy-1-cycloheptene
773092-05-0
磷酸二苯酯
Z-dl-norvaline
170899-08-8
4-phenylmorpholin-3-one
Galanthamine
TERT
2-(7-methoxy-3,4-dihydronaphthalen-1-yl)ethan-1-amine
1-aza-2-methoxy-1-cycloheptene
773092-05-0
磷酸二苯酯
Z-dl-norvaline
170899-08-8
4-phenylmorpholin-3-one
Galanthamine
TERT