Dendrobine
Dendrobine
CAS: 2115-91-5
Molecular Formula: C16H25NO2
Dendrobine - Names and Identifiers
Dendrobine - Physico-chemical Properties
| Molecular Formula | C16H25NO2 |
| Molar Mass | 263.379 |
| Density | 1.101 |
| Melting Point | 135-136℃ |
| Boling Point | 375℃ |
| Specific Rotation(α) | -48.4 (c, 1.89 in MeOH) |
| Flash Point | 133℃ |
| Solubility | Easily soluble in ether and chloroform, hardly soluble in ethanol and water. |
| Appearance | White powder |
| pKa | 9.49±0.60(Predicted) |
| Storage Condition | 2-8℃ |
| Physical and Chemical Properties | Chemical properties are easily soluble in ether and chloroform, but hardly soluble in ethanol and water. Effective ingredients derived from Dendrobium and bark. |
| Use | Uses for content determination/identification/pharmacological experiments, etc. Pharmacological effects: Dendrobium has analgesic and antipyretic effects, can reduce heart rate, blood pressure, slow down breathing, has a strong effect and can relieve barbiturism. |
Dendrobine - Risk and Safety
| HS Code | 29399990 |
Dendrobine - Reference
| Reference Show more | 1. Meng Yingxia Ma Chaoyang Wang Hongxin et al. Effects of different drying techniques on quality of Dendrobium nobile leaves [J]. Chinese Journal of Experimental prescriptions 2017(15):34-38. 2. Li Zhenjian, Zhou Wenya, Han Bin, etc. Study on alkaloids of Dendrobium rose based on UPLC-Q-TOF-MS technology [J]. Natural product research and development, 2020, v.32(03):71 127-133. 3. Lu chaogeng, Guo Lanping, Li Jiaxing, et al. Accumulation changes of phenolic, organic acid and flavonoid components in dendrobium officinale at different growth stages in Zhejiang [J]. Chinese Journal of Traditional Chinese Medicine, 2019, 034(005):1989-1992. 4. Chen Min, Chen Yuchao, Huang Wenlu, et al. Effect of fresh juice processing methods on the dissolution of total alkaloids from Dendrobium [J]. Food Research and Development, 2019(12). 5. Huang Zhen-yong, Zhang e-zhen, Tamming et al. Effects of lactic acid bacteria fermentation on active substance content and antioxidant capacity of dendrobium officinale [J]. Chinese Journal of Tropical Crops, 2020 v.41(03):161-167. 6. Liu, Huifan, et al. "Dendrobine Suppresses Lipopolysaccharide-induced Gut Inflammation in a Co-culture of Intestinal Epithelial Caco-2 Cells and RAW264. 7 Macrophages." eFood 2.2 (2021): 92-99.https://doi.org/10.2991/efood.k.210409.001 7. Yang, Ke, et al. "Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway." Cytokine 130 (2020): 155058.https://doi.org/10.1016/j.cyto.2020.155058 8. Yang Ke, et al. "Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway." Cytokine 130 (2020): 155058.https://doi.org/10.1016/j.cyto.2020.155058 9. [IF=2.952] Ke Yang et al."Dendrobium officinale polysaccharides protected against ethanol-induced acute liver injury in vivo and in vitro via the TLR4/NF-κB signaling pathway."Cytokine. 2020 Jun;130:155058 10. [IF=4.36] Danfei Lou et al."Dendrobine modulates autophagy to alleviate ox-LDL-induced oxidative stress and senescence in HUVECs."DRUG DEVELOPMENT RESEARCH. 2022 Apr 13 |
Dendrobine - Uses and synthesis methods
Dendrobium
Dendrobium is also known as Linlan, Duran, Millennium Bamboo and Yellow Grass. Sweet in taste, slightly cold in nature, return to the stomach, lung, and kidney meridian, nourishing body fluid and nourishing the stomach, nourishing yin and clearing heat, moisturizing the lungs and benefiting the kidneys. It is the stem of the orchid plant Dendrobium, Dendrobium whip, Dendrobium yellow grass, Dendrobium officinale or Dendrobium nobile. It is mainly produced in Sichuan, Guizhou, Yunnan and other places. It can be harvested throughout the year to remove impurities, slightly scalded or soft with boiling water, and then baked while rubbing, until the leaf sheath is rubbed and dried. After cutting off part of the fibrous roots of Dendrobium candidum, stir-fry and twist into a spiral or spring shape, and dry it, commonly known as "Dendrobium earrings".
Pharmacological action
Dendrobium contains more than ten kinds of alkaloids such as dendrobium, dendrobium amine, dendrobium secondary alkali, dendrobium base, dendrobium base, 6-hydroxydendrobium base, mucus, starch, etc.
Dendrobium has analgesic and antipyretic effects, can reduce heart rate, blood pressure, slow down breathing, has a strong effect and can relieve barbiturism. Pharmacological tests have shown that oral administration of Dendrobium decoction can promote the secretion of gastric juice and help digestion, make intestinal peristalsis hyperactive and defecate, but if the dose is too large, it can cause intestinal muscle paralysis; Dendrobium has a certain antipyretic and analgesic effect, Similar to non-naxetine, but the effect is weak; Dendrobium polysaccharide can restore the immune function of mice; it has anti-aging and delayed cataract effects. The two phenanthrene compounds extracted from Dendrobium nobile have anti-human lung cancer, ovarian adenocarcinoma and anterior myeloid leukemia; Dendrobium nobile can significantly increase the level of SOD (superoxide dismutase) and reduce LPO (lipid peroxide) And play a role in delaying aging; an ester component contained in Dendrobium also has the effects of promoting blood circulation and removing blood stasis, treating thromboangiitis obliterans, cerebral thrombosis, and arteriosclerotic occlusion.
application of traditional Chinese medicine
1. It is used for heat, sickness and injury, dry mouth, irritation and thirst, and deficiency and heat. It is often used in the same way as Trichosanthis, Rehmannia glutinosa, Forsythia suspensa, etc. If both qi and yin are injured, thirst and fever, shortness of breath and fatigue, each with Astragalus, Ophiopogon japonicus, Shengdi, etc., the prescription is like Dendrobium Decoction.
2. It is used for gastric noise, dull pain or burning pain, retching and less coating caused by insufficient stomach yin and deficiency heat. It is often used in the same way as bamboo shavings, reed root, loquat leaves, etc.; if the heat is obvious, the heat is blocked and the vomit is caused, it can also be used in the same way as the skin and the agastache.
3. It is used for deficiency of liver and kidney yin, loss of eyesight and loss of nourishing. It is often used in the same way as wolfberry, chrysanthemum, cassia seed, etc., such as Dendrobium Xiguang Pills; if the liver and kidney are deficient and wet and cause night blindness, it can be used with atractylodes and epimedium, such as Dendrobium powder.
4. It is used for deficiency of kidney yin, sore waist and knees, and soft muscles and bones. It is often used with Achyranthes bidentata, Eucommia ulmoides, Dipsacus, etc.; if the kidney is weak and the fire is high, the bones are steamed and hot, it can be used with Phellodendron, Anemarrhena, Radix Rehmanniae, and Huhuanglian.
biological activity
Dendrobine is a plant alkali isolated from Dendrobium, which is used for quality control and identification of Dendrobium Dendrobium.
Last Update：2024-04-09 01:59:51
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