DL-1-Amino-2-propanol
DL-1-Amino-2-propanol
CAS: 78-96-6
Molecular Formula: C3H9NO
DL-1-Amino-2-propanol - Names and Identifiers
| Name | DL-1-Amino-2-propanol |
| Synonyms | MIPA THREAMINE Aminopropanol Amino-2-propanol Iso-propanolamine 2-aminopropan-2-ol 1-AMINOISOPROPANOL 1-AMINO-2-PROPANOL RARECHEM AL BW 2385 DL-Isopropanolamine MONOISOPROPANOLAMINE Monoisopropanolamine DL-1-Amino-2-propanol 1-AMINOISOPROPYL ALCOHOL 1,1',1''-nitrilotripropan-1-ol (2R)-2-hydroxypropan-1-aminium |
| CAS | 78-96-6 |
| EINECS | 201-162-7 |
| InChI | InChI:1S/C3H9NO/c1-3(5)2-4/h3,5H,2,4H2,1H3 |
| InChIKey | HXKKHQJGJAFBHI-UHFFFAOYSA-N |
DL-1-Amino-2-propanol - Physico-chemical Properties
| Molecular Formula | C3H9NO | |||
| Molar Mass | 75.11 | |||
| Density | 0.973 g/mL at 25 °C (lit.) | |||
| Melting Point | -2 °C (lit.) | |||
| Boling Point | 160 °C (lit.) | |||
| Flash Point | 165°F | |||
| JECFA Number | 1591 | |||
| Water Solubility | freely soluble | |||
| Vapor Presure | <1 mm Hg ( 20 °C) | |||
| Vapor Density | 2.6 (vs air) | |||
| Appearance | Liquid | |||
| Color | Clear | |||
| Odor | slt ammonia odor | |||
| BRN | 605275 | |||
| pKa | 12.92±0.35(Predicted) | |||
| PH | 11.3 (10g/l, H2O, 20℃) | |||
| Storage Condition | 2-8°C | |||
| Stability | Stable. Substances to be avoided include strong oxidizing agents. Combustible. Hygroscopic. | |||
| Sensitive | Hygroscopic | |||
| Explosive Limit | 1.9-10.4%(V) | |||
| Refractive Index | n20/D 1.4478(lit.) | |||
| MDL | MFCD00008139 | |||
| Physical and Chemical Properties | has optical rotation. Normal temperature is liquid. The freezing point is 1.7 °c, the boiling point is 160 °c, and the flash point is 73 °c. Density 0.9681, viscosity 31 MPa · sec (20 °c). Refractive index 1.4479, soluble in water and ethanol, aqueous solution is alkaline, can react with acid to generate Ester, and acid halide reaction to generate amide compounds.
| |||
| Use | 1.4479, soluble in water and ethanol, the aqueous solution is alkaline, can react with acid to produce ester, and acid halide reaction to produce amide compounds. It can be used as a raw material for surfactants, as well as fiber industry refining agents, antistatic agents, dyeing aids and fiber wetting agents. It can also be used for the preparation of synthetic detergents, cosmetics, lubricating oils, cutting oils, plasticizers, emulsifiers, and solvents. In the textile, printing and dyeing and other aspects of processing production aids. Can be used for electroplating cleaning, surfactant, medicine and other aspects. |
DL-1-Amino-2-propanol - Risk and Safety
| Risk Codes | R34 - Causes burns R21/22 - Harmful in contact with skin and if swallowed. |
| Safety Description | S23 - Do not breathe vapour. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. |
| UN IDs | UN 2735 8/PG 2 |
| WGK Germany | 1 |
| RTECS | UA5775000 |
| TSCA | Yes |
| HS Code | 29221980 |
| Hazard Class | 8 |
| Packing Group | II |
| Toxicity | LD50 orl-rat: 1715 mg/kg GTPZAB 30(7),46,86 |
DL-1-Amino-2-propanol - Upstream Downstream Industry
| Downstream Products | Tris(1-[2-methyl]aziridinyl)phosphine oxide |
DL-1-Amino-2-propanol - Nature
Open Data Verified Data
isopropanolamine is optically active and liquid at room temperature. The freezing point was 1.4 °c. Boiling point 160 °c. Flash point 80 °c. Relative density 0.9681. Viscosity (20 deg C) 31mPa.s. Refractive index 465. Soluble in water and ethanol, the aqueous solution is alkaline, can react with acid to generate Ester, and acid halide reaction to generate Amido compounds.
Last Update：2024-01-02 23:10:35
DL-1-Amino-2-propanol - Preparation Method
Open Data Verified Data
This product can be prepared by the reaction of propylene oxide and ammonia. After the propylene oxide and ammonia are mixed, the addition reaction is carried out by preheating, and the resulting mixture is deammoniated, dehydrated, subjected to reduced pressure distillation and rectification to obtain a finished product. Different proportions of isopropanolamine, diisopropanolamine and triisopropanolamine can be obtained by adjusting the ratio of propylene oxide to ammonia during the reaction.
Last Update：2022-01-01 10:35:31
DL-1-Amino-2-propanol - Use
Open Data Verified Data
This product can be used as the raw material of surfactant, refining agent, antistatic agent, dyeing auxiliary and fiber wetting agent in fiber industry. It can also be used for the preparation of antioxidants, plasticizers, emulsifiers and solvents for synthetic detergents, cosmetics, lubricating oils, cutting oils.
Last Update：2022-01-01 10:35:30
DL-1-Amino-2-propanol - Safety
Open Data Verified Data
- isopropanolamine is not particularly toxic, because it has an amino group, and has a certain degree of damage to the eye and skin. In rats, the oral toxicity LD50 was 4.26g/kg. The human LD50 was 4.3g/kg.
- with iron drum packaging, each barrel lOOkg, Foreign also useful 200kg barrel. Pay attention to fire prevention and heat protection during storage and transportation.
Last Update：2022-01-01 10:35:32
DL-1-Amino-2-propanol - Reference Information
| FEMA | 3965 | 1-AMINO-2-PROPANOL |
| freezing point | 1.4 ℃ |
| LogP | -0.93 at 23℃ |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Use | (1) reaction with fatty acids to produce fatty acid isopropanolamides (alkyl isopropanolamides) and esters, because of its excellent foaming, foam stability and ability to dissolve fats and oils, it can be used as a synthetic detergent for industrial use. (2) the product obtained with thioglycolic acid can be used as a base for cosmetics. (3) because of good hygroscopicity, and has a weak alkaline, it can be used as raw materials for surfactants, refining agent and fiber industry, antistatic agent, dyeing auxiliaries and fiber wetting agent. (4) its phosphate and nitrite can be used as antioxidants for various lubricating oils and cutting oils. (5) the reaction products with various acids and higher fatty ketones can be used as plasticizers, emulsifiers and solvents. The isopropanolamine mixture has a strong ability to dissolve hydrocarbons, and a stable emulsion can be obtained by stirring kerosene, halogenated hydrocarbons, naphtha, etc. with isopropanolamine (4%) and oleic acid (15%) in water. Salts with long-chain fatty acids can be used as vinyl acetate resin emulsifier, Emulsion Stability, color stability. can be used as raw materials of surfactant and Fiber Industry refining agent, antistatic agent, dyeing auxiliary and fiber wetting agent, etc. Used as surfactant, rubber vulcanization accelerator and solvent 1-amino -2-propanol (MIPA) is an important fine chemical raw materials, widely used, commonly used as surfactants, metal processing fluids, paint Coatings, textile printing and dyeing, personal care varieties, water treatment agents, pharmaceutical pesticide intermediates, one of the raw materials. The main uses of 1-amino-2-propanol (isopropanolamine) are as follows:(1) reaction with fatty acids to form fatty acid isopropanolamides (alkyl isopropanolamides) and esters, because of its excellent foaming, foam stability and ability to dissolve fats and oils, it can be used as a synthetic detergent for industrial use. (2) the product obtained with thioglycolic acid can be used as a base for cosmetics. (3) because of good hygroscopicity, and has a weak alkaline, it can be used as raw materials for surfactants, refining agent and fiber industry, antistatic agent, dyeing auxiliaries and fiber wetting agent. (4) its phosphate and nitrite can be used as antioxidants for various lubricating oils and cutting oils. (5) the reaction products with various acids and higher fatty ketones can be used as plasticizers, emulsifiers and solvents. The isopropanolamine mixture has a particularly strong ability to dissolve hydrocarbons, Kerosene, halogenated hydrocarbons, naphtha and the like are stirred with isopropanolamine (4%) and oleic acid (15%) in water to obtain a stable emulsion. Salts with long-chain fatty acids can be used as vinyl acetate resin emulsifier, Emulsion Stability, color stability. rate of 1.4479, soluble in water and ethanol, the aqueous solution is alkaline, can react with acid to produce ester, and acid halide reaction to produce amide compounds. It can be used as a raw material for surfactants, as well as fiber industry refining agents, antistatic agents, dyeing aids and fiber wetting agents. It can also be used for the preparation of synthetic detergents, cosmetics, lubricating oils, cutting oils, plasticizers, emulsifiers, and solvents. In the textile, printing and dyeing and other aspects of processing production aids. Can be used for electroplating cleaning, surfactant, medicine and other aspects. biochemical research used in plastics, paints, cutting oils and special cleaning agents. This product can be used as surfactant, fiber industry refining agent, antistatic agent, dyeing agent, fiber wetting agent, also can be used as synthetic detergent, cosmetic lubricating oil, cutting oil antioxidant, plasticizer, emulsifier and solvent preparation. |
| preparation | propylene oxide and ammonia water at a concentration of 95wt% were prepared in a molar ratio of 1:1.0, input the mixer with metering pump respectively, and control the temperature in the mixer to be 0 ℃ and the pressure to be 3.0MPa; Continuously pass the mixed liquid into the micro-channel reactor, and the materials are reacted in the channels of the reaction section of the reactor, the temperature is 60 ℃, the pressure is 3.0MPa, after the residence time is 0.1s, the temperature is quickly cooled in the cooling section of the microchannel reactor to terminate the reaction, the outlet temperature is 0 ℃, the residence time is 2S, the specific cooling rate was controlled at about 1800-2000 °c/min. The low boiling material was then removed via a gas stripping column to give the product 1-amino-2-propanol in an amount of 99.2%. In this embodiment, the micro-channel reactor is specifically made of stainless steel, wherein the inner diameter of the micro-channel is 0.05, and the length of the micro-channel is 0.8m. |
| production method | can be obtained by reacting propylene oxide with ammonia. After mixing propylene oxide with ammonia, an addition reaction is carried out by preheating, and the resulting mixture is deammoniated, dehydrated, subjected to vacuum distillation, and rectified to obtain a finished product. Different proportions of isopropanolamine, diisopropanolamine and triisopropanolamine can be obtained by adjusting the ratio of propylene oxide to ammonia during the reaction. |
| category | flammable liquid |
| toxicity grade | poisoning |
| Acute toxicity | oral-rat LD50: 1715 mg/kg; Intraperitoneal-mouse LDL0: 250 mg/kg |
| stimulation data | Skin-rabbit 485 mg moderate; Eye-rabbit 0.97 mg severe |
| flammability hazard characteristics | near-heat, flame, spark and strong oxidant flammability; Burning in contact with large surface area of nitric acid fiber; toxic nitrogen oxide smoke from hyperthermia |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant |
| fire extinguishing agent | alcohol foam |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:11
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