Darunavir
Darunavir
CAS: 206361-99-1
Molecular Formula: C27H37N3O7S
Darunavir - Names and Identifiers
| Name | Darunavir |
| Synonyms | D03656 TMC-114 Darunavir UIC-94017 (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate [(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-β]-furan-3-yl Ester [(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenyl-methyl)propyl]carabamic Acid (3R,3aS,6aR)-Hexahydrofuro[2,3-b]-furan-3-yl Ester |
| CAS | 206361-99-1 |
| EINECS | 606-590-1 |
| InChI | InChI=1/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1 |
Darunavir - Physico-chemical Properties
| Molecular Formula | C27H37N3O7S |
| Molar Mass | 547.66 |
| Density | 1.34±0.1 g/cm3(Predicted) |
| Melting Point | 74-760C |
| Solubility | Soluble in chloroform, and methanol. |
| Appearance | White amorphous solid |
| Color | white to beige |
| pKa | 11.43±0.46(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Refractive Index | 1.62 |
| Use | HIV protease inhibitors. An antiviral agent |
| In vitro study | Darunavir (TMC114, 1a) has a stability comparable to other protease inhibitors. Darunavir (TMC114, UIC-94017) blocks the infectivity and replication of each of HIV-1 NL4-3 variants exposed to and selected for resistance to Ro 31-8959, MK-639, AG1341, or ABT 538 at concentrations up to 5 μM (IC 50 s, 0.003 to 0.029 μM), although it was less active against HIV-1 NL4-3 variants selected for resistance to VX-478 (IC 50 , 0.22 μM). |
Darunavir - Risk and Safety
| WGK Germany | 3 |
Darunavir - Introduction
HIV-1 antiviral structurally similar to amprenavir. Second generation HIV-1-protease inhibitor.
Last Update：2022-10-16 17:14:51
Supplier List
Spot supply
Product Name: Darunavir Visit Supplier Webpage Request for quotationCAS: 206361-99-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Darunavir Visit Supplier Webpage Request for quotationCAS: 206361-99-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Darunavir Visit Supplier Webpage Request for quotationCAS: 206361-99-1
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: Darunavir Visit Supplier Webpage Request for quotationCAS: 206361-99-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History