D6-Retroprogesterone
Dydrogesterone
CAS: 152-62-5
Molecular Formula: C21H28O2
D6-Retroprogesterone - Names and Identifiers
| Name | Dydrogesterone |
| Synonyms | prodel terolut retrone Dydrogesterone DYDROGESTERONE Dyhydrogesterone 10a-Isopregnenone D6-Retroprogesterone 6-Dehydroretroprogesterone .DELTA.6-Retroprogesterone retro-6-dehydroprogesterone DYDROGESTERONE, BP STANDARD DYDROGESTERONE, USP STANDARD 6-Dehydro-9b,10a-progesterone 9b,10a-Pregna-4,6-diene-3,20-dione (9b,10a)-Pregna-4,6-diene-3,20-dione (9beta,10xi)-pregna-4,6-diene-3,20-dione 6-Dehydro-9.beta.,10.alpha.-progesterone (9beta,10alpha)-Pregna-4,6-diene-3,20-dione 9beta,10alpha-Pregna-4,6-diene-3,20-dione (8CI) |
| CAS | 152-62-5 |
| EINECS | 205-806-8 |
| InChI | InChI=1/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,12,16-19H,6-11H2,1-3H3/t16-,17+,18-,19+,20?,21+/m0/s1 |
| InChIKey | JGMOKGBVKVMRFX-HQZYFCCVSA-N |
D6-Retroprogesterone - Physico-chemical Properties
| Molecular Formula | C21H28O2 |
| Molar Mass | 312.45 |
| Density | 1.0697 (rough estimate) |
| Melting Point | 168-173°C |
| Boling Point | 392.36°C (rough estimate) |
| Specific Rotation(α) | D25 -484.5° (chloroform) |
| Flash Point | 172.2°C |
| Solubility | DMSO : 33.33 mg/mL (106.67 mM; Need ultrasonic) |
| Vapor Presure | 9.55E-09mmHg at 25°C |
| Appearance | neat |
| Color | White to Light Yellow |
| Storage Condition | 2-8°C |
| Refractive Index | 1.4900 (estimate) |
| In vitro study | Dydrogesterone acts on endothelial cells alone or in combination with estrogens, producing a neutral effect on NO synthesis and on the activity and expression of eNOS. |
| In vivo study | Dydrogesterone abolished the stress-induced increase in miscarriage rate in mice. Dydrogesterone brought the percentage of CD8 uterine cells back to the level of control mice. Dydrogesterone significantly reduced the relative number of mouse TNF-α-producing uterine cells after 7.5,9.5, and even 10.5 days in mice. When Dydrogesterone acted on stressed mice, the percentage of uterine cells IL-4 pregnancy protection increased 7.5 days after the start of pregnancy, and even more significantly, and this increase continued until day 10.5. Dydrogesterone abolished the elevated rate of miscarriage in mice subjected to sound stress. Dydrogesterone acts on stressed mice and increases plasma PIBF levels, but does not affect progesterone levels. Dydrogesterone significantly increased the percentage of IL-4-positive decidual immune cells in stressed mice. |
D6-Retroprogesterone - Risk and Safety
| UN IDs | UN 3077 9 / PGIII |
| Toxicity | LD50 oral in rat: > 4600mg/kg |
D6-Retroprogesterone - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.201 ml | 16.003 ml | 32.006 ml |
| 5 mM | 0.64 ml | 3.201 ml | 6.401 ml |
| 10 mM | 0.32 ml | 1.6 ml | 3.201 ml |
| 5 mM | 0.064 ml | 0.32 ml | 0.64 ml |
Last Update：2024-01-02 23:10:35
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