D-4-Chlorophenylalanine
D-4-chlorophenylalanine
CAS: 14091-08-8
Molecular Formula: C9H10ClNO2
D-4-Chlorophenylalanine - Names and Identifiers
| Name | D-4-chlorophenylalanine |
| Synonyms | D-4-Chlorophe Phe(4'-Cl),HCl H-p-Chloro-D-Phe-OH RARECHEM BK PT 0016 H-D-Phe(4-Cl)-OH·HCl D-4-Chlorophenylalanine D-4-chlorophenylalanine P-CHLORO-D-PHENYLALANINE 4-chloro-D-phenylalanine D-4-Chlorophenylalanine HCl P-CHLORO-D-PHENYLALANINE HCL (2R)-2-amino-3-(4-chlorophenyl)propanoic acid (2S)-2-amino-3-(4-chlorophenyl)propanoic acid (R)-2-AMINO-3-(4-CHLORO-PHENYL)-PROPIONIC ACID (R)-2-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID HYDROCHLORIDE |
| CAS | 14091-08-8 |
| InChI | InChI:1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13) |
D-4-Chlorophenylalanine - Physico-chemical Properties
| Molecular Formula | C9H10ClNO2 |
| Molar Mass | 199.63 |
| Density | 1.336±0.06 g/cm3(Predicted) |
| Melting Point | 260℃ |
| Boling Point | 339.5±32.0 °C(Predicted) |
| Flash Point | 176.6°C |
| Water Solubility | Slightly soluble in water. |
| Vapor Presure | 4.46E-06mmHg at 25°C |
| Appearance | White powder |
| pKa | 2.18±0.10(Predicted) |
| Storage Condition | −20°C |
| MDL | MFCD00079675 |
D-4-Chlorophenylalanine - Risk and Safety
| Risk Codes | R25 - Toxic if swallowed R43 - May cause sensitization by skin contact |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| Hazard Class | 6.1 |
D-4-Chlorophenylalanine - Reference
| Reference Show more | 1. [IF=6.529] Ying-Jie Dong et al."Soporific effect of modified Suanzaoren Decoction on mice models of insomnia by regulating Orexin-A and HPA axis homeostasis."Biomed Pharmacother. 2021 Nov;143:112141 |
D-4-Chlorophenylalanine - Introduction
Nature:
p-Chloro-L-phenylalanine is a chiral compound with two stereoisomers, denoted L-and D-, respectively-. The commonly used p-chloro-L-phenylalanine is the L-isomer. It is a solid that is soluble in ethanol and a small amount of water. P-chloro-L-phenylalanine is an optically active compound, and its optical rotation can be measured with a polarimeter.
Use:
p-Chloro-L-phenylalanine is widely used in the field of medicine and is commonly used as an intermediate for some synthetic drugs. It can be used for the synthesis of p-chloro-L-phenylpropanol, p-chloro-L-phenylalanine and peptides and other compounds. In addition, p-chloro-L-phenylalanine can also be used as a stereoselective catalyst.
Preparation Method:
There are various methods for preparing p-chloro-L-phenylalanine. The common method is by the reaction of p-chlorophenylacetyl chloride and aminopropionic acid. Specific steps involve chlorination, hydrolysis, separation and crystallization.
Safety Information:
The toxicity of chlorine-L-phenylalanine is low, but it is still necessary to pay attention to safe operation. During the operation, care should be taken to avoid contact with the skin and inhalation of its dust. At the same time, contact with strong oxidizing and reducing agents should be avoided to prevent dangerous reactions. Keep away from open flames and high temperatures during storage and transportation. If there is inadvertent contact or misuse, should be promptly washed or seek medical help. In order to ensure safety, please read the safety data form of relevant chemicals carefully before operation.
Last Update：2024-04-09 21:11:58
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