DMH1
DMH 1
CAS: 1206711-16-1
Molecular Formula: C24H20N4O
DMH1 - Names and Identifiers
DMH1 - Physico-chemical Properties
| Molecular Formula | C24H20N4O |
| Molar Mass | 380.44 |
| Density | 1.24±0.1 g/cm3(Predicted) |
| Melting Point | 178 °C |
| Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Appearance | powder |
| Color | light yellow to orange |
| pKa | 3.34±0.46(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | DMH1 inhibit BMP signaling with IC50 of 100 nM, and selective inhibit the BMP-induced Smad1/5/8 activation. DMH1 increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. In addition, DMH1 as a BMP inhibitor, significant reductions NSCLC cell growth, migration and invasion. DMH1 inhibits BMP signaling with an IC50 of 100 nM and selectively inhibits BMP-induced Smad1/5/8 activation. DMH1 increases mouse embryonic stem cell cardiomyocyte progenitor cells and promotes myocardial differentiation. In addition, DMH1, as a BMP inhibitor, significantly reduced NSCLC cell growth, migration and invasion. |
| In vivo study | DMH1 dorsalizes the embryonic axis without disrupting the angiogenic process in zebrafish embryos. In proepicardial extracts, DMH1 results in the great inhibition of epiplasmatic sheet migration. DMH1 (5 mg/kg I. p.)attenuates Xeno raft lung tumor growth in mice bearing A549 Xeno raft. DMH1 dorsal the embryonic axis of zebrafish embryos without disrupting the angiogenic process. DMH1 causes the greatest inhibition of epithelial cell layer migration in the epicardial graft tissue. DMH1 (5 mg/kg I. p.) attenuated xenograft lung tumor growth in mice bearing A549 xenografts. |
DMH1 - Risk and Safety
| Hazard Symbols | T - Toxic |
| Risk Codes | 25 - Toxic if swallowed |
| Safety Description | 45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| WGK Germany | 3 |
DMH1 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.629 ml | 13.143 ml | 26.285 ml |
| 5 mM | 0.526 ml | 2.629 ml | 5.257 ml |
| 10 mM | 0.263 ml | 1.314 ml | 2.629 ml |
| 5 mM | 0.053 ml | 0.263 ml | 0.526 ml |
Last Update：2024-01-02 23:10:35
DMH1 - Reference Information
| biological activity | DMH1 is a selective BMP receptor inhibitor that inhibits ALK2 with an IC50 of 107.9 nM, KDR (VEGFR-2) and PDGFR had no inhibitory effect. DMH1 is a selective BMP receptor inhibitor that inhibits ALK2 with an IC50 of 107.9 nM and has no inhibitory effect on AMPK, ALK5, KDR (VEGFR-2) and PDGFR. DMH1 can inhibit autophagy. |
| in vitro study | DMH1 inhibit BMP signaling with IC50 of 100 nM, the BMP-induced Smad1/5/8 activation. DMH1 increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells. In addition, DMH1 as a BMP inhibitor, significant reductions NSCLC cell growth, migration and invasion. DMH1 inhibits BMP signaling with an IC50 of 100 nM and selectively inhibits BM P-induced Smad1/5/8 activation. DMH1 increases mouse embryonic stem cell cardiomyocyte progenitor cells and promotes myocardial differentiation. In addition, DMH1, as a BMP inhibitor, significantly reduced NSCLC cell growth, migration and invasion. |
| in vivo study | DMH1 saldorizes the embylonic axis. In proepicardial extracts, DMH1 results in the great inhibition of epiplasmatic sheet migration. DMH1 (5 mg/kg I. p.)attenuates Xeno raft lung tumor growth in mice bearing A549 Xeno raft. DMH1 dorsal the embryonic axis of zebrafish embryos without disrupting the angiogenic process. DMH1 causes the greatest inhibition of epithelial cell layer migration in the epicardial graft tissue. DMH1 (5 mg/kg I. p.) attenuated xenograft lung tumor growth in mice bearing A549 xenografts. |
| Target | TargetValue ALK2 (Cell-free assay) 107.9 nM |
| Target | Value |
| ALK2 (Cell-free assay) | 107.9 nM |
Last Update：2024-04-10 22:29:15
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Product Name: DMH 1 Visit Supplier Webpage Request for quotation
CAS: 1206711-16-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 1206711-16-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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