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aspoxicillin

CAS: 63358-49-6

Molecular Formula: C21H27N5O7S

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DOYLE - Names and Identifiers

Name aspoxicillin
Synonyms DOYE
ASPC
Doyle
63358-49-6
Aspoxicilin
ASPOXICILLIN
aspoxicillin
N4-Methyl-D-asparaginylamoxicillin
n(sup4)-methyl-d-asparagininylamoxicillin
glycinamide,n-methyl-d-asparaginyl-n-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-a
zabicyclo(3.2.0)hept-6-yl)-d-2-(4-hydroxyphenyl)-,(2s-(2-alpha,5-alpha,6-beta)
6-[D-2-(D-2-Amino-3-N-methylcarbamoylpropionamido)-2-p-hydroxyphenylacetamido]penicillanic Acid
[2S-(2a,5a,6b)]-N-Methyl-D-asparaginyl-N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-D-2-(4-hydroxyphenyl)glycinamide
Glycinamide, N-methyl-D-asparaginyl-N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-6-yl)-D-2-(4-hydroxyphenyl)-, [2S-(2a,5a,6b)]-
(2S,5R,6R)-6-({(2R)-2-(4-Hydroxyphenyl)-2-[(N-methyl-D-asparaginyl)amino]acetyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
(2S,5R,6R)-6-[(2R)-2-[(2R)-2-Amino-3-(methylcarbamoyl)propionamido]-2-(p-hydroxyphenyl)acetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid
(2s,5r,6r)-6-[(2r)-2-[(2r)-2-amino-3-(n-methylcarbamoyl)-propionamido]-2-(p-hydroxyphenyl)acetamido]-3,3-dimehtyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-2-[[(2R)-2-amino-4-(methylamino)-1,4-dioxobutyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-, (2S,5R,6R)-
CAS 63358-49-6
InChI InChI=1/C21H27N5O7S/c1-21(2)15(20(32)33)26-18(31)14(19(26)34-21)25-17(30)13(9-4-6-10(27)7-5-9)24-16(29)11(22)8-12(28)23-3/h4-7,11,13-15,19,27H,8,22H2,1-3H3,(H,23,28)(H,24,29)(H,25,30)(H,32,33)/t11-,13-,14-,15+,19-/m1/s1

DOYLE - Physico-chemical Properties

Molecular FormulaC21H27N5O7S
Molar Mass493.53
Density1.51±0.1 g/cm3(Predicted)
Melting Point195-198° (dec)
Boling Point985.1±65.0 °C(Predicted)
Flash Point549.5°C
Solubility DMSO (Slightly, Sonicated), Methanol (Slightly)
Vapor Presure0mmHg at 25°C
Appearanceneat
ColorWhite to Off-White
pKa2.44±0.50(Predicted)
Storage Condition2-8°C
Refractive Index1.672
Physical and Chemical PropertiesColorless crystalline powder, melting point 195~198 C (decomposition).
Use[Function and use]] This product is a semi-synthetic penicillin broad-spectrum antibiotics, has a strong antibacterial effect, antibacterial spectrum including Staphylococcus, Streptococcus, Pneumonia cocci and other Gram-positive bacteria and Escherichia coli, gram-negative bacteria, such as influenza and anaerobic Bacteroides. It is clinically used for septicemia, endocarditis, respiratory tract infection, biliary tract infection and peritonitis caused by sensitive bacteria.
In vitro study Aspoxicillin is a semisynthetic penicillin derivative Aspoxicillin induces postantibiotic effects (PAEs) against Staphylococcus aureus Smith of 1.7 h in vitro.
In vivo study Aspoxicillin induces PAEs against Staphylococcus aureus Smith of 5.2 h in vivo in a thigh infection model in neutropenic mice.

DOYLE - Risk and Safety

Hazard SymbolsXi - Irritant
Irritant
Risk Codes36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany3
RTECSMB7548000
DOYLE
Supplier List
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Aspoxicillin Visit Supplier Webpage Request for quotation
CAS: 63358-49-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Aspoxicillin Visit Supplier Webpage Request for quotation
CAS: 63358-49-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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