DO-IN-2
IDO-IN-2
CAS: 1668565-74-9
Molecular Formula: C29H35N7O
DO-IN-2 - Names and Identifiers
| Name | IDO-IN-2 |
| Synonyms | DO-IN-2 IDO-IN-2 PCC0208009 IDO inhibitor 2 Urea, N-[4-[bis(2-methylpropyl)amino]-2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-3-yl]-N'-(4-methylphenyl)- |
| CAS | 1668565-74-9 |
DO-IN-2 - Physico-chemical Properties
| Molecular Formula | C29H35N7O |
| Molar Mass | 497.63 |
| Density | 1.206±0.06 g/cm3(Predicted) |
| Solubility | DMSO: ≥ 31 mg/mL |
| pKa | 4.17±0.10(Predicted) |
| Storage Condition | -20℃ |
| Use | IDO-IN-2 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with IC50 of 0.068 uM. |
| Target | IDO |
DO-IN-2 - Reference
| Reference Show more | 1. Yu Wang, et al. PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala. Biochem Pharmacol. 2020 Jul;177:113926.2. David K Williams, et al. Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. Bioorg Med Chem Lett. 2018 Feb 15;28(4):732-736.3. Shanyue Sun, et al. PCC0208009 enhances the anti-tumor effects of temozolomide through direct inhibition and transcriptional regulation of indoleamine 2,3-dioxygenase in glioma models. Int J Immunopathol Pharmacol. Jan-Dec 2018;32:2058738418787991. |
DO-IN-2 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.01 ml | 10.048 ml | 20.095 ml |
| 5 mM | 0.402 ml | 2.01 ml | 4.019 ml |
| 10 mM | 0.201 ml | 1.005 ml | 2.01 ml |
| 5 mM | 0.04 ml | 0.201 ml | 0.402 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Spot supply
Product Name: IDO-IN-2 Visit Supplier Webpage Request for quotationCAS: 1668565-74-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: IDO-IN-2 Visit Supplier Webpage Request for quotationCAS: 1668565-74-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History