Name | D-Xylose |
Synonyms | D-XYL D-Xylose FEMA 3606 D-XYLOSE JP6 NISTC31178708 D-XYLOPYRANOSE D-XYLOSE USP23 D-(+)-WOOD SUGAR alpha-D-Xylopyranose(9CI) |
CAS | 31178-70-8 |
EINECS | 608-587-0 |
Molecular Formula | C5H10O5 |
Molar Mass | 150.13 |
Melting Point | 154-158°C(lit.) |
Solubility | H2O: 1M at20°C, clear, colorless |
Appearance | Solid |
Color | White to Off-White |
Storage Condition | Refrigerator |
Safety Description | S24/25 - Avoid contact with skin and eyes. S22 - Do not breathe dust. |
WGK Germany | 2 |
RTECS | ZF2285000 |
FLUKA BRAND F CODES | 3 |
Overview | D-xylose (chemical formula: C5H10O5) is a pentalose, a monomer of xylooligosaccharides. In recent years, studies have shown that it has a higher promoting effect on the proliferation of human intestinal bifidobacteria, and the consumption of xylose can improve the microenvironment of the human body, improve the immune system function, and the intake of xylose and calcium at the same time, it can improve the absorption rate and retention rate of calcium in the human body, prevent constipation, and have good compatibility with food, and it is not completely absorbed and utilized by easy diffusion in the human body. It has a certain effect on the decrease of serum triglyceride and low density lipoprotein in experimental animals, and the increase of high density lipoprotein content, and can reduce the level of alanine aminotransferase and aspartate aminotransferase in experimental animals. In addition, from the liver tissue homogenate related enzyme test results analysis, D-xylose can significantly increase the content of lipoprotein lipase, hepatic lipase, glutathione peroxidase, with high dose administration effect is the most significant, these results suggest that D-xylose has a dose-dependent effect on the prevention of hyperlipidemia, and D-xylose has a therapeutic regulatory effect on the occurrence of hyperlipidemia, which can be further studied and explored as an auxiliary therapeutic drug. Figure 1:D-xylose |
Performance | the lipid-lowering effect of D-xylose on hyperlipidemia rats, there was no significant difference in low density lipoprotein (P> 0.05), but the data showed an improvement trend, and the effect was obvious in the high concentration dose group. It is speculated that this result may be related to the shorter experimental time. From the morphological manifestations, D-xylose has a significant protective effect on liver cells after hepatic steatosis. from the liver tissue homogenate related enzyme index test results analysis, D-xylose can significantly increase the content of lipoprotein lipase, hepatic lipase, glutathione peroxidase, the effect of high dose administration is the most significant, suggesting that the effect of D-xylose in preventing hyperlipidemia is dose dependent. |
Application | D-xylose as an emerging functional food ingredient, because of its excellent processing characteristics and a variety of physiological regulation functions, it is widely used in various functional foods, and its physiological regulation function mainly includes the following aspects: regulation of intestinal flora, promoting the proliferation of bifidobacteria D-xylose can selectively promote the proliferation of intestinal Bifidobacteria and other beneficial bacteria, make it become the dominant intestinal flora, regulate the intestinal micro-ecological balance, and promote intestinal health. Bifidobacterium is the normal dwelling flora in the human intestinal tract, which can selectively metabolize D-xylose to produce a large number of short-chain fatty acids, neither E. Coli nor many Clostridia can utilize D-xylose. The short chain fatty acids produced by the metabolism of D-xylose by Bifidobacterium are mainly lactic acid and acetic acid, which can reduce the pH value of the intestine, inhibit the reproduction of other harmful bacteria, and make the indole, phenol, ammonia and cadaverine and other harmful metabolic substances significantly reduced, thereby reducing the risk of colon cancer and other diseases. At the same time, the improvement of the intestinal acidic environment can also stimulate intestinal peristalsis, increase fecal moisture, promote defecation, so as to prevent the occurrence of constipation, reduce the harm of constipation patients, at the same time, D-xylose also has some relief effect on Diarrhea symptoms by regulating intestinal flora, so it is a two-way regulator with laxation and Diarrhea relief. Daily intake of D-xylose 10G, can play a better effect on the whole intestine, so D-xylose is also known as "super Bifidobacterium factor" lower blood pressure, serum cholesterol and blood glucose D-xylose belongs to water-soluble dietary fiber, With some physiological functions of dietary fiber, D-xylose has a good effect on the prevention of hyperlipidemia. Hyperlipidemia mice model was established by feeding high fat diet. The Effects of D-xylose on serum total cholesterol (TC), serum total triglyceride (TG) and high density cholesterol (HDL-C) in hyperlipidemia adult mice were observed. Effect of content. The results show that D-xylose can effectively reduce the serum TC, TG content of hyperlipidemia mice, but has no obvious effect on the increase of low density cholesterol (LDL-C) content. In the intestine, D-xylose has a blocking effect on the absorption of bile acids, and its hydrolytic activity in the intestine is lower than that of other dietary fibers. Therefore, the hydrolysis of carbohydrates in the digestive tract can be blocked, and the blood glucose level can be effectively controlled. Low Calorie: D-xylose is difficult to be decomposed by human digestive enzyme system, saliva, gastric juice, pancreatic juice and small intestinal juice can hardly decompose D-xylose, and its energy value is almost zero, therefore, D-xylose can be used as a raw material for weight loss food and blood sugar regulating food. The anti-caries oligosaccharide does not cause dental caries, and dental caries is caused by the erosion of oral microorganisms, especially Streptococcus mutans, and D-xylose cannot be utilized by oral bacteria or decomposed by oral enzymes. Therefore will not cause dental caries, is conducive to maintaining oral hygiene. When D-xylose and sucrose are used together, they can prevent the use of sucrose by dental caries pathogens to generate tartar, inhibit the adhesion of glucose on the teeth, and prevent the enamel on the surface of the teeth from being ash-removed to generate nutrients, promote the proliferation of Bifidobacterium and other intestinal beneficial bacteria, intestinal beneficial bacteria in the metabolic process, will produce vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin and folic acid and other nutrients, These nutrients can be absorbed and utilized by the human body, and the health care function of supplementing a variety of nutrients in the human body is realized. Figure 2: Application of D-xylose in health products |
side effects | compared with typical statins such as atorvastatin, the side effects of D-xylose are not obvious in animal experiments, and there is no risk of rhabdomyolysis. The main site of action is to regulate the activity of high density lipoprotein receptor (HDL-R), unlike statins, which inhibit 3-hydroxy-3-methylglutaryl coenzyme A ( 3 -hydroxy-3 - methyl glutyl coenzyme A reductase,HMG-Co A) reductase, its mechanism of lipid regulation is weaker for low density lipoprotein (LDL) and HDL-R relative to statins. Xylooligosaccharides by acting on Bifidobacterium (Bifidobacterium) to produce bile acid hydrolase, will bind bile acid free, so that bile acid and cholesterol combined precipitation, with the stool discharge, so as to play a role in reducing lipid, however, xylo-oligosaccharide is difficult to be absorbed in the intestinal tract. In contrast, D-xylose has a more direct effect on hepatic steatosis. |
summary | D-xylose can make lipoprotein lipase (LPL) and hepatic lipase (HL) and glutathione peroxidase (GSH-PX) reduce the content of triglyceride, cholesterol and low density lipoprotein in hyperlipidemia model rats, reduce the degree of liver steatosis and liver cell necrosis, can effectively regulate the lipoprotein lipase (LPL) and hepatic lipase (HL) and other ways to increase the content of high density lipoprotein, promote the transport of cholesterol, in order to achieve the protection of organs and blood vessels and liver, and ultimately can achieve the role of prevention and treatment of fatty liver. |
references | . Product Analysis and Market application of refined D-xylose [J]. Food safety guide, 2013(7):54-55. [2] He Dong, Wang Xiaoyu, Cheng Yugang, etc. Regulation of D-xylose on lipid metabolism in hyperlipidemic rats [J]. Zoological Journal, 2012, 47(6):103-111. [3] Li Honggui, Li Mengyang, Fang Yongxiang. Effect of atorvastatin on low density lipoprotein receptor function in patients with hypercholesterolemia [J]. Central South pharmacy, 2010, 08(8):581-584. [4] Li Wenqin, Zhang Zhiguo, Wang Lijun. Physiological functions of oligosaccharides and their application in food [J]. China food additive, 2008(2):69-72. [5] He Dong, Wang Xiaoyu, Cheng Yugang, etc. Protective effect of D-xylose on steatosis of alcoholic liver cells [J]. World Chinese Journal of Gastroenterology, 2012(24): 269-2264. |