Dexibuprofen
Dexibuprofen
CAS: 51146-56-6
Molecular Formula: C13H18O2
Dexibuprofen - Names and Identifiers
| Name | Dexibuprofen |
| Synonyms | DEXIBUPROFEN Dexibuprofen (S)-IBUPROFEN (S)-(+)-Ibuprofen (S)-(+)-IBUPROFEN (S)-(+)-2-(4-ISOBUTYLPHENYL)PROPIONIC ACID (2S)-2-[4-(2-Methylpropyl)phenyl]propionic acid (2s)-2-[4-(2-methylpropyl)phenyl]propionic acid (2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid (S)-(+)-4-ISOBUTYL-ALPHA-METHYLPHENYLACETIC ACID |
| CAS | 51146-56-6 |
| EINECS | 610-620-9 |
| InChI | InChI=1/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1 |
| InChIKey | HEFNNWSXXWATRW-JTQLQIEISA-N |
Dexibuprofen - Physico-chemical Properties
| Molecular Formula | C13H18O2 |
| Molar Mass | 206.28 |
| Density | 1.0364 (rough estimate) |
| Melting Point | 49-53°C(lit.) |
| Boling Point | 285.14°C (rough estimate) |
| Specific Rotation(α) | 57 º (c=2, EtOH) |
| Flash Point | >230°F |
| Water Solubility | insoluble |
| Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.5mg/mL |
| Vapor Presure | 0.000139mmHg at 25°C |
| Appearance | solid |
| Color | white |
| BRN | 3590022 |
| pKa | 4.41±0.10(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Refractive Index | 59 ° (C=2, EtOH) |
| MDL | MFCD00069289 |
Dexibuprofen - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R63 - Possible risk of harm to the unborn child R22 - Harmful if swallowed |
| Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37 - Wear suitable protective clothing and gloves. |
| WGK Germany | 3 |
| HS Code | 29163990 |
Dexibuprofen - Standard
Authoritative Data Verified Data
This product is (2S)-2-[4-(2-methylpropyl) phenyl] propionic acid. Calculated as dried product, the content of C13H1802 shall not be less than 98.5%.
Last Update：2024-01-02 23:10:35
Dexibuprofen - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Slightly specific odor.
- This product is soluble in ethanol or ether, dissolved in sodium hydroxide solution; Almost insoluble in water.
melting point
The melting point of this product (General rule 0612) is 48~53°C, and the melting distance is not more than 2°C.
specific rotation
take this product, precision weighing, plus anhydrous ethanol dissolution and quantitative dilution of about 10 mg per lml solution. Measured according to law (General rule 0621), the specific rotation is 56 ° to 60 °.
absorption coefficient
take this product, precision weighing, plus phosphate buffer solution (pH7.2) dissolved and quantitatively diluted to make a solution containing about 11ug per lml, the absorbance was measured at a wavelength of 222mn by ultraviolet-visible spectrophotometry (General rule 0401), and the absorption coefficient was 425 to 470.
Last Update：2022-01-01 11:36:14
Dexibuprofen - Differential diagnosis
Authoritative Data Verified Data
- in the chromatogram recorded under the item of related substances, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution with the same concentration.
- take this product, add 0.4% sodium hydroxide solution to dissolve and dilute to make a solution containing about 0401 mg per 1 ml, and measure it by UV-Vis spectrophotometry (general rule), there is maximum absorption at 265nm and 273nm wavelengths, minimum absorption at 245nm and 271nm wavelengths, and a shoulder at 259nm wavelengths.
- The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).
Last Update：2022-01-01 11:36:14
Dexibuprofen - Exam
Authoritative Data Verified Data
chloride
take this product l.Og, precision add water 50ml, shake for 5 minutes, filter, take the filtrate 25ml, check according to law (General rule 0801), compared with the control solution made of standard sodium chloride solution 5.0ml, not more concentrated (0.010%).
levoprofen
take an appropriate amount of this product, precisely weigh it, add the mobile phase to dissolve and dilute it to prepare a solution containing about 2mg per 1 ml, as a test solution; Take an appropriate amount of levoprofen control, precision weighing, plus mobile phase dissolution and quantitative dilution to prepare a solution containing 0.02mg per 1 ml, as a reference solution (1). According to the high performance liquid chromatography method (General 0512), using 0, 0-di-(4-tert-butylbenzoyl)-N,N '-Diallyl-L-tartaric acid diamine chiral bonded phase (abbreviated as CHI-TBB) as filler (Kromasil,4.6mm x mm, Bfxm or equivalent column); the mobile phase was hexane-tert-butyl methyl ether-acetic acid (850:150:1) at a flow rate of 2.0ml per minute. The detection wavelength was 220nm. An appropriate amount of ibuprofen was additionally taken, dissolved and diluted with mobile phase to make a solution containing 0.2mg per 1 ml, which was used as the applicable solution for the system. 20u1 was injected into human liquid chromatograph, and the chromatogram was recorded, the number of theoretical plates shall not be less than 2000 according to the peak of right ibuprofen, and the separation degree between the peak of right ibuprofen and the peak of left ibuprofen shall be greater than 3.0. 20 u1 of the test solution and the reference solution (1) were respectively injected into the liquid chromatograph, and the chromatograms were recorded. If there is a peak of levoprofen in the chromatogram of the test solution, the peak area shall be calculated according to the external standard method, and the peak area shall not exceed 1.0%.
Related substances
Take 20mg of this product, accurately weigh it, put it in a 10ml measuring flask, add 2ml of acetonitrile to dissolve it, dilute it to the scale with mobile phase, shake it well, and use it as a test solution; an appropriate amount was taken in a precise amount and quantitatively diluted with the mobile phase to prepare a solution containing 20ug per 1 ml as a control solution. Accurately weigh 20mg of the reference product of dexibuprofen, put it in a 10ml measuring flask, and add 2ml of acetonitrile to dissolve; Accurately weigh the reference product of a-methyl-4-butylphenylacetic acid (impurity I), acetonitrile was added to dissolve and prepare a solution containing 0.06mg per 1 ml, and 1 ml was accurately weighed, placed in the above measuring flask, diluted to the mark with mobile phase, and shaken to obtain a reference solution (2). Silica gel bonded with eighteen alkyl silanes was used as filler, and acetonitrile-phosphoric acid solution (pH value of aqueous phase was adjusted to 0512 with phosphoric acid)(45:55) was used as determined by high performance liquid chromatography (general 2.5). Mobile phase; The detection wavelength was 214nm. Take the control solution 20u1 and inject it into human liquid chromatograph, record the chromatogram, and the number of theoretical plates shall not be less than 4000 according to the peak of dexibuprofen; Take the reference solution (2)20ul and inject it into human liquid chromatograph, record the chromatogram, the resolution of the peak of dexibuprofen from the peak of impurity I should meet the requirements. The sample solution, the control solution and the reference solution (2) were 20 u1, respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of the main component peak. In the chromatogram of the test solution, if there is a chromatographic peak that is consistent with the retention time of impurity I peak in the chromatogram of the reference solution (2), the peak area shall be calculated according to the external standard method, and shall not exceed 0.3%, other single impurity peak area shall not be greater than 0.3 times (0.3%) of the main peak area of the control solution, and the sum of other impurity peak areas shall not be greater than 0.7 times (0.7%) of the main peak area of the control solution. The chromatogram of the test solution is 0.05 times smaller than the main peak area of the control solution.
residual solvent
take about 1.0g of this product, precision weighing, add 10ml of sodium carbonate solution, slightly heat dissolution, quantitative dilution to make each lml containing 0.1g of the solution was used as a test solution; An appropriate amount of toluene was accurately weighed and quantitatively diluted with sodium carbonate test solution to prepare a solution containing 89ug per 1 ml as a reference solution. 5ml of each of the test solution and the reference solution were respectively accurately measured and placed in the headspace bottle and sealed. According to the determination method of residual solvent (General Principle 0861 first method), the capillary column with 6% cyanopropylphenyl-94% dimethyl polysiloxane (or similar polarity) as the stationary liquid is the column; The column temperature is 110°C, the detector temperature was 200°C; The inlet temperature was 200°C; The headspace bottle equilibrium temperature was 80°C and the equilibrium time was 15 minutes. The test solution and the reference solution were injected into the headspace respectively, and the chromatogram was recorded, and the peak area was calculated according to the external standard method. The residual amount of toluene should be in accordance with the regulations.
loss on drying
take this product, put the phosphorus pentoxide dryer under reduced pressure to dry to constant weight, the weight loss should not exceed 0.5% (General rule 0831).
ignition residue
not over 0841 (general rule).
Heavy metals
take this product l. After adding 22ml of ethanol, add 2ml of acetate buffer (pH3.5) and an appropriate amount of water to make 25ml, and check according to law (General rule 0821, Method 1), the content of heavy metals shall not exceed 20 parts per million.
Last Update：2022-01-01 11:36:15
Dexibuprofen - Content determination
Authoritative Data Verified Data
take this product about 0.35g, precision weighing, add neutral ethanol (phenolphthalein indicator solution neutral) 50ml dissolved, add phenolphthalein indicator solution 3 drops, with sodium hydroxide titration solution (0.lmol/L) titration. Each 1 ml of sodium hydroxide titration solution (0.1 mol/L) corresponds to 20.63mg of C13H1802.
Last Update：2022-01-01 11:36:16
Dexibuprofen - Category
Authoritative Data Verified Data
antipyretic analgesic, non-steroidal anti-inflammatory drugs.
Last Update：2022-01-01 11:36:16
Dexibuprofen - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:36:16
Dexibuprofen - Dexibuprofen capsules
Authoritative Data Verified Data
This product contains dexibuprofen (C13H1802) should be the label amount of 95.0% ~ 105.0%.
trait
The content of this product is white or white particles.
identification
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- take the contents of this product, grind it finely, weigh the fine powder, dissolve and dilute it with 0.4% sodium hydroxide solution to make a solution containing about mg of dexibuprofen per 1 ml, filter it, and take the filtrate, according to UV-visible spectrophotometry (General rule 0401), there is maximum absorption at the wavelength of 265nm and 273nm, and minimum absorption at the wavelength of 245nm and 271nm, there is a shoulder at a wavelength of 259nm.
- take the contents of this product, grind it finely, weigh an appropriate amount of fine powder (about 250mg equivalent to dexibuprofen), weigh it accurately, put it in a 25ml measuring flask, add an appropriate amount of anhydrous ethanol, shake it to dissolve dexibuprofen, and dilute to the scale, shake, filter, take the filtrate, according to the law (General 0621) optical rotation should be +0.53 ° to +0.65 °.
- take 5 capsules of this product, grind the content, add acetone 20ml to dissolve dexibuprofen, filter, take the filtrate to volatilize dry, and measure after vacuum drying. The infrared absorption spectrum of this product should be consistent with that of the reference product (General rule 0402).
examination
- dissolution the dissolution of this product was determined according to the dissolution and release determination method (General rule 0931 method 1), and the dissolution medium was 100 phosphate buffer (pH7.2), and the rotation speed was rpm, operate according to law, after 30 minutes, take 5ml of the solution, filter, take the filtrate as the test solution; Take the other right ibuprofen control, precision weighing, an appropriate amount of methanol was added to dissolve and quantitatively diluted with the dissolution medium to prepare a solution containing about 0.2mg per 1 ml as a reference solution. According to the chromatographic conditions under the content determination item, 20 u1 of each of the test solution and the reference solution are accurately measured, and the dissolution amount of each particle is calculated by the peak area according to the external standard method. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others should comply with the relevant provisions under the capsule (General 0103).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test with eighteen alkyl silane bonded silica gel as filler; Sodium acetate buffer (sodium acetate 6.13g, add water 750ml to dissolve, adjust the pH value to 3.5 with glacial acetic acid)-Acetonitrile (40:60) as mobile phase; The detection wavelength was 263nm. The number of theoretical plates is not less than 2500 calculated by dexibuprofen.
- the content under the item of loading difference was measured, ground finely, mixed evenly, and accurately weighed to take an appropriate amount (about 50mg equivalent to dexibuprofen), put it in a 100ml measuring flask, and add an appropriate amount of methanol, shake to dissolve dexibuprofen, dilute to the scale with methanol, shake well, filter, take the filtrate as a test solution, take 20ul with precision, inject human liquid chromatograph, record chromatogram; in addition, the right amount of the reference substance of dexibuprofen was accurately weighed, dissolved and quantitatively diluted with fermentation broth to prepare a solution containing 0.5mg of dexibuprofen per 1 ml, and the same method was used for determination. According to the external standard method to calculate the peak area, that is.
category
Same as dexibuprofen.
specification
0.15g
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:36:17
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Spot supply
Product Name: (S)-(+)-4-Isobutyl-Alpha-Methylphenylacetic Acid Visit Supplier Webpage Request for quotationCAS: 51146-56-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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