D-SPHINGOSINE
D-SPHINGOSINE
CAS: 123-78-4
Molecular Formula: C18H37NO2
D-SPHINGOSINE - Names and Identifiers
| Name | D-SPHINGOSINE |
| Synonyms | SPHINGOSINE D-SPHINGOSINE BRAIN, BOVINE BRAIN SPHINGOSINE SPHINGOSINE, D-ERYTHRO SPHINGOSINE, C18 CHAIN TRANS D-THREO-SPHINGOSINE TRANS D-ERYTHRO-SPHINGOSINE TRANS-D-ERYTHRO-2-AMINO-4-OCTADECENE-1,3-DIOL |
| CAS | 123-78-4 |
| EINECS | 204-651-3 |
| InChIKey | WWUZIQQURGPMPG-KRWOKUGFSA-N |
D-SPHINGOSINE - Physico-chemical Properties
| Molecular Formula | C18H37NO2 |
| Molar Mass | 299.492 |
| Density | 0.9758 (rough estimate) |
| Melting Point | 74.2-78.1 °C |
| Boling Point | 440.8°C (rough estimate) |
| Water Solubility | chloroform: 20 mg/mL, clear, colorless to very faintly yellow |
| Appearance | Form Powder or Waxy Solid Color White to cream |
| Storage Condition | -20°C |
| Stability | Stable. Incompatible with strong acids, strong bases, strong oxidizing agents. |
| Refractive Index | 1.5000 (estimate) |
| MDL | MFCD00036751 |
D-SPHINGOSINE - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 1-8-10 |
| HS Code | 29221985 |
D-SPHINGOSINE - Biological activity
sphingosine, Sphingosine (2-amino-4-trans-octadecene-1,3-diol, C18 Sphingosine), is an amino alcohol with 18 carbon atoms of unsaturated hydrocarbon chain. it forms the main part of sphingolipids. sphingolipids are a kind of cell membrane lipids, including sphingomyelin, an important phospholipid.
Last Update：2024-04-10 22:29:15
D-SPHINGOSINE - Target
p32
8 μM (EC 50 )
PKC
PP2A
Human Endogenous Metabolite
Last Update：2024-04-10 22:29:15
D-SPHINGOSINE - In vitro study
A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines. D-erythro-Sphingosine inhibits protein kinase C in vitro. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells.
Last Update：2024-04-10 22:40:09
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