DIVIDEND
Difenoconazole
CAS: 119446-68-3
Molecular Formula: C19H17Cl2N3O3
DIVIDEND - Names and Identifiers
DIVIDEND - Physico-chemical Properties
| Molecular Formula | C19H17Cl2N3O3 |
| Molar Mass | 406.26 |
| Density | 1.4916 (rough estimate) |
| Melting Point | 76°C |
| Boling Point | 220°C |
| Flash Point | 284.6°C |
| Water Solubility | 3.3 mg/L (20 ºC) |
| Solubility | Water soluble 3.3 mg/L (20°C) |
| Vapor Presure | 3.3 x l0-8 Pa (25 °C) |
| Appearance | Colorless solid |
| Merck | 13,3160 |
| BRN | 9073356 |
| pKa | 2.94±0.12(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
| Refractive Index | 1.6140 (estimate) |
| MDL | MFCD00144119 |
| Physical and Chemical Properties | Melting Point: 76°C Boiling Point: 220°C storage conditions: 0-6°C water solubility: 3.3 mg/L (20°C) Merck:13,3160 colorless solid |
| Use | Oxadiazole is a triazole fungicide with systemic absorption, which is a sterol demethylation inhibitor and has a wide bactericidal spectrum. It belongs to triazole fungicide, with internal absorption and broad bactericidal spectrum, and is a sterol demethylation inhibitor. Broad bactericidal spectrum for foliar treatment or seed treatment |
DIVIDEND - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R41 - Risk of serious damage to eyes R43 - May cause sensitization by skin contact R50 - Very Toxic to aquatic organisms R20/22 - Harmful by inhalation and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | XZ4380000 |
| Toxicity | LD50 in rats (mg/kg): 1453 orally; in rabbits: >2010 dermally (Ruess) |
DIVIDEND - Reference
| Reference Show more | 1. Zhang Min, Zhao Chi Na, Han Fei, et al. Screening of 5 Sterol Biosynthesis Inhibitors (SBIs) antifungal drugs against 9 plant pathogenic fungi [J]. Journal of Pesticide 2020. 2. Pan Jialiang, Yao Hanwen, Geng Zheng, et al. Synergistic effect of matrine on fungicide against pecan dry rot [J]. Journal of Northeast Forestry University, 2018, 46(001):101-104. |
DIVIDEND - Introduction
Water soluble 3.3mg/L(20 ℃).
Last Update：2022-10-16 17:12:31
DIVIDEND - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Introduction | Difenoconazole, also known as oxoconazole, trade name "Shigao", belongs to triazole fungicides and is a sterol demethylation inhibitor. It has the characteristics of high efficiency, broad-spectrum, low toxicity, and low dosage. It is an excellent variety of triazole fungicides. It has strong absorption and inhibits the biosynthesis of ergosterol in bacterial cells, thereby destroying the cell membrane structure and function of pathogenic bacteria, used in fruit trees, vegetables, wheat, potatoes, beans, melons and other crops, and has a good protection and treatment effect on vegetables, melons and fruits and other fungal diseases. The characteristics of "three nos" (no pollution of the environment, no pollution of agricultural products, no killing of natural enemies), it is an ideal fungicide for preventing and controlling citrus scab, spotted leaf disease and other crop resistant diseases in my country and even in the world. |
| mechanism of action | difenoconazole water dispersible granules are beige to brown fine granules. Difenoconazole has a strong inhibitory effect on the spore formation of plant pathogens, and can inhibit the maturation of conidia, thereby controlling the further development of the disease. The mode of action of fenoconazole is to interfere with the C14 demethylation of pathogenic bacteria cells and inhibit the biosynthesis of ergosterol, so that the sterol stays in the cell membrane, damages the physiological function of the membrane, and leads to the death of fungi. Difenoconazole bactericidal spectrum |
| features | ① internal absorption and conduction, broad bactericidal spectrum difenoconazole is a triazole fungicide, which is an efficient, safe, low toxic and broad spectrum fungicide, which can be absorbed by plants and has strong infiltration effect. within 2 hours after application, it is absorbed by crops and has the characteristics of upward conduction, it can protect the newborn young leaves, flowers, and fruits from germs. It can be treated with one medicine and has good control effect on various fungal diseases. It can effectively prevent and treat scab, leaf spot, powdery mildew and rust of vegetables, and has both preventive and therapeutic effects. (2) Rain-resistant scouring, drug effect lasting adhesion on the leaf surface of the agent rain-resistant scouring, from the leaf volatilization is very little, even under high temperature conditions also show a more durable bactericidal activity, than the general fungicide lasting 3~4 days. ③The dosage form is advanced, and the crop safety water dispersible granule consists of active ingredients, dispersants, wetting agents, disintegrating agents, defoamers, adhesives, anti-caking agents and other additives, through micro-refinement, spray drying and other processes Granulation. The water can be quickly disintegrated and dispersed, forming a high suspension dispersion system, no dust influence, and safe for users and the environment. It does not contain organic solvents and is safe for recommended crops. (4) difenoconazole can be mixed with propiconazole, azoxystrobin and other fungicides for the production of compound fungicides. |
| Synthesis method | Using m-dichlorobenzene as raw material, through acylation, etherification, bromination, cyclization and condensation reactions, difenoconazole is finally synthesized. Fig. 1 shows the synthesis route of difenoconazole |
| use | it has excellent control effect on grape, peanut, kernel fruit, potato, wheat, vegetable and other crops. (2016-01-13) oxazole is a triazole fungicide, with systemic, is a sterol demethylation inhibitor, and has a broad bactericidal spectrum. oxetherazole is a triazole fungicide, with systemic, is a sterol demethylation inhibitor, and has a broad bactericidal spectrum. It is a triazole fungicide with systemic and broad bactericidal spectrum. It is a sterol demethylation inhibitor. Wide sterilization spectrum, used for foliar treatment or seed treatment Wide sterilization spectrum, used for foliar treatment or seed treatment |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-10 22:29:15
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