Name | D(-)-Penicillamine |
Synonyms | H-D-Pen-OH Penicilllamine D-Penicillamine D(-)-Penicillamine D-(-)-Penicillamine N,N-dimethylcysteine 3,3-Dimethyl-D(-)-cysteine D-minus-penicillamine free base 3,3-Dimethyl-D-cysteine~3-Mercapto-D-valine |
CAS | 52-67-5 |
EINECS | 200-148-8 |
InChI | InChI=1/C5H11NO2S/c1-6(2)4(3-9)5(7)8/h4,9H,3H2,1-2H3,(H,7,8) |
InChIKey | VVNCNSJFMMFHPL-VKHMYHEASA-N |
Molecular Formula | C5H11NO2S |
Molar Mass | 149.21 |
Density | 1.171g/cm3 |
Melting Point | 212℃ |
Boling Point | 231.297°C at 760 mmHg |
Flash Point | 93.686°C |
Water Solubility | 11.1 g/100 mL (20℃) |
Vapor Presure | 0.022mmHg at 25°C |
Appearance | Form Powder, color White to almost white |
pKa | pKa 7.83±0.01(H2O,t =37±0.05,I=0.15)(Approximate) |
Storage Condition | 2-8°C |
Stability | Stable. Incompatible with strong oxidizing agents. |
Refractive Index | 1.514 |
MDL | MFCD00064302 |
Physical and Chemical Properties | Chemical Properties White Fine Grain Powder. Melting point 198.5 ℃. Soluble in water, slightly soluble in ethanol, insoluble in ether or chloroform. It has a special smell and bitter taste. |
Use | Antidote, used for heavy metal ion poisoning, also used for rheumatoid arthritis and chronic active hepatitis and other immune diseases |
Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
Safety Description | S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 2 |
RTECS | YV9425000 |
HS Code | 29309016 |
Toxicity | LD50 in rats (mg/kg): >10000 orally, >660 i.p. (Jaffe) |
This product is D-3-mercaptovaline, calculated as dry product, containing C5H11N02S not less than 95.0%.
take this product, precision weighing, plus lmol/L sodium hydroxide solution dissolved and quantitatively diluted to make a solution containing about 50mg per lml, determined according to law (General 0621), the specific rotation is from one to 61.0 ° to one to 65.0 °.
take this product, add water to make a solution containing 10 mg per lml, according to the law (General 0631), the pH value should be 4.0~6.0.
take about 0.125g of this product, weigh it accurately, put it in a 100ml measuring flask, and add diluent (take ethylenediamine tetraacetic acid disodium l.Og, add water to dissolve and dilute into 1000ml, shake well) dissolve and dilute to the scale, shake well, as a test solution; additionally, an appropriate amount of penicillamine disulfide reference substance dried at 105°C to constant weight was precisely weighed, dissolved and quantitatively diluted with the above diluent to prepare a solution containing about 12.5ug per 1 ml as the reference solution; take appropriate amounts of penicillamine control and penicillamine disulfide control, and add the above diluent to dissolve and dilute to prepare penicillamine 1 mg and penicillamine disulfide per 1 ml. A solution of 1 mg was used as the system suitability solution. According to the determination by high performance liquid chromatography (General rule 0512), silica gel was bonded with eighteen alkyl silane as filler; Sodium hexanesulfonate phosphate solution [take sodium dihydrogen phosphate 0.2g and sodium hexanesulfonate g, add water to dissolve, adjust the pH value to 3.0±0.1 with phosphoric acid solution (1-10), dilute to 1000ml with water, mix well] as mobile phase; The detection wavelength is 210mn, take the system applicable solution 20u1 and inject it into human liquid chromatograph, record the chromatogram, the resolution between penicillamine peak and penicillamine disulfide peak should be greater than 3.0. The sample solution and the reference solution were respectively injected with 20ul, and the chromatogram was recorded. Calculated by peak area according to external standard method, containing penicillamine disulfide shall not exceed 1.0%.
take this product, with phosphorus pentoxide as desiccant, at 60°C under reduced pressure drying to constant weight, weight loss should not exceed 0.5% (General rule 0831).
take this product about 0.15g, precision weighing, add acetate buffer (take sodium acetate 5.4g, put 100ml measuring flask, add water 50ml to dissolve, adjust pH value to 4.6 with glacial acetic acid, add water to dilute to the scale, Shake) 100ml to dissolve and dilute to the scale, according to the potentiometric titration method (General 0701), with platinum electrode as the indicator electrode, Mercury-sulfuric acid mercury electrode as the reference electrode, slowly titrate to the end point with mercury nitrate titration solution (0.05mol/L). Each 1 ml of mercury nitrate titration solution (0.05mol/L) is equivalent to 7.461mg of C5H11NO2S.
Heavy metal antidote.
sealed storage.
This product contains penicillamine (C5H11N02S) should be 90.0% to 110.0% of the label.
This product is sugar-coated tablets, White after removing the coating.
take this product, remove the coating, grind, weigh an appropriate amount (about 0.25g equivalent to penicillamine), add 25ml of water, stir to dissolve, filter, the filtrate showed the same results according to the tests of (1) and (2) under the item of penicillamine.
Take 10 tablets of this product, precision weighing, fine grinding, precision weighing to take an appropriate amount (about 0.15g equivalent to penicillamine), according to the method of penicillamine under the item, then get.
Same as penicillamine.
0.125g
sealed storage.