DL-Adrenaline
DL-Adrenalin
CAS: 329-65-7
Molecular Formula: C9H13NO3
DL-Adrenaline - Names and Identifiers
| Name | DL-Adrenalin |
| Synonyms | dl-adrenalin DL-Adrenalin DL-ADRENALINE DL-Adrenaline DL-Epinephrine DL-EPINEPHRINE 1-(3,4-Dihydroxyphenyl)-2-(methylamino)ethanol 1-(3,4-dihydroxyphenyl)-2-(methylamino)ethanol 4-(1-HYDROXY-2-METHYLAMINO-ETHYL)-BENZENE-1,2-DIOL 4-[1-HYDROXY-2-(METHYLAMINO)ETHYL]-1,2-BENZENEDIOL 4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol 3,4-Dihydroxy-1-[1-hydroxy-2-(methylamino)-ethyl]benzene |
| CAS | 329-65-7 |
| EINECS | 206-347-6 |
| InChI | InChI=1/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3 |
DL-Adrenaline - Physico-chemical Properties
| Molecular Formula | C9H13NO3 |
| Molar Mass | 183.2 |
| Density | 1.1967 (rough estimate) |
| Melting Point | 197°C (dec.)(lit.) |
| Boling Point | 316.88°C (rough estimate) |
| Specific Rotation(α) | -0.5～+0.5°(D/20)(c=1,0.1mol/l HCl) |
| Water Solubility | Sparingly soluble |
| Appearance | Powder |
| Merck | 14,3619 |
| pKa | 9.60±0.10(Predicted) |
| Storage Condition | 2-8°C |
| Sensitive | Light Sensitive |
| Refractive Index | 1.4760 (estimate) |
DL-Adrenaline - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | R24 - Toxic in contact with skin R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | DO2975000 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
DL-Adrenaline - Standard
Authoritative Data Verified Data
This product is (R)-4-[2-(methylamino)-l-Hydroxyethyl]-1, 2-benzenediol. The content of C9H13N03 shall not be less than 98.5% calculated as dry product.
Last Update：2024-01-02 23:10:35
DL-Adrenaline - Trait
Authoritative Data Verified Data
- This product is white or white crystalline powder; Odorless; Contact with air or sun exposure, easy to Oxidative deterioration; Unstable in neutral or alkaline aqueous solution; the saturated aqueous solution showed weak alkaline reaction.
- This product is very slightly soluble in water, insoluble in ethanol, chloroform, acetic acid, fatty oil or volatile oil; Soluble in inorganic acid or sodium hydroxide solution, insoluble in ammonia solution or sodium carbonate solution.
melting point
The melting point of this product (General rule 0612) is 206~212 ℃, and it is decomposed at the same time during melting.
specific rotation
take this product, precision weighing, and hydrochloric acid solution (9-200) dissolved and quantitatively diluted into solution containing 20mg per lml, determination according to law (General 0621), the specific rotation is from one to 50.0 ° to one to 53.5 °.
Last Update：2022-01-01 13:35:22
DL-Adrenaline - Differential diagnosis
Authoritative Data Verified Data
- take about 2mg of this product, add 2-3 drops of hydrochloric acid solution (9-1000) to dissolve, add 2ml of water and 1 drop of ferric chloride test solution, that is, it is green; Add 1 drop of ammonia test solution, it turns purple and finally purplish red.
- Take 10 mg of this product, add 2ml of hydrochloric acid solution (9-1000) to dissolve, add 10 drops of hydrogen peroxide test solution, and boil to show blood red.
Last Update：2022-01-01 13:35:23
DL-Adrenaline - Exam
Authoritative Data Verified Data
clarity and color of acidic solution
Check the solution under the item of specific rotation, should be clear and colorless, such as color, compared with the same volume of control solution (take the yellow No. 3 Standard Colorimetric solution or orange-red No. 2 Standard Colorimetric solution 5ml with water 5ml) (General rule 0901 first method), should not be deeper.
ketone body
take this product, add hydrochloric acid solution (9-2000) made per 1 ml containing 2.0 mg of the solution, according to UV-visible spectrophotometry (General 0401), measured at a wavelength of 0.05 NM, the absorbance should not exceed.
Related substances
take this product about 10mg, precision weighing, 10ml flask t plus hydrochloric acid 0.1ml to dissolve, dilute to the scale with mobile phase, shake well, as a test solution; Take 1ml of the test solution with precision, put it in a 500ml measuring flask, dilute to the scale with mobile phase, another 50mg,l50ml measuring flask was filled with 1ml of concentrated hydrogen peroxide solution, which was left overnight, and 0.5ml of hydrochloric acid was added, as an oxidation destruction solution; Take an appropriate amount of norepinephrine bitartrate control, add the oxidation destruction solution to dissolve and dilute to make a solution containing 20ug per 1ml as a system-applicable solution. According to the test of high performance liquid chromatography (General rule 0512), silica gel bonded with eighteen alkyl silane was used as the filler; Tetramethylammonium hydrogen sulfate solution (tetramethylammonium hydrogen sulfate 4.Og, sodium heptane sulfonate 1. LG, 0.1 mol/L ethylene diamine tetraacetic acid disodium solution 2ml, dissolved in water and diluted to 3.5 ml)-methanol (95:5)(with 1 mol/L; Sodium oxide solution to adjust the pH value to) as mobile phase; the flow rate was 2ml per minute and the detection wavelength was 205nm. Take the applicable solution 20 u1 of the system and inject it into the liquid chromatograph. There should be two unknown impurity peaks between the norepinephrine peak and the epinephrine peak, and the number of theoretical plates should not be less than 3000 based on the norepinephrine peak, the degree of separation of adrenaline peak and adjacent impurity peak shall meet the requirements. The test solution and the control solution are accurately sampled at 20 u1 respectively, and human liquid chromatograph is injected respectively, and the chromatogram is recorded. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.2%), the sum of each impurity peak area shall not be greater than 2.5 times (0.5%) of the main peak area of the control solution.
loss on drying
take this product, put it in a phosphorus pentoxide dryer, and dry it under reduced pressure for 18 hours. The weight loss shall not exceed 1.0% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Last Update：2022-01-01 13:35:24
DL-Adrenaline - Content determination
Authoritative Data Verified Data
take this product about 0.15g, precision weighing, add ice vinegar 10ml, shake dissolved, add crystal violet indicator solution 1 drop, with high gas acid titration solution (0.1 mol/L) titration to the solution is blue-green, and the result of the titration is corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 18.32mg of C9H13NO3.
Last Update：2022-01-01 13:35:24
DL-Adrenaline - Category
Authoritative Data Verified Data
adrenergic receptor agonists.
Last Update：2022-01-01 13:35:24
DL-Adrenaline - Storage
Authoritative Data Verified Data
under reduced pressure, seal and store in a cool place.
Last Update：2022-01-01 13:35:25
DL-Adrenaline - Epinephrine hydrochloride injection
Authoritative Data Verified Data
- This product is the right amount of epinephrine and hydrochloric acid, and the right amount of sodium chloride to make isotonic sterile aqueous solution. Adrenaline (C9H13N03) shall be between 85,0 and 115.0% of the labeled amount.
- suitable stabilizer can be added to this product.
trait
This product is colorless or almost colorless clear liquid; Exposed to sunlight or contact with the air deterioration.
identification
take 2ml of this product, add 1 drop of ferric chloride test solution, which is green; Add 1 drop of ammonia test solution, which turns purple and finally turns purple.
examination
- the pH value should be 2.5 to 5.0 (General 0631).
- precise amount of related substances: Take appropriate amount of this product and quantitatively dilute it with mobile phase to make a solution containing 0.2mg of epinephrine per 1 ml as a test solution; Take appropriate amount of norepinephrine bitartrate reference product, precision weighing, adding mobile phase to dissolve and quantitatively dilute to make a solution containing norepinephrine in each lml, Take 5ml of precision measurement, put it in a 50ml measuring flask, and add 5ml of human test solution with precision, dilute to the scale with mobile phase as a control solution; Take an appropriate amount of sodium metabisulfite, dissolve and dilute with mobile phase to make a solution containing 0.2mg per 1 ml as a blank excipient solution. According to the chromatographic conditions under the item of epinephrine related substances, the number of theoretical plates shall not be less than 2000 calculated by epinephrine peak, and the separation degree of norepinephrine peak and epinephrine peak shall be greater than 4.0. Take 20 u1 of each of the above three solutions with precision, inject human liquid chromatography respectively, and record the chromatogram to 3 times of the retention time of the main component peak. If there is a peak consistent with the retention time of norepinephrine in the chromatogram of the test solution, the peak area shall be calculated according to the external standard method, and the of the labeled amount of epinephrine shall not be passed.
- 1.0%; If there are other impurity peaks, the sodium metabisulfite peak and the previous excipient peak are subtracted. The maximum chromatographic peak adjacent to the excipient peak shall not be greater than the peak area of epinephrine peak in the control solution (10% ) , the sum of the peak areas of other impurities shall not be greater than 0.1 times (1.0%) The Peak area of adrenaline in the control solution.
- osmolality the osmolality shall be 0632-315mOsmol/kg for determination according to law (General rule 257).
- bacterial endotoxin take this product, according to the law to check (General 1143), each 1 mg of adrenaline containing endotoxin should be less than 30EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
take an appropriate amount of this product and quantitatively dilute it with mobile phase to make a solution containing 0.2mg of adrenaline per lml as a test solution. Take an appropriate amount of adrenaline reference and weigh it accurately, add an appropriate amount of mobile phase, add 2-3 drops of glacial acetic acid, shake to dissolve epinephrine, quantitatively dilute with mobile phase to prepare a solution containing 0.2mg of epinephrine per 1 ml, and shake well to be used as a reference solution. In addition to the detection wavelength of 280nm, according to the chromatographic conditions under the item of epinephrine related substances, 20ul of each of the test solution and the reference solution was accurately measured and injected into the liquid chromatograph respectively, and the chromatograms were recorded, according to the external standard method to calculate the peak area, that is.
category
with epinephrine.
specification
calculated by C9H13N03 (l)0.5: 0.5mg( 2 ) lml:lmg
storage
shade, close, and store in a cool place.
Last Update：2022-01-01 13:35:26
DL-Adrenaline - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | DL-Adrenaline is a hormone, a neurotransmitter secreted by the adrenal medulla. |
| Target | Value |
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: Norepinephrine Impurity 8 Visit Supplier Webpage Request for quotationCAS: 329-65-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: DL-Adrenalin Visit Supplier Webpage Request for quotationCAS: 329-65-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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