DODAP
1,2-Dioleoyloxy-3-(dimethylamino)propane
CAS: 127512-29-2
Molecular Formula: C41H77NO4
DODAP - Names and Identifiers
| Name | 1,2-Dioleoyloxy-3-(dimethylamino)propane |
| Synonyms | DODAP DODAP 1,2-DIOLEOYL-3-DIMETHYLAMMONIUM-PROPANE 1,2-DIOLEOYLOXY-3-(DIMETHYLAMINO)PROPANE 1,2-Dioleoyloxy-3-(dimethylamino)propane 1,2-Di(oleoyloxy)-3-(dimethylamino)propane (Z)-3-(Dimethylamino)propane-1,2-diyl dioleate 1,2-dioleoyl-3-dimethylammonium-propane (DODAP) 9-Octadecenoic acid (Z)-, 1-[(dimethylamino)methyl]-1,2-ethanediyl ester 9-Octadecenoic acid(9Z)-1,1'-[1-[(dimethylamino)methyl]-1,2-ethanediyl] ester 9-Octadecenoicacid (9Z)-, 1-[(dimethylamino)methyl]-1,2-ethanediyl ester (9CI) |
| CAS | 127512-29-2 |
| InChI | 1S/C41H77NO4/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-40(43)45-38-39(37-42(3)4)46-41(44)36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h19-22,39H,5-18,23-38H2,1-4H3/b21-19-,22-20- |
DODAP - Physico-chemical Properties
| Molecular Formula | C41H77NO4 |
| Molar Mass | 648.05 |
| Solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| Appearance | Oil |
| Color | Colourless to Light Yellow |
| Storage Condition | -20°C Freezer, Under Inert Atmosphere |
| Stability | Light Sensitive; Hydroscopic; Store at -15 to -25°C |
| Physical and Chemical Properties | -20°C Freezer, Under Inert Atmosphere |
| Use | Light Sensitive; Hydroscopic; Store at -15 to -25°C |
DODAP - Introduction
1,2-dioleoyloxy -3-(dimethylamino) propane, also known as DODAP, is a compound with the chemical formula C43H83NO5. It is a chemically organic cationic surfactant with two oleoyloxy chains and an alkyl chain containing a dimethylamino group.
DODAP can form a twin structure in solution, which makes it have a strong affinity on the biological membrane interface. Therefore, it is widely used to study the properties and functions of cell membranes. It can be used as a carrier to dissolve and deliver DNA, RNA or drugs, so it has important applications in the field of gene delivery research and drug delivery.
The preparation of DODAP generally involves the reaction of dioleic acid and 3-(dimethylamino) propanol. First, dioleic acid and 3-(dimethylamino) propanol are reacted by heating to form the corresponding ester. The ester is then converted to DODAP by a nucleophilic substitution reaction or an acid-catalyzed hydrolysis reaction of the ester.
Regarding safety information, DODAP is a chemical substance with certain toxicity. When using or handling DODAP, you should take appropriate protective measures, such as wearing protective gloves, masks and safety glasses, and ensure that you operate in a well-ventilated area. In addition, direct contact with skin, breathing or swallowing DODAP should be avoided, and waste should be disposed of properly to avoid environmental pollution. When using, it is recommended to refer to the relevant literature and safety data sheets.
DODAP can form a twin structure in solution, which makes it have a strong affinity on the biological membrane interface. Therefore, it is widely used to study the properties and functions of cell membranes. It can be used as a carrier to dissolve and deliver DNA, RNA or drugs, so it has important applications in the field of gene delivery research and drug delivery.
The preparation of DODAP generally involves the reaction of dioleic acid and 3-(dimethylamino) propanol. First, dioleic acid and 3-(dimethylamino) propanol are reacted by heating to form the corresponding ester. The ester is then converted to DODAP by a nucleophilic substitution reaction or an acid-catalyzed hydrolysis reaction of the ester.
Regarding safety information, DODAP is a chemical substance with certain toxicity. When using or handling DODAP, you should take appropriate protective measures, such as wearing protective gloves, masks and safety glasses, and ensure that you operate in a well-ventilated area. In addition, direct contact with skin, breathing or swallowing DODAP should be avoided, and waste should be disposed of properly to avoid environmental pollution. When using, it is recommended to refer to the relevant literature and safety data sheets.
Last Update：2024-04-09 21:01:54
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