D-Fructose-1,6-Diphosphate
D-Fructose-1,6-Diphosphate
CAS: 488-69-7
Molecular Formula: C6H14O12P2
D-Fructose-1,6-Diphosphate - Names and Identifiers
| Name | D-Fructose-1,6-Diphosphate |
| Synonyms | CPC 111 F1,6diP Fosfructose fructose diphosphate fructose-1,6-biphosphate fructose-1,6-bisphosphate Hexose diphosphate hydrate D-Fructose-1,6-Diphosphate D-Fructose 1,6-bisphosphate D-fructose 1,6-bisphosphate 1,6-di-O-phosphono-D-fructose Fructose 1,6-diphosphate sodium D-Fructose 1,6-bisphosphoric acid 1,6-di-O-phosphonohex-2-ulofuranose 1,6-di-O-phosphono-D-fructofuranose beta-D-fructofuranose-1,6-diphosphate 1,6-di-O-phosphono-beta-D-fructofuranose 2,5-anhydro-1,6-di-O-phosphono-D-glucitol d-[3-13C]fructose 1,6-bisphosphate(sodiuM salt) |
| CAS | 488-69-7 |
| EINECS | 207-683-6 |
| InChI | InChI=1/C6H14O11P2/c7-5-3(1-15-18(9,10)11)17-4(6(5)8)2-16-19(12,13)14/h3-8H,1-2H2,(H2,9,10,11)(H2,12,13,14)/t3-,4+,5-,6-/m1/s1 |
D-Fructose-1,6-Diphosphate - Physico-chemical Properties
| Molecular Formula | C6H14O12P2 |
| Molar Mass | 340.12 |
| Density | 2.007±0.06 g/cm3(Predicted) |
| Melting Point | 72--74°C |
| Boling Point | 819.8±75.0 °C(Predicted) |
| Flash Point | 380.3°C |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Vapor Presure | 5.52E-23mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 1?+-.0.10(Predicted) |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.585 |
| Use | Cardiovascular system drugs |
D-Fructose-1,6-Diphosphate - Risk and Safety
| UN IDs | 1759 |
| Hazard Class | 8 |
| Packing Group | III |
D-Fructose-1,6-Diphosphate - Reference
| Reference Show more | 1. Xiaonan Wang, Ying Liu, Juan Zhang, Genxi Li, Oxime chemistry-mediated covalent capturing on electrode surface with guanidinium recognition and application for aldolase activity assay, Sensors and Actuators B: Chemical, Volume 242, 2017, Pages 687-693, ISS |
D-Fructose-1,6-Diphosphate - Nature
Open Data Verified Data
- This product is white or white crystalline powder, easy to flow, easy to absorb moisture. Soluble in water. Slightly fragrant, slightly salty, dry product stable at room temperature.
- This product is an intermediate product of glucose metabolism in human body. It regulates the activity of several enzymes in glucose metabolism and increases the concentration of adenosine triphosphate and creatine phosphate in cells, promote the influx of potassium ions, increase the content of diphosphoglyceric acid in red blood cells, inhibit the release of oxygen free radicals and histamine, and reduce the tissue damage caused by ischemia and hypoxia, in particular, it shows a good protective effect on ischemic myocardium. Intravenous injection, plasma half-life of 10~15 min. It is distributed from the blood to the blood circulation outside the organization, by the phosphatase hydrolysis into phosphoric acid and fructose, very little part of the urine from the discharge.
Last Update：2024-01-02 23:10:35
D-Fructose-1,6-Diphosphate - Preparation Method
Open Data Verified Data
- enzymatic conversion of free yeast cells.
- enzymatic conversion of immobilized yeast cells.
Last Update：2022-01-01 11:13:27
D-Fructose-1,6-Diphosphate - Use
Open Data Verified Data
- it is suitable for the adjuvant treatment of myocardial ischemia.
- usage and dose of intravenous infusion, once lOg. Immediately before use, lOOmL of water for injection was dissolved and then instilled twice daily at a rate of 10 ml per minute. Also applicable to metabolic disorders, malnutrition, severe burns and intravenous nutrition infusion associated with hypophosphatemia, due to
- 2,3-= glycerol phosphate deficiency due to intravenous rehydration, as well as cardiac surgery in patients undergoing cardiopulmonary bypass.
Last Update：2022-01-01 11:13:27
D-Fructose-1,6-Diphosphate - Safety
Open Data Verified Data
-
li may have mild reactions such as numbness of lips, pain at injection site, occasional dizziness, chest tightness and allergic reaction. Allergic to this product, hyperphosphatemia and severe renal insufficiency disabled. This product can not be dissolved in other drugs, especially with alkaline solution, calcium salt mixed use.
- sealed and kept in a cool place.
Last Update：2022-01-01 11:13:28
D-Fructose-1,6-Diphosphate - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| efficacy and action | fructose diphosphate sodium (1,6 fructose diphosphate, FDP), as an important intermediate product of intracellular glucose metabolism, has the function of regulating several enzyme activities in glucose metabolism, and is a molecular level drug to restore and improve cell metabolism. it is clinically used to treat coronary heart disease, angina pectoris, myocardial infarction, cerebral infarction and shock to achieve satisfactory results. In recent years, the clinical application of this drug in the treatment of other diseases has made new progress, and its application is becoming more and more extensive. |
| biological activity | Fosfructose (Diphosphofructose) is a cell-protective natural sugar phosphate with potential for cardiovascular ischemia, sickle cell anemia and asthma research. Fosfructose works by stimulating anaerobic glycolysis, which produces adenosine triphosphate under ischemic conditions. |
| use | cardiovascular system medication. |
Last Update：2024-04-09 20:52:54
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