DMDO
Dimethyldioxolone
CAS: 37830-90-3
Molecular Formula: C5H6O3
DMDO - Names and Identifiers
| Name | Dimethyldioxolone |
| Synonyms | DMDO DIMETHYLDIOXOLONE Dimethyldioxolone 5-Dimethyl-1,3-dioxol-2-one 4,5-DIMETHYL-1,3-DIOXOL-2-ONE 1,3-Dioxol-2-one,4,5-dimethyl 4,5-Dimethyl-1,3-dioxol-2-one 4,5-Dimethyl-1,3-dioxolen-2-one 1,3-DIOXOL-2-ONE, 4,5-DIMETHYL- 4,5-Dimethyl-1,3-dioxolen-3-one 4,5-dimethyl-1,3-dioxolene-2-one 4,5-dimethyl-2-oxo-1,3-dioxolene 4,5-DIMETHYL-1,3-DIOXOLENE-2-ONE (DMDO) |
| CAS | 37830-90-3 |
| EINECS | 678-111-4 |
| InChI | InChI=1/C5H6O3/c1-3-4(2)8-5(6)7-3/h1-2H3 |
| InChIKey | QYIOFABFKUOIBV-UHFFFAOYSA-N |
DMDO - Physico-chemical Properties
| Molecular Formula | C5H6O3 |
| Molar Mass | 114.1 |
| Density | 1.181±0.06 g/cm3(Predicted) |
| Melting Point | 78°C |
| Boling Point | 130 °C / 6mmHg |
| Flash Point | 55.8°C |
| Solubility | Chloroform, Methanol |
| Vapor Presure | 17.8mmHg at 25°C |
| Appearance | White crystal |
| Color | White |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.454 |
| MDL | MFCD00135139 |
| Physical and Chemical Properties |
|
| Use | As an intermediate of the antihypertensive drug olmesartan |
DMDO - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R37 - Irritating to the respiratory system R36 - Irritating to the eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S36 - Wear suitable protective clothing. |
| HS Code | 29329990 |
DMDO - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| application | 4, 5-dimethyl-1, 3-dioxocyclopenten-2-one is an organic synthesis intermediate and a pharmaceutical intermediate. It is mainly used as an intermediate of the antihypertensive drug olmesartan in the laboratory research and development process and chemical production process. |
| Uses | 4, 5-dimethyl-1, 3-dioxocyclopenten-2-one is an important organic synthesis intermediate In the pharmaceutical industry, it is mainly used to synthesize new semi-synthetic antibiotics, such as semi-synthetic penicillin-ramampicillin hydrochloride (LenampicillinHydrocloride). used as an intermediate of olmesartan, an antihypertensive drug olmesartan intermediate |
| synthesis method | using hydroxybutanone and phosgene as raw materials, the optimal process conditions for synthesizing the acylation intermediate butanone chloroformate are as follows: depolymerization of hydroxybutanone for 2 hours, feeding at reaction temperature of 5 ~ 15C, molar ratio of hydroxybutanone to phosgene of 1:1.5, molar ratio of hydroxybutanone to acid binding agent of 1:1.5, the mass ratio of hydroxybutanone to solvent dichloroethane is 1:10, the reaction time is 2~3 hours, the washing condition is a single water consumption of 2mL.g-1, and the washing temperature is 0~5 ℃. Under these conditions, the acylation reaction yield reached more than 90%. |
Last Update：2024-04-10 22:29:15
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