D-SERINE
D-SERINE
CAS: 312-84-5
Molecular Formula: C3H7NO3
D-SERINE - Names and Identifiers
| Name | D-SERINE |
| Synonyms | D-Ser D-Serin D-SERINE D-Ser-OH H-D-Ser-OH D-(+)-Serine β-Hydroxyalanine D-2-Amino-3-Hydroxypropionic D-2-Amino-3-hydroxypropanoic acid (R)-2-AMINO-3-HYDROXYPROPIONIC ACID (R)-2-amino-3-hydroxypropanoic acid (2R)-2-amino-3-hydroxy-propanoic acid |
| CAS | 312-84-5 |
| EINECS | 206-229-4 |
| InChI | InChI=1/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1 |
| InChIKey | MTCFGRXMJLQNBG-UWTATZPHSA-N |
D-SERINE - Physico-chemical Properties
| Molecular Formula | C3H7NO3 |
| Molar Mass | 105.09 |
| Density | 1.3895 (rough estimate) |
| Melting Point | 220 °C |
| Boling Point | 197.09°C (rough estimate) |
| Specific Rotation(α) | -14.75 º (c=10 2 N HCl) |
| Water Solubility | 346 g/L (20 ºC) |
| Solubility | H2O: 0.1g/mL, clear, colorless |
| Appearance | White powder |
| Color | White |
| Merck | 14,8460 |
| BRN | 1721403 |
| pKa | 2.16±0.10(Predicted) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| Refractive Index | 1.4368 (estimate) |
| MDL | MFCD00004269 |
| Physical and Chemical Properties | Synthetic 25-peptide corticotropin analogs. The effect is 6 times stronger than that of natural corticotropin and cortical 24 peptide, and the maintenance time is longer, and the intravenous injection can last for 8H. |
| Use | Used as pharmaceutical intermediates, biochemical reagents |
D-SERINE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | VT8200000 |
| TSCA | Yes |
| HS Code | 29225000 |
D-SERINE - Reference
| Reference Show more | 1. [IF=7.1] Haiyan Fu et al."Rational design of an “on-off-on” fluorescent assay for chiral amino acids based on quantum dots and nanoporphyrin."Sensor Actuat B-Chem. 2019 May;287:1 2. [IF=7.79] Ye Lu et al."Enhancing hydrogel-based long-lasting chemiluminescence by a platinum-metal organic framework and its application in array detection of pesticides and D-amino acids."Nanoscale. 2020 Feb;12(8):4959-4967 3. [IF=6.057] Haizhi Zhang et al."Colorimetric quantification of sodium benzoate in food by using d-amino acid oxidase and 2D metal organic framework nanosheets mediated cascade enzyme reactions."Talanta. 2022 Jan;237:122906 4. [IF=3.24] Zhichen Cai et al."Metabolomics characterizes the metabolic changes of Lonicerae Japonicae Flos under different salt stresses."Plos One. 2020 Dec;15(12):e0243111 |
D-SERINE - Standard
Authoritative Data Verified Data
This product is L-2-amino -3-hydroxypropionic acid. Calculated as dried product, the content of C3H7N03 shall not be less than 98.5%.
Last Update：2024-01-02 23:10:35
D-SERINE - Trait
Authoritative Data Verified Data
- This product is white crystal or crystalline powder; Odorless.
- This product is soluble in water, almost insoluble in ethanol, acetone or ethanol.
specific rotation
take this product, precision weighing, plus 2mol / L hydrochloric acid solution dissolved and quantitative dilution made in each lml containing about 0.1g of the solution was measured according to the law (General rule 0621), and the specific rotation was 14.0 ° to 15.6 °.
Last Update：2022-01-01 11:43:14
D-SERINE - Introduction
Solubility in water: 346G/L (20°C), insoluble in ethanol, ether and benzene; Insoluble in organic solvents.
Last Update：2022-10-16 17:24:30
D-SERINE - Differential diagnosis
Authoritative Data Verified Data
- appropriate amounts of this product and the serine reference product were dissolved and diluted with water to prepare a solution containing about 0.4mg per 1 ml as the test solution and the reference solution. According to the chromatographic condition test under other amino acids, the position and color of the main spot of the test solution should be the same as that of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 917).
Last Update：2022-01-01 11:43:15
D-SERINE - Exam
Authoritative Data Verified Data
acidity
take 0.30g of this product, add 30ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 5.5~6.5.
transmittance of solution
take l.Og of this product, add water 20ml to dissolve, according to ultraviolet-visible spectrophotometry (General rule 0401), determine the transmittance at the wavelength of 430mn, not less than 98.0%.
chloride
take 0.25g of this product and check it according to law (General rule 0801). Compared with the control solution made of 5.0 ml of standard sodium chloride solution, it should not be more concentrated (0.02%).
sulfate
take l.Og of this product and check it according to law (General rule 0802). Compared with the control solution made of 2.0 ml of standard potassium sulfate solution, it should not be more concentrated (0.02%).
ammonium salt
take 0.10g of this product and check it according to law (General rule 0808). Compared with the control solution made of 2.0 ml of standard ammonium chloride solution, it shall not be deeper (0.02%).
other amino acids
take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 20mg per lml as a test solution; Take 1ml for precision measurement and put it in a 200ml measuring flask, dilute to the scale with water, shake well, as a control solution; Take the appropriate amount of serine reference and methionine reference respectively, and place in the same measuring flask, water was added to dissolve and diluted to prepare a solution containing about 0.4mg each per 1ml as a system-suitable solution. According to the thin layer chromatography (General 0502) test, absorb the above three solutions each 5 u1, respectively, on the same silica gel G thin layer plate, with n-butanol-water-glacial acetic acid (3:1:1) for development, after deployment, air-drying, spraying with ninhydrin in acetone solution (1-50), heating at 80°C until spots appear, and examination immediately. The control solution should show a clear spot, and the system applicable solution should show two completely separated spots. If the test solution shows impurity spots, the color should not be deeper (0.5%) than the main spot of the control solution.
loss on drying
take this product, dry at 105°C for 3 hours, loss of weight shall not exceed 0.2% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Iron Salt
take l.Og of this product and check it according to law (General rule 0807). Compared with the control solution made of 0.001% of standard iron solution, it shall not be deeper ().
Heavy metals
Take 2.G of this product, add 23ml of water to dissolve, add 2ml of acetate buffer (pH3.5), and check according to law (the first law of the general rules 0821), containing heavy metals shall not exceed 10 parts per million.
arsenic salt
take this product 2. G, add water 23ml dissolved, add hydrochloric acid 5ml, according to the law inspection (General Principles 0822 first law), should comply with the provisions (0.0001%).
bacterial endotoxin
take this product, check according to law (General 1143), the amount of endotoxin in each lg serine should be less than 12EU. (For injection)
Last Update：2022-01-01 11:43:16
D-SERINE - Content determination
Authoritative Data Verified Data
take this product about O.lg, precision weighing, add anhydrous formic acid 1 ml to dissolve, add glacial acetic acid 25ml, according to the potentiometric titration method (General 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 10.51mg of C3H7N03.
Last Update：2022-01-01 11:43:17
D-SERINE - Category
Authoritative Data Verified Data
amino acid drugs.
Last Update：2022-01-01 11:43:17
D-SERINE - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:43:17
D-SERINE - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Biological activity | (R)-Serine is the R-enantiomer of serine. Serine is used in protein biosynthesis. |
| use | is effective for inflammatory patients such as temporal arteritis and multiple rheumatism. It is used for biochemical research, preparation of tissue culture medium, and used as amino acid nutrition medicine in medicine. Used as a pharmaceutical intermediate, biochemical reagent |
| production method | DL-serine and chloroacetyl chloride are used as raw materials under alkaline conditions, evaporated to dry under reduced pressure, extracted with ethyl acetate, and the product is obtained after treatment with activated carbon and resolution with acylase I. |
Last Update：2024-04-09 19:05:11
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