DERAMCICLANE
DERAMCICLANE
CAS: 120444-71-5
Molecular Formula: C20H31NO
DERAMCICLANE - Names and Identifiers
DERAMCICLANE - Physico-chemical Properties
| Molecular Formula | C20H31NO |
| Molar Mass | 301.47 |
| Density | 1.01±0.1 g/cm3(Predicted) |
| Boling Point | 375.2±25.0 °C(Predicted) |
| pKa | pKa 9.61±0.03(H2O t=25±0.1 I=0.1(NaCl)) (Uncertain) |
| Storage Condition | Room Temprature |
| In vitro study | Deramciclane is a novel anxiolytic agent that binds with high affinity to 5-HT 2A / 2C receptors. The interactions of Deramciclane with the serotonin 5-HT 2C receptor are characterized further using receptor phosphoinositide hydrolysis assays and receptor autoradiography. Deramciclane antagonizes 5-HT 2C receptor mediated 5-HT-stimulated phosphoinositide hydrolysis with an IC 50 value of 168 nM. Deramciclane also decreases basal phosphoinositide hydrolysis by up to 33% (EC 50 = 93 nM) in a physiological system in the choroid plexus, suggesting that Deramciclane possesses inverse agonist properties at this receptor. |
| In vivo study | Deramciclane 3 and 10 mg/kg does not change the dopamine levels significantly at any time point versus the basal level whereas 30 mg/kg of Deramciclane significantly increases the levels at 40-100 min and at 160-240 min (P<0.05). Deramciclane is a putative antiserotonergic compound that reduces 5-HT-induced phosphoinositol hydrolysis and a variety of actions caused by serotonergic agonists. The receptor binding profile of Deramciclane is rather similar to that of ritanserin. Deramciclane has a high affinity for 5-HT 2A and 5-HT 2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT 2C receptors without direct stimulatory agonist effects. Deramciclane has been shown to have anxiolytic-like activity in several animal tests. |
DERAMCICLANE - References
| biological activity | Deramciclane has high affinity for 5-HT2A and 5-HT2C receptors. Deramciclane, as an antagonist of two receptor subtypes, has inverse agonist properties at the 5-HT2C receptor and no direct stimulating agonist. |
Last Update：2024-04-09 20:52:54
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CAS: 120444-71-5
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Mobile: 18021002903
QQ: 3008007409
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CAS: 120444-71-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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