DIM-C-PPHOCH3
3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole)
CAS: 33985-68-1
Molecular Formula: C24H20N2O
DIM-C-PPHOCH3 - Names and Identifiers
| Name | 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole) |
| Synonyms | C-DIM5 DIM-C-pPhOCH3 DIM-C-PPHOCH3 DIM-C-pPhOCH3(C-DIM5) Bis(1H-indol-3-yl)(4-methoxyphenyl)]methane 1,1-bis(3′-Indolyl)-1-(p-methoxyphenyl)methane 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole) 1H-Indole, 3,3'-[(4-methoxyphenyl)methylene]bis- |
| CAS | 33985-68-1 |
| EINECS | 604-604-1 |
DIM-C-PPHOCH3 - Physico-chemical Properties
| Molecular Formula | C24H20N2O |
| Molar Mass | 352.43 |
| Density | 1.251±0.06 g/cm3(Predicted) |
| Melting Point | 187-189 °C |
| Boling Point | 592.7±50.0 °C(Predicted) |
| Solubility | DMSO: ≥30mg/mL |
| Appearance | powder |
| Color | off-white to light yellow |
| pKa | 16.63±0.30(Predicted) |
| Storage Condition | 2-8°C |
| Use | DIM-C-pPhOCH3 is a Nur77 agonist. Nur77 is an orphan nuclear receptor. |
| In vitro study | DIM-C-pPhOCH 3 decreases survival and induces apoptosis in RKO colon cancer cells, and this is accompanied by induction of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) protein. DIM-C-pPhOCH 3 also induces Nur77-independent apoptosis. DIM-C-pPhOCH 3 (10 μM) inhibits cell growth after treatment for 24, 48, or 72 h, and the maximum inhibitory response is observed after 72 h, where there is considerable cell detachment and dead cells. The growth-inhibitory effects observed for DIM-C-pPhOCH 3 after 72 h are also accompanied by several markers of apoptosis, including PARP cleavage and cleavage of caspase-3, caspase-9, and caspase-8. PARP cleavage is also observed after treatment of RKO cells for 48 h with DIM-C-pPhOCH 3 . |
| In vivo study | DIM-C-pPhOCH 3 (25 mg/kg/d) also inhibits tumor growth in athymic nude mice bearing RKO cell xenografts. The effects of DIM-C-pPhOCH 3 (25 mg/kg/d) on colon tumor growth are also investigated in athymic nude mice bearing RKO cell xenografts. Treatment with the DIM-C-pPhOCH 3 significantly decreases tumor volumes and final tumor weights compared with corn oil controls. |
DIM-C-PPHOCH3 - Risk and Safety
| WGK Germany | 3 |
DIM-C-PPHOCH3 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.837 ml | 14.187 ml | 28.375 ml |
| 5 mM | 0.567 ml | 2.837 ml | 5.675 ml |
| 10 mM | 0.284 ml | 1.419 ml | 2.837 ml |
| 5 mM | 0.057 ml | 0.284 ml | 0.567 ml |
Last Update：2024-01-02 23:10:35
DIM-C-PPHOCH3 - Reference Information
| biological activity | C-DIM5 (DIM-C-pPhOCH3) it is an agonist of orphan nuclear receptor Nur77 (Nerve growth factor-induced bα (ngfi-bα)/nuclear receptor 4A1 (NR4A1)). C- DIM5 (DIM-C-pPhOCH3) reduces survival and induces apoptosis in RKO colon cancer cells. |
| Target | Value |
Last Update：2024-04-09 02:00:14
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Spot supply
Product Name: 3,3'-((4-Methoxyphenyl)Methylene)bis(1H-indole) Visit Supplier Webpage Request for quotationCAS: 33985-68-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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