Deoxyguanosine
2'-deoxyguanosine
CAS: 961-07-9;19916-78-0
Molecular Formula: C10H13N5O4
Deoxyguanosine - Names and Identifiers
| Name | 2'-deoxyguanosine |
| Synonyms | DG Deoxyguanosine 2'-deoxyguanosine DEOXYGUANOSINE-2' A-2'-DEOXYGUANOSINE A-2'-deoxyguanosine α-2'-Deoxyguanosine 2'-DEOXY-D-GUANOSINE GUANINE DESOXYRIBOSIDE 2'-deoxyguanosine hemihydrate 2'-Deoxyguanosine monohydrate 2[-Deoxyguanosine hemihydrate 9-(2'-DEOXY-BETA-D-RIBOFURANOSYL)GUANINE 2-amino-9-(2-deoxypentofuranosyl)-3,9-dihydro-6H-purin-6-one 6H-Purin-6-one, 2-amino-9-(2-deoxy-α-D-erythro-pentofuranosyl)-1,9-dihydro- 2-amino-9-(2-deoxy-alpha-L-erythro-pentofuranosyl)-3,9-dihydro-6H-purin-6-one 2-AMino-9-((2R,4S,5S)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one |
| CAS | 961-07-9 19916-78-0 |
| EINECS | 213-505-8 |
| InChI | InChI=1/C10H13N5O4/c11-10-13-8-7(9(18)14-10)12-3-15(8)6-1-4(17)5(2-16)19-6/h3-6,16-17H,1-2H2,(H3,11,13,14,18)/t4-,5+,6-/m1/s1 |
Deoxyguanosine - Physico-chemical Properties
| Molecular Formula | C10H13N5O4 |
| Molar Mass | 267.25 |
| Density | 2.08±0.1 g/cm3(Predicted) |
| Melting Point | 300℃ |
| Boling Point | 725.5°C at 760 mmHg |
| Specific Rotation(α) | -42 ° (C=0·2, 1mol/L NaOH) |
| Flash Point | 392.6°C |
| Solubility | Soluble in water. Easily hydrolyzed by dilute inorganic acids. |
| Vapor Presure | 4.32E-22mmHg at 25°C |
| Appearance | White crystalline powder |
| pKa | 9?+-.0.20(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.907 |
| MDL | MFCD00080300 |
| Physical and Chemical Properties |
|
Deoxyguanosine - Risk and Safety
| Safety Description | S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-23 |
Deoxyguanosine - Reference
| Reference Show more | 1. Xiao Hui-min, He Yue, ramena, etc. HPLC characteristic chromatogram and quantitative analysis of 10 components of earthworm capsule [J]. Northwest Pharmaceutical Journal, 2018, 033(005):569-574. 2. Zhang Huang-Qin, Liu Pei, Qian Da-wei, et al. Study on modern drying and processing methods of Trichosanthes pericarpium based on multi-functional components [J]. Chinese herbal medicine, 2020, v.51;No.663(04):127-141. 3. Liu Zhengbo, Zhang yayuwang, Qiuxia et al. Effects of different potassium levels on the contents of nucleosides in panax ginseng [J]. Journal of Jilin Agricultural University, 2019, 41(4):432-437. 4. He Yue, Xiao Hui-min, Kang Xiao-Gang, et al. Study on radiosensitization of earthworm capsule and its principal components on S_(180) transplanted tumor in mice [J]. Northwest Pharmaceutical Journal, 2019. 5. Li Dan, Liu Pei, Zhang Huang Qin, Li Wei Wen, Yan Hui, Shang er Xin, Wei Dan Dan, Dong Ling, Duan Jin Yu. Study on multi-type resource chemical composition analysis and quality evaluation of pericarpium trichosanthis from different origins and different strains [J]. Journal of Nanjing University of Traditional Chinese Medicine, 2020,36(05):607-614. 6. [IF = 5.923] Cuihua Chen et al."Variations in Physiology and Multiple Bioactive Constituents under Salt Stress Provide Insight into the Quality Evaluation of Apocyni Veneti Folium."Int J Mol Sci. 2018 Oct;19(10):3042 7. [IF=4.411] Cuihua Chen et al."Quality Evaluation of Apocyni Veneti Folium from Different Habitats and Commercial Herbs Based on Simultaneous Determination of Multiple Bioactive Constituents Combined with Multivariate Statistical Analysis."Molecules. 2018 Mar;23(3):5 8. [IF=4.616] Xiaoyong Zhao et al."Lignin as a MALDI matrix for small molecules:A proof of concept."Analyst. 2021 Oct;: 9. [IF=4.411] Mengxia Tan et al."Quality Evaluation of Ophiopogonis Radix from Two Different Producing Areas."Molecules. 2019 Jan;24(18):3220 |
Deoxyguanosine - Introduction
2 '-deoxyguanosine(2'-deoxyguanosine) is a nucleoside formed from deoxyguanine and the guanosine base guanine. The following is a detailed description of the nature, use, formulation and safety information of 2 '-deoxyguanosine:
1. nature:
-Appearance: Colorless or white crystalline powder
-Solubility: Soluble in water and acidic solution, insoluble in organic solvents such as alcohol and ether
-Chemical structure: 2 '-deoxyguanosine lacks an oxygen atom at the 2' position. Compared with guanosine, the oxygen atom on the guanine base is slightly replaced.
2. use:
-Biochemical research: 2 '-deoxyguanosine is one of the basic components of the construction of DNA molecules, which can be used for DNA synthesis and modification.
-Drug development: 2 '-deoxyguanosine can be used to synthesize antiviral drugs, such as antiretroviral drugs.
-Molecular diagnosis: 2 '-deoxyguanosine can be used as a reference standard for nucleoside diphosphate (NTP), used for detection of enzyme activity and nucleic acid sequence analysis.
3. preparation method:
- 2 '-deoxyguanosine can be obtained by reacting guanosine with dibutyl phthalate (DBA) and dimethylaminobutanol (DMEDA) and other reagents, followed by acid hydrolysis.
4. Safety Information:
- 2 '-deoxyguanosine is relatively safe under normal conditions, but when used as a laboratory reagent, it is still necessary to use personal protective equipment, such as laboratory gloves and goggles, to avoid contact with skin and eyes.
-If ingestion or contact with 2 '-deoxyguanosine, seek medical help immediately and bring the product container or label.
1. nature:
-Appearance: Colorless or white crystalline powder
-Solubility: Soluble in water and acidic solution, insoluble in organic solvents such as alcohol and ether
-Chemical structure: 2 '-deoxyguanosine lacks an oxygen atom at the 2' position. Compared with guanosine, the oxygen atom on the guanine base is slightly replaced.
2. use:
-Biochemical research: 2 '-deoxyguanosine is one of the basic components of the construction of DNA molecules, which can be used for DNA synthesis and modification.
-Drug development: 2 '-deoxyguanosine can be used to synthesize antiviral drugs, such as antiretroviral drugs.
-Molecular diagnosis: 2 '-deoxyguanosine can be used as a reference standard for nucleoside diphosphate (NTP), used for detection of enzyme activity and nucleic acid sequence analysis.
3. preparation method:
- 2 '-deoxyguanosine can be obtained by reacting guanosine with dibutyl phthalate (DBA) and dimethylaminobutanol (DMEDA) and other reagents, followed by acid hydrolysis.
4. Safety Information:
- 2 '-deoxyguanosine is relatively safe under normal conditions, but when used as a laboratory reagent, it is still necessary to use personal protective equipment, such as laboratory gloves and goggles, to avoid contact with skin and eyes.
-If ingestion or contact with 2 '-deoxyguanosine, seek medical help immediately and bring the product container or label.
Last Update：2024-04-09 15:18:01
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View History
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2,3,3-trifluorocyclobutan-1-ol
Metastannic acid
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50638-46-5
Nofloxacin Hydrochloride
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