Molecular Formula | C19H20O6 |
Molar Mass | 344.36 |
Density | 1.26±0.1 g/cm3(Predicted) |
Melting Point | 198-200 °C |
Boling Point | 584.3±50.0 °C(Predicted) |
Specific Rotation(α) | -54.6 |
Storage Condition | 2-8℃ |
Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Elephantopus scaber. |
In vitro study | Deoxyelephantopin inhibits the cell growth of HCT 116 (colorectal), K562 (chronic myeloid leukemia), KB (oral), and T47D (breast) cancer cell lines with IC 50 s of 7.46, 4.02, 3.35, 1.86 μg/mL, respectively. Deoxyelephantopin increases the expression of p53, p-JNK, and p-p38 and decreases the expression of p-STAT3 and p-mTOR in cancer cells. Deoxyelephantopin downregulates MMP-2 and MMP-9, uPA, and uPAR mRNA levels in cancer cells. |