DMOG
DMOG
CAS: 89464-63-1
Molecular Formula: C6H9NO5
DMOG - Names and Identifiers
DMOG - Physico-chemical Properties
| Molecular Formula | C6H9NO5 |
| Molar Mass | 175.14 |
| Density | 1.246±0.06 g/cm3(Predicted) |
| Melting Point | 46-48°C |
| Boling Point | 179-182 °C(Press: 12 Torr) |
| Water Solubility | Soluble in water at 30mg/ml. |
| Storage Condition | -20℃ |
| Physical and Chemical Properties | Bioactive DMOG (Dimethyloxalylglycine) is an antagonist of α-ketoglutarate cofactor and an inhibitor of HIF prolylhydroxylase. It stabilizes and accumulates HIF-1α protein in the nucleus and is an agonist of HIF-1α. DMOG can increase autophagy. |
DMOG - Risk and Safety
| Risk Codes | 22 - Harmful if swallowed |
DMOG - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 5.71 ml | 28.549 ml | 57.097 ml |
| 5 mM | 1.142 ml | 5.71 ml | 11.419 ml |
| 10 mM | 0.571 ml | 2.855 ml | 5.71 ml |
| 5 mM | 0.114 ml | 0.571 ml | 1.142 ml |
Last Update：2024-01-02 23:10:35
DMOG - Nature
| storage conditions | -20°C |
| solubility | H2O: >30mg/mL |
| acidity coefficient (pKa) | 10.55±0.46(Predicted) |
| morphology | Solid |
| color | white to off-white |
| water solubility | Soluble in water at 30mg/ml. |
Last Update：2024-04-10 22:29:15
DMOG - Uses and synthesis methods
in vitro study
DMOG has only very low activity in the microsomal system, but it can strongly inhibit the synthesis of hydroxyproline in intact cells. In HPASMC, DMOG reduces FGF-2-induced tissue and cyclin A expression by inhibiting prolyl hydroxylase.
in vivo studies
In mouse ischemic skeletal muscle, DMOG inhibits endogenous HIF inactivation and induces angiogenesis. Hypoxia-inducible factor 1a up-regulated by DMOG can enhance the cardioprotective effect of ischemic postconditioning in rats with hyperlipidemia.
Last Update：2024-04-10 22:29:15
DMOG - Security information
| WGK Germany | 3 |
| HazardClass | IRRITANT |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: Dimethyloxaloylglycine Visit Supplier Webpage Request for quotationCAS: 89464-63-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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