DOPG

DOPG - Names and Identifiers

Name	1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)
Synonyms	DOPG L-ALPHA-PHOSPHATIDYL-DL-GLYCEROL, DIOLEOYL SODIUM SALT 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHO-RAC-GLYCEROL SODIUM SALT 1,2-dioleoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt) 1,2-DIELAIDOYL-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL)] (SODIUM SALT) 1,2-Dioleoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt(DOPG) 1,2-DI[(CIS)-9-OCTADECENOYL]-SN-GLYCEROL-3-PHOSPHO-[1-RAC-GLYCEROL] SODIUM SALT
CAS	67254-28-8
EINECS	200-663-8
InChIKey	IUVFCFQZFCOKRC-PDSLQGCUSA-M

DOPG - Physico-chemical Properties

Molecular Formula	C42H78O10PNa
Molar Mass	797.026
Flash Point	>200℃
Appearance	solution
Storage Condition	-20℃

DOPG - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	R22 - Harmful if swallowed R38 - Irritating to the skin R40 - Limited evidence of a carcinogenic effect R48/20/22 - R67 - Vapors may cause drowsiness and dizziness R36/38 - Irritating to eyes and skin. R20 - Harmful by inhalation R63 - Possible risk of harm to the unborn child
Safety Description	S36/37 - Wear suitable protective clothing and gloves. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs	UN 1888 6.1/PG 3
WGK Germany	3

DOPG - Introduction

1,-(1 '-rac-glycerol) (sodium salt) is a glycerin derivative containing two oleoyl groups and one phosphoryl group, in which the ester bond is followed by two oleoyl groups and a glycerin group. This compound exists mainly in the form of its sodium salt.

This compound has the following properties:
-Colorless to light yellow powder or oily liquid.
-insoluble in water, but soluble in organic solvents.
-Stable under neutral or acidic conditions, but will decompose under alkaline conditions.

This compound has the following uses:
-In the medical field, it is often used as a phospholipid analog, which has the effect of regulating cell membrane fluidity and cell signaling.
-It can participate in cell signal transduction as a bioactive molecule in biological membranes and as a carrier in drug delivery systems.

The preparation of this compound is generally completed by chemical synthesis, the specific steps are as follows:
1. First, two esterification reactions of oleic acid and glycerol need to be synthesized to obtain 1,2-dioleoyl-sn-glycerol.
2. Next, 1,2-dioleoyl-sn-glycerol is reacted with phosphoric acid and a halogenated nucleophile (such as phosphorus trichloride) to generate 1,2-dioleoyl-sn-glycerol -3-phosphate.
3. Finally, by reacting with alkali, the phosphate group is converted into the sodium salt form to obtain 1,-(1 '-rac-glycerol salt) (sodium salt).

For safety information, this compound is generally safe under the correct conditions of use and storage, but caution is required. Possible hazards include skin and eye irritation, and direct contact should be avoided. Wear protective gloves and goggles when in use, and make sure to operate in a well-ventilated place. Detailed safety practices and precautions should follow the safety data sheets of the relevant chemicals.

Last Update：2024-04-09 21:01:54